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ProteomicsThe proteomics analysis of mitochondria-enriched fractions reveals alteration of key mitochondrial pathways in breast cancer cell lines
Breast cancer is the leading cause of death in women worldwide. Plasticity and heterogeneity of breast cancer cells make this disease extremely difficult to treat. Many reports point to metabolic shifts, mainly those carried out in o mitochondria, as key processes governing the behavior and heteroge...
ORGANISM(S): Homo sapiens (Human) 
2026-04-27 | PXD069883 | Pride
T47d and mda-mb-231 breast cancer cell lines  healthy breast mcf-12f cell line  mitochondria  differentially expressed proteins  label-free proteomics analysis 
ProteomicsLabel-free proteomics analysis of mixed membrane fractions isolated from triple negative breast cancer cell lines with different TNM stages compared to a healthy breast cell line revealed profound metabolic reprogramming and coordinated upregulation of Warburg effect machinery and suppression of OXPHOS components
Triple-negative breast cancer (TNBC) represents the most aggressive breast cancer subtype with limited therapeutic options and the poorest clinical outcomes. Using high-resolution nUPLC-QTOF-MS/MS, we performed comprehensive proteomics profiling of TNBC cell lines representing disease progression st...
ORGANISM(S): Homo sapiens (Human) 
2026-10-19 | PXD071351 | Pride
Tnbc lines  tnm stage  label-free quantitative proteomics  differentially protein abundance  protein-biomarkers 
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