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ProteomicsPhosphoproteomic profiling of Neospora caninum tachyzoites and PKG inhibitor MBP146-78 treatment
In this study, phosphorylation levels of Neospora caninum parasite (Nc1 strains) tachyzoites were compared with PKG inhibitor MBP146-78 treated and untreated, contains two replicates. Therefore, four subprojects are included in this project. Subproject IPX0011618001 is composed of the sub-dataset ge...
ORGANISM(S): Neospora Caninum 
2025-04-09 | PXD062765 |
ProteomicsPlasmodium PKG interacts with ICM1, a multi-pass membrane protein, in both asexual and sexual stages
In malaria parasites, all cGMP-dependent signalling is mediated through a single cGMP-dependent protein kinase (PKG). A major function of PKG is to control calcium signals essential for the parasite to exit red blood cells or for transmission to the mosquito vector. However, how PKG controls these s...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2021-02-10 | PXD020447 | Pride
Lc-msms Malaria Cell signalling Calcium homeostasis Protein kinase g Orbitrap Plasmodium falciparum 
ProteomicsPKG-dependent phosphoproteome of T. gondii treated with the phosphodiesterase inhibitor zaprinast
Apicomplexans are ubiquitous parasites of humans and cause diseases including toxoplasmosis, malaria, and cryptosporidiosis. Protein kinase G (PKG) possesses unique features in this phylum of parasites and is a demonstrated drug target. Phosphodiesterase inhibitors increase the concentration of cGMP...
ORGANISM(S): Toxoplasma gondii RH 
2024-07-12 | PXD044361 | Pride
Toxoplasma Pkg Parasite T. gondii Phosphoproteomics Protein kinase g 
GenomicsIdentification of plant PKG in GA signaling via fine-tuning GAMYB nuclear localization
Identification of plant PKG in GA signaling via fine-tuning GAMYB nuclear localization
PRJNA487793 | ENA
ProteomicsA G-protein-coupled receptor modulates gametogenesis via PKG-mediated signaling cascade in Plasmodium berghei
Gametogenesis is essential for malaria parasite transmission, but the molecular mechanism of this process remains to be refined. Here, we identified a G-protein-coupled receptor 180 (GPR180) that plays a critical role in signal transduction during gametogenesis in Plasmodium. In the rodent parasite ...
ORGANISM(S): Plasmodium berghei ANKA 
2022-04-01 | PXD030837 | Pride
Gametogenesis G-protein-coupled receptors Cgmp-pkg- ca2+ signaling cascades Malaria 
ProteomicsActivation loop phosphorylation and cGMP saturation of PKG regulate egress of malaria parasites
The cGMP-dependent protein kinase (PKG) is the sole cGMP sensor in malaria parasites, acting as an essential signalling hub to govern key developmental processes throughout the parasite life cycle. Despite the importance of PKG in the clinically relevant asexual blood stages, many aspects of malaria...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2024-06-24 | PXD049083 | Pride
Phosphorylation Cgmp-dependent protein kinase Malaria Genetics Plasmodium falciparum 
ProteomicsActivation loop phosphorylation and cGMP saturation of PKG regulate egress of malaria parasites
The cGMP-dependent protein kinase (PKG) is the sole cGMP sensor in malaria parasites, acting as an essential signalling hub to govern key developmental processes throughout the parasite life cycle. Despite the importance of PKG in the clinically relevant asexual blood stages, many aspects of malaria...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2024-06-24 | PXD048979 | Pride
Phosphorylation Cgmp-dependent protein kinase Malaria Genetics Plasmodium falciparum 
TranscriptomicsIdentification of plant PKG in GA signaling via fine-tuning GAMYB nuclear localization
Through transcriptomic profiling, we compared differentially expressed genes between WT and pkg mutant treated with Br-cGMP, we found that PKG as primary receptor mediated cGMP signaling in rice.
ORGANISM(S): Oryza sativa 
2020-08-24 | GSE119028 | GEO
ProteomicsCross-talk between PKA and PKG controls pH-dependent host cell egress of Toxoplasma gondii
Toxoplasma gondii encodes three Protein Kinase A catalytic (PKAc1-3) and one regulatory (PKAr) subunits to integrate cAMP-dependent signals. Here, we show that inactive PKAc1 is maintained at the parasite pellicle by interacting with dually acylated PKAr. Either a conditional knockdown of PKAr or th...
ORGANISM(S): Toxoplasma gondii Toxoplasma gondii 
2017-10-12 | PXD006045 | Pride
Imac T. gondii Phospho Lc-msms 
UnknownScutellarin's Cardiovascular Endothelium Protective Mechanism: Important Role of PKG-Iα.
Not available
S-EPMC4594915 | biostudies-literature
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