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TranscriptomicscGMP modulates responses to queen mandibular pheromone in worker honey bees
Responses to social cues, such as pheromones, can be modified by genotype, physiology, or environmental context. Honey bee queens produce a pheromone (queen mandibular pheromone; QMP) which regulates many aspects of worker bee behavior and physiology. Forager honey bees are less responsive to QMP t...
ORGANISM(S): Apis mellifera 
2011-06-15 | E-MEXP-3135 | biostudies-arrayexpress
ProteomicsNpr2-mediated cGMP signalling modulates S-palmitoylation and controls growth cone morphology of DRG neurons
A cGMP signalling cascade composed of the ligand C-type natriuretic peptide (CNP), the natriuretic peptide receptor 2 (Npr2) and the cGMP-dependent kinase Iα (cGKI) is implicated by growth cone splitting in the bifurcation of afferents from dorsal root ganglia (DRG), cranial sensory ganglia (CSG) an...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-18 | PXD010326 | Pride
Ap-ms Cgmp signalling Shotgun 
GenomicsChIP-Seq of the Sinorhizobium meliloti CRP-like protein Clr in combination with either cAMP or cGMP under different growth conditions
In bacteria, Crp-Fnr superfamily transcription factors mediate 3',5'-cyclic adenosine monophosphate (cAMP) and 3',5'-cyclic guanosine monophosphate (cGMP) signaling. The CRP-like protein Clr of the soil-dwelling and plant-symbiotic α-proteobacterium Sinorhizobium meliloti was previously shown to act...
ORGANISM(S): Sinorhizobium meliloti 
2023-03-23 | E-MTAB-11788 | biostudies-arrayexpress
TranscriptomicscGMP inducer effect on cell line Panc-1
cGMP is well-known secound messanger involved in vascular homeostasis. However little is known the effect of cGMP inducer on mRNA expression in cancer cells. We performed microarrays to revealed the transcriptional change of a human pancreatic ductal adenocarcinoma (PDCA) cell line (Panc -1) to cGM...
ORGANISM(S): Homo sapiens 
2016-09-01 | E-GEOD-66403 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human soluble guanylate cyclase-deficient U937 cells exposed to the nitric oxide (NO) donor S-nitrosoglutathione to provide insight into the cGMP-independent effects of NO
NO effects on gene expression, independent of cGMP, were examined globally. Differentiated human U937 cells that lack soluble guanylate cyclase were exposed to Snitrosoglutathione, a NO donor, or glutathione without or with dibutyryl-cAMP (Bt2cAMP). NO regulated 110 transcripts that annotated dispro...
ORGANISM(S): Homo sapiens 
2007-09-11 | E-GEOD-2649 | biostudies-arrayexpress
ProteomicsInteraction of cGMP-dependent protein kinase and HAP1
Here, we use cAMP-based chemical proteomics approach, employing competitive concentrations of free cyclic nucleotides to isolate PKA and PKG and their secondary interactors.
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2015-02-09 | PXD001434 | Pride
Pkg Mass spectrometry Cgmp Gkap Chemical proteomics Hap1 
ProteomicsThe photoreceptor protective cGMP-analog Rp-8-Br-PET-cGMPS shows target-specificity in the degenerating mouse retina
The inherited eye disease Retinitis Pigmentosa (RP) causes the loss of photoreceptors by a still unknown cell death mechanism. During this degeneration, cGMP levels become elevated, leading to over-activation of the cGMP-binding protein cGMP-dependent protein kinase (PKG). cGMP analogs selectively m...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-07 | PXD031693 | Pride
Retinitis pigmentosa Mouse Retina Lc-ms/ms 
Genomics
CGMP
PRJEB18535 | ENA
TranscriptomicscGMP inducer effect on cell line Panc-1
cGMP is well-known secound messanger involved in vascular homeostasis. However little is known the effect of cGMP inducer on mRNA expression in cancer cells. We performed microarrays to revealed the transcriptional change of a human pancreatic ductal adenocarcinoma (PDCA) cell line (Panc -1) to cGMP...
ORGANISM(S): Homo sapiens 
2016-09-01 | GSE66403 | GEO
OtherHuntingtin associated protein (HAP1) is a cGMP-dependent kinase anchoring protein (GKAP), specific for the cGMP-dependent protein kinase Iβ isoform.
Data from ProteomeXchange, PXD ID: PXD001434. Published as part of J Biol Chem. 2015 Feb 4. pii . From the Abstract: {{i}} ... Here, we extend on this cAMP-based chemical proteomics approach, employing competitive concentrations of free cyclic nucleotides to isolate each kinase and its secondary in...
ORGANISM(S): Homo_sapiens_viruses, Human_female 
GPM32320007631 | GPMDB
Resource Reanalysis 
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