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TranscriptomicsEffects of mutation in a soluble guanylyl cyclase gene
Genomic and behavioral investigations were performed to determine the effects of a mutation in a Drosophila soluble guanylyl cyclase gene. A mutant DGCalpha1[3] third chromosome was crossed into a natural rover (for[R]) or natural sitter (for[s]) genetic background. (See Osborne et al. 1997; PMID: ...
ORGANISM(S): Drosophila melanogaster 
2010-06-10 | E-GEOD-2136 | biostudies-arrayexpress
ProteomicsSoluble guanylyl cyclase mediates noncanonical nitric oxide signaling by nitrosothiol transfer under oxidative stress
Soluble guanylyl cyclase (GC1) is an α/β heterodimer producing cGMP when stimulated by nitric oxide (NO). The NO-GC1-cGMP pathway is essential to cardiovascular homeostasis but is disrupted by oxidative stress, which induces GC1 desensitization to NO by S-nitrosation (SNO) of its cysteines (C). We d...
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2022-10-15 | PXD033105 | Pride
Nitric oxide S-nitrosylation Cgmp S-nitrosation Oxidative stress Soluble guanylyl cyclase 
TranscriptomicsTranscriptome profiling of T84 colorectal carcinoma cells treated with receptor guanylyl cyclace C agonist (stable toxin)
Receptor guanylyl cyclase C (GC-C) is expressed in the intestinal epithelia and plays a key role in intestinal physiology. Activation of GC-C by its ligands has been shown to regulate proliferation and differentiation of enterocytes along the crypt-villus axis. This study aims to identify genes regu...
ORGANISM(S): Homo sapiens 
2014-02-04 | E-GEOD-45531 | biostudies-arrayexpress
GenomicsGenes regulated by soluble guanylyl cyclase in VCaP prostate cancer cells
Genes regulated by soluble guanylyl cyclase in VCaP prostate cancer cells
PRJNA472401 | ENA
TranscriptomicsTranscription profiling of human HUVEC cells exposed to 250 uM DETA-NONOate for 4 hours in the presence and absence of 10 uM of the guanylate cyclase inhibitor 1H-[1,2,4]oxadiazolo-[4,3,2]quinoxalin-1-one (ODQ)
HUVECs were exposed to 250 uM DETA-NONOate for 4 hours in the presence and absence of 10 uM of the guanylate cyclase inhibitor 1H-[1,2,4]oxadiazolo-[4,3,2]quinoxalin-1-one (ODQ). Control cells were exposed to vehicle (methanol 0.1%).
ORGANISM(S): Homo sapiens 
2005-04-01 | E-UMCU-7 | biostudies-arrayexpress
TranscriptomicsEffects of mutation in a soluble guanylyl cyclase gene
Genomic and behavioral investigations were performed to determine the effects of a mutation in a Drosophila soluble guanylyl cyclase gene. A mutant DGCalpha1[3] third chromosome was crossed into a natural rover (for[R]) or natural sitter (for[s]) genetic background. (See Osborne et al. 1997; PMID: 9...
ORGANISM(S): Drosophila melanogaster 
2005-05-01 | GSE2136 | GEO
TranscriptomicsGenes regulated by soluble guanylyl cyclase in VCaP prostate cancer cells
The aberrant activation of the ERG oncogenic pathway due to TMPRSS2-ERG gene fusions is the major driver of prostate cancer initiation and progression. We identified the alpha1 and beta1 subunits of soluble guanylyl cyclase (GUCY1A1, GUCY1B1) as major ERG-regulated genes in prostate cancer cells. So...
ORGANISM(S): Homo sapiens 
2018-05-22 | GSE114738 | GEO
TranscriptomicsIdentification of Notch targets in human endothelial cells
Human umbilical vein endothelial cells (HUVECs) were transduced with either MIY-N1IC (Notch1 intracellular domain) or MIY vector control. The cells were sorted for YFP, and RNA was extracted using Trizol (Invitrogen) and analyzed by the Affymetrix Human Genome U133 Plus 2.0 Array. Results were analy...
ORGANISM(S): Homo sapiens 
2011-06-09 | E-GEOD-29850 | biostudies-arrayexpress
UnknownThe linker region in receptor guanylyl cyclases is a key regulatory module: mutational analysis of guanylyl cyclase C.
Not available
S-EPMC2786029 | biostudies-literature
UnknownBinding of guanylyl cyclase activating protein 1 (GCAP1) to retinal guanylyl cyclase (RetGC1). The role of individual EF-hands.
Not available
S-EPMC2490776 | biostudies-literature
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