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ProteomicsThe bZIP transcription factor HapX is post-translationally regulated to control iron homeostasis in Aspergillus fumigatus
The airborne fungus Aspergillus fumigatus causes opportunistic infections in humans with high mortality rates in immunocompromised patients. Previous work established that the bZIP transcription factor HapX is essential for virulence via adaptation to iron limitation by repressing iron-consuming pat...
ORGANISM(S): Neosartorya fumigata (Aspergillus fumigatus) 
2021-07-20 | PXD026889 | Pride
Hapx Aspergillus fumigatus Post-translational modifications Iron homeostasis Lc-ms/ms 
TranscriptomicsHapX positively and negatively regulates the transcriptional response to iron deprivation in Cryptococcus neoformans
Analysis of the transcriptional response of C. neoformans WT, cir1 mutant, hap3 mutant and hapX mutant to different iron sources. The following experimental design was adopted for the study. Within each strain, each treatment pair (low-iron, +FeCl3, +Transferrin and +Hemin; 6 pairs) were hybridized ...
ORGANISM(S): Cryptococcus neoformans 
2011-04-13 | E-GEOD-22988 | biostudies-arrayexpress
TranscriptomicsAspergillus fumigatus HapX-mediated iron starvation adaption is required for virulence.
Iron is an essential cofactor for a wide range of cellular processes. Previous studies have shown that siderophore-mediated uptake and intracellular handling of iron are crucial for virulence of Aspergillus fumigatus. Here we show that the bzip-type transcription factor HapX plays a crucial role in ...
ORGANISM(S): Aspergillus fumigatus Af293 Aspergillus fumigatus 
2010-07-01 | GSE22052 | GEO
TranscriptomicsAspergillus fumigatus HapX-mediated iron starvation adaption is required for virulence.
Iron is an essential cofactor for a wide range of cellular processes. Previous studies have shown that siderophore-mediated uptake and intracellular handling of iron are crucial for virulence of Aspergillus fumigatus. Here we show that the bzip-type transcription factor HapX plays a crucial role in ...
ORGANISM(S): Aspergillus fumigatus 
2010-07-01 | E-GEOD-22052 | biostudies-arrayexpress
UnknownHapX-mediated adaption to iron starvation is crucial for virulence of Aspergillus fumigatus.
Not available
S-EPMC2947994 | biostudies-literature
GenomicsThe fungal CCAAT-binding complex and HapX display highly variable but evolutionary conserved synergetic promoter-specific DNA recognition
To sustain iron homeostasis, microorganisms have evolved fine-tuned mechanisms for uptake, storage and detoxification of the essential metal iron. In the human pathogen Aspergillus fumigatus, the fungal-specific bZIP-type transcription factor HapX coordinates adaption to both iron starvation and iro...
ORGANISM(S): Aspergillus fumigatus 
2019-12-31 | GSE129969 | GEO
UnknownThe bZIP Transcription Factor HapX Is Post-Translationally Regulated to Control Iron Homeostasis in Aspergillus fumigatus.
Not available
S-EPMC8307855 | biostudies-literature
UnknownHapX positively and negatively regulates the transcriptional response to iron deprivation in Cryptococcus neoformans.
Not available
S-EPMC2991262 | biostudies-literature
UnknownThe Janus transcription factor HapX controls fungal adaptation to both iron starvation and iron excess.
Not available
S-EPMC4232046 | biostudies-literature
GenomicsThe fungal CCAAT-binding complex and HapX display highly variable but evolutionary conserved synergetic promoter-specific DNA recognition
The fungal CCAAT-binding complex and HapX display highly variable but evolutionary conserved synergetic promoter-specific DNA recognition
PRJNA533305 | ENA
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