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ProteomicsIntact N-glycopeptides in Serum Haptoglobin between HCC and Cirrhosis
A workflow for differential analysis of the microheterogeneity of site-specific intact N-glycopeptides of serum haptoglobin between early hepatocellular carcinoma (HCC) and liver cirrhosis has been developed.
ORGANISM(S): Homo sapiens (Human) 
2018-10-25 | PXD011239 | Pride
Human Serum Haptoglobin Lc-ethcd-ms/ms Liver 
ProteomicsPRM-MS quantitative analysis of isomeric N-glycopeptides derived from human serum haptoglobin of patients with cirrhosis and hepatocellular carcinoma
Comprehensive LC-PRM-MS approach where a targeted parallel reaction monitoring (PRM) strategy was coupled to a powerful LC system to study the microheterogeneity of serum haptoglobin (Hp) extracted from 15 patients with cirrhosis and 15 with hepatocellular carcinoma (HCC).
ORGANISM(S): Homo sapiens (Human) 
2021-09-10 | PXD023719 | Pride
N-glycopeptides Prm Hepatocellular carcinoma (hcc) Haptoglobin Cirrhosis 
TranscriptomicsMicroarray identification of functional modules involving Haptoglobin and/or Hemopexin
Haptoglobin and Hemopexin are plasma acute phase proteins that bind with high affinity hemoglobin and heme, respectively. Several studies have demonstrated that they have a key role in the protection against oxidative stress and inflammation. However, little is known about the functional modules in ...
ORGANISM(S): Mus musculus 
2006-10-31 | E-GEOD-3656 | biostudies-arrayexpress
ProteomicsGlycopeptide Biomarkers for HCC Detection in Patients with NASH
A comprehensive screening of site-specific N-glycopeptides in serum haptoglobin (Hp), a reporter molecule for aberrant glycosylation in HCC, has been performed to characterize glycopeptide markers for NASH-related HCCs.
ORGANISM(S): Homo sapiens (Human) 
2020-05-22 | PXD018502 | Pride
Human Serum Glycopeptide Lc-ethcd-ms/ms 
ProteomicsHydroxyl radical footprinting analysis of a human haptoglobin-hemoglobin complex
Methods of structural mass spectrometry have become more popular to study protein structure and dynamics. Among them, fast photochemical oxidation of proteins (FPOP) has several advantages such as irreversibility of modifications and more facile determination of the site of modification with single ...
ORGANISM(S): Homo sapiens (Human) 
2021-12-30 | PXD021621 | Pride
Footprinting Hemoglobin Haptoglobin Fpop Timstof pro 
GenomicsEffect of haptoglobin (purified from human serum) on gene expression in monocyte-derived macrophages.
Effect of haptoglobin (purified from human serum) on gene expression in monocyte-derived macrophages.
PRJNA891280 | ENA
TranscriptomicsMicroarray identification of functional modules involving Haptoglobin and/or Hemopexin
Haptoglobin and Hemopexin are plasma acute phase proteins that bind with high affinity hemoglobin and heme, respectively. Several studies have demonstrated that they have a key role in the protection against oxidative stress and inflammation. However, little is known about the functional modules in ...
ORGANISM(S): Mus musculus 
2006-11-01 | GSE3656 | GEO
ProteomicsHaptoglobin is dispensable for haemoglobin uptake by Trypanosoma brucei
Trypanosoma brucei requires haemoglobin for survival in the mammalian bloodstream. Haptoglobin (Hp), a host protein known to bind haemoglobin, was determined as a key component for haemoglobin acquisition by the parasite. Here, we investigated the impact of haptoglobin deficiency on T. brucei brucei...
ORGANISM(S): Trypanosoma brucei brucei TREU927 Mus musculus (Mouse) 
2024-07-16 | PXD052778 | Pride
Blood parasite Hemoglobin Haptoglobin Trypanosoma brucei brucei Haptoglobin knock-out mouse 
TranscriptomicsEffect of haptoglobin (purified from human serum) on gene expression in monocyte-derived macrophages.
Haptoglobin is a major serum protein that sequesters free hemoglobin. Moreover, haptoglobin regulates the inflammatory response in the absence of hemoglobin. Conflicting functional outcomes are reported, whereas involvement of NFκB is suggested consistently. Our data indicate that purified haptoglob...
ORGANISM(S): Homo sapiens 
2022-10-24 | GSE215916 | GEO
ProteomicsHaptoglobin and glutamine synthetase as potential biomarkers of chemotherapy-induced cachexia in skeletal muscle
Cancer cachexia is a multifactorial wasting syndrome affecting body and lean tissue mass that is often exacerbated by anticancer chemotherapy. In this study, we used a mouse model of acute myeloid leukemia chemotherapy induction regimen (CIR) comprising daunorubicin and cytarabine to investigate the...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-16 | PXD063910 | Pride
Cancer cachexia Proteomics Skeletal muscle wasting Glutamine synthetase Tmt Mitochondrial metabolism Acute myeloid leukemia Haptoglobin Chemotherapy Biomarkers Aml 
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