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GenomicsDirect correction of haemoglobin E / beta-thalassaemia using base editors
Direct correction of haemoglobin E / beta-thalassaemia using base editors
PRJNA849199 | ENA
GenomicsHaemoglobin E beta thalassaemia in a patient group from Sri Lanka
Exome sequencing of 32 patient samples from Sri Lanka with the condition haemoglobin E beta thalassaemia
EGAS00001000626 | EGA
ProteomicsHaptoglobin is dispensable for haemoglobin uptake by Trypanosoma brucei
Trypanosoma brucei requires haemoglobin for survival in the mammalian bloodstream. Haptoglobin (Hp), a host protein known to bind haemoglobin, was determined as a key component for haemoglobin acquisition by the parasite. Here, we investigated the impact of haptoglobin deficiency on T. brucei brucei...
ORGANISM(S): Trypanosoma brucei brucei TREU927 Mus musculus (Mouse) 
2024-07-16 | PXD052778 | Pride
Blood parasite Hemoglobin Haptoglobin Trypanosoma brucei brucei Haptoglobin knock-out mouse 
OtherDirect correction of haemoglobin E / beta-thalassaemia using base editors
Haemoglobin E (HbE)/β-thalassaemia causes approximately 50% of all severe thalassaemia worldwide; equating to around 30,000 births per year. HbE/β-thalassaemia is due to a point mutation in codon 26 of the human HBB gene on one allele (GAG; glutamate → GAA; lysine, E26K), and any mutation causing se...
ORGANISM(S): Homo sapiens 
2023-01-25 | GSE206098 | GEO
TranscriptomicsTranscription profiling of Neisseria meningitidis strain MC58 grown on RPMI agar containing 10uM Transferrin, 10uM Lactoferrin, 1uM Haemoglobin, or 20uM Ferric chloride
Transcriptional profiling of Neisseria meningitidis strain MC58 grown on RPMI agar containing 10uM Transferrin, 10uM Lactoferrin, 1uM Haemoglobin, or 20uM Ferric chloride.
ORGANISM(S): Neisseria meningitidis 
2009-02-25 | E-MEXP-1143 | biostudies-arrayexpress
UnknownFetal haemoglobin levels and haematological characteristics of compound heterozygotes for haemoglobin S and deletional hereditary persistence of fetal haemoglobin.
Not available
S-EPMC6605093 | biostudies-literature
ProteomicsSystem-wide biochemical analysis reveals ozonide and artemisinin antimalarials initially act by disrupting malaria parasite haemoglobin digestion
Artemisinins are currently the first-line antimalarials, and rely on a peroxide pharmacophore for their potent activity. OZ277 (arterolane) and OZ439 (artefenomel) are newer synthetic peroxide-based antimalarials with potent activity against the deadliest malaria parasite, Plasmodium falciparum. Her...
ORGANISM(S): Homo sapiens (Human) Plasmodium falciparum (isolate 3D7) 
2020-05-25 | PXD014313 | Pride
Metabolomics Peptidomics Peroxide antimalarial Malaria Proteomics Plasmodium falciparum 
UnknownEvolutionary diversification of the trypanosome haptoglobin-haemoglobin receptor from an ancestral haemoglobin receptor.
Not available
S-EPMC4889325 | biostudies-literature
UnknownPirates of the haemoglobin.
Not available
S-EPMC8977872 | biostudies-literature
UnknownAnalysis of Mitochondrial haemoglobin in Parkinson's disease brain.
Not available
S-EPMC4940210 | biostudies-literature
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