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ModelsSivakumar2011 - Hedgehog Signaling Pathway
Sivakumar2011 - Hedgehog Signaling Pathway This is the current model for the Hedgehog signaling pathway. The best data for mechanism of signaling has been worked out in Drosophila, so this model is based largely on Drosophila data. Hedgehog target genes vary from tissue to tissue, so the ident...
2024-09-02 | BIOMD0000000395 | BioModels
ProteomicsInactivation of p21-Activated Kinase 2 (Pak2) Inhibits the Development of Nf2-Deficient Tumors by Restricting Downstream Hedgehog and Wnt Signaling
Since loss of the NF2 tumor suppressor gene results in p21-activated kinase (Pak) activation, PAK inhibitors hold promise for the treatment of NF2-deficient tumors. To test this possibility, we asked if loss of Pak2, a highly expressed group I PAK member, affects the development of malignant mesothe...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-10 | PXD030571 | Pride
Conditional knockout mice  malignant mesothelioma  nf2 and cdkn2a tumor suppressor genes  pak  hedgehog and wnt signaling  cancer stem cells 
ProteomicsCo-activation of Sonic hedgehog and Wnt signaling in murine retinal precursor cells drives ocular lesions with features of intraocular medulloepithelioma
Intraocular medulloepithelioma (IO-MEPL) is a rare embryonal ocular neoplasm, prevalently occurring in children. IO-MEPL share histomorphological features with CNS embryonal tumors with multilayered rosettes (ETMR), referred to as intracranial medulloepitheliomas. While Sonic hedgehog (SHH) and WNT ...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-15 | PXD028697 | Pride
Cancer Mouse model Hedghog signaling Intraocular medulloepethelioma Bottom up Wnt signaling 
ProteomicsFibroblast-derived Smoothened governs prognosis of acute kidney injury
Although the tubule is the epicenter of damage, kidney fibroblast is increasingly appreciated in governing the prognosis of acute kidney injury (AKI). Smoothened (Smo), a heptahelical transmembrane protein, carries a hedgehog signal to mediate the communications between kidney fibroblasts and tubula...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2021-12-23 | MSV000088609 | MassIVE
ModelsMorpheus model of spatio-temporal liver zonation from Wnt-Hh crosstalk
Morpheus model of spatio-temporal liver zonation from Wnt-Hh crosstalk
2020-11-27 | 759 | FAIRDOMHub
ModelsSivakumar2011 - Notch Signaling Pathway
Sivakumar2011 - Notch Signaling Pathway Notch is a transmembrane receptor that mediates local cell-cell communication and coordinates a signaling cascade. It plays a key role in modulating cell fate decisions throughout the development of invertebrate and vertebrate species and the misregulati...
2024-09-02 | BIOMD0000000396 | BioModels
TranscriptomicsDifferential Wnt and Hh signaling in head and growth zone of a short germ embryo
Purpose: Combination of systemic RNAi with RNAseq to identify target genes of important pathways in early development Drosophila early patterning occurs in the syncytial blastoderm where transcription factors diffuse between cells. However, in typical insect embryos, patterning occurs in a cellulari...
ORGANISM(S): Tribolium castaneum 
2014-02-06 | E-GEOD-54706 | biostudies-arrayexpress
UnknownHedgehog and Wnt Signaling Pathways Regulate Tail Regeneration.
Not available
S-EPMC6205047 | biostudies-literature
UnknownDisrupting hedgehog and WNT signaling interactions promotes cleft lip pathogenesis.
Not available
S-EPMC3973078 | biostudies-literature
GenomicsRunx2 regulates cranial suture closure by regulating hedgehog, Fgf, Wnt, and Pthlh signaling pathway genes in suture mesenchymal cells
Runx2 regulates cranial suture closure by regulating hedgehog, Fgf, Wnt, and Pthlh signaling pathway genes in suture mesenchymal cells
PRJNA489457 | ENA
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