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MetabolomicsTranscriptomic and metabolomic analysis of liver cirrhosis
Liver cirrhosis is one of the leading causes of decreased life expectancy worldwide. However, the molecular mechanisms underlying the development of liver cirrhosis remain unclear. In this study, we performed a comprehensive analysis using transcriptome and metabolome sequencing to explore the genes...
2024-08-07 | MTBLS5665 | MetaboLights
MetabolomicsUtilization of metabolomics to identify serum biomarkers for hepatocellular carcinoma in patients with liver cirrhosis
Characterizing the metabolic changes pertaining to hepatocellular carcinoma (HCC) in patients with liver cirrhosis is believed to contribute towards early detection, treatment, and understanding of the molecular mechanisms of HCC. In this study, we compare metabolite levels in sera of 78 HCC cases w...
MTBLS17 | MetaboLights
MetabolomicsMetabolomics biomarkers of hepatocellular carcinoma in a prospective cohort of patients with cirrhosis

BACKGROUND & AIMS: The effectiveness of surveillance for hepatocellular carcinoma (HCC) in patients with cirrhosis is limited, due to inadequate risk stratification and suboptimal performance of current screening modalities.

METHODS: We developed a mult...

2024-05-09 | MTBLS8764 | MetaboLights
TranscriptomicsPrognostic Gene-Expression Signature for Patients with Hepatitis CRelated Early-Stage Cirrhosis
Gene-expression profiles of hepatitis C-related, early-stage liver cirrhosis Background & Aims: Liver cirrhosis affects 1%M-bM-^HM-^R2% of population and is the major risk factor of hepatocellular carcinoma (HCC). Hepatitis C cirrhosis-related HCC is the most rapidly increasing cause of cancer deat...
ORGANISM(S): Homo sapiens 
2013-01-22 | E-GEOD-15654 | biostudies-arrayexpress
ProteomicsQuantitative proteome analysis of plasma microparticles for characterization of HCV-induced hepatic cirrhosis and hepatocellular carcinoma
A quantitative label-free proteome analysis was performed using plasma samples from 22 hepatitis-C virus (HCV)-induced liver cirrhosis patients, 16 HCV-positive hepatocellular carcinoma patients with underlying cirrhosis and 18 healthy controls. Plasma microparticles (PMPS) were isolated using ultra...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-03-12 | MSV000085094 | MassIVE
TranscriptomicsExpression profiles of 186-gene signature in U.S. hepatitis C virus (HCV)-related liver cirrhosis
OBJECTIVE: The number of patients with HCV-related cirrhosis is increasing, leading to a rising risk of complications and death. Prognostic stratification in patients with early-stage cirrhosis is still challenging. We aimed to develop and validate a clinically useful prognostic index based on genom...
ORGANISM(S): Homo sapiens 
2014-08-22 | E-GEOD-54100 | biostudies-arrayexpress
TranscriptomicsExpression profiles of 186-gene signature in Italian hepatitis C virus (HCV)-related liver cirrhosis
OBJECTIVE: The number of patients with HCV-related cirrhosis is increasing, leading to a rising risk of complications and death. Prognostic stratification in patients with early-stage cirrhosis is still challenging. We aimed to develop and validate a clinically useful prognostic index based on genom...
ORGANISM(S): Homo sapiens 
2014-08-22 | E-GEOD-54099 | biostudies-arrayexpress
TranscriptomicsDifferent CircRNAs expression profiles between the HCC and liver cirrhosis
Background: Of Hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), 85%-90% of cases develop from liver cirrhosis, and circular RNAs (circRNAs) have important roles in this process; however, differences in serum circRNA expression profiles between patients with HBV-related cirrhosis and t...
ORGANISM(S): Homo sapiens 
2025-02-10 | E-MTAB-12717 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat cirrhotic liver treated with angiogenesis inhibitors
Background and aims: There are considerable evidences demonstrating that angiogenesis and chronic inflammation are mutually dependent. However, although cirrhosis progression is characterized with a chronic hepatic inflammatory process, this connection is not sufficiently explored as a therapeutic s...
ORGANISM(S): Rattus norvegicus 
2008-06-15 | E-GEOD-6929 | biostudies-arrayexpress
ProteomicsBiomarkers of hepatocellular synthesis predict mortality in patients with decompensated cirrhosis
Background & Aims: Since liver hepatocytes produce the majority of serum proteins, liver cirrhosis displays a massive alteration in serum proteome. The aim of the current study was to characterize these alterations and to study the prognostic usefulness of hepatocellular proteins available in routin...
ORGANISM(S): Homo sapiens (Human) 
2023-11-20 | PXD035024 | Pride
Biomarker Serum Human Cirrhosis Lc-ms/ms 
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