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TranscriptomicsThe HDAC inhibitor Givinostat modulates key hematopoietic genes in JAK2V617F cells, affecting proliferation, differentiation and apoptosis
We investigated the mechanism of action of the HDAC inhibitor Givinostat in JAK2V617F cells. We confirm that the drug inhibits colony formation and proliferation and induces apoptosis at doses 2-3 fold lower in JAK2V617F (HEL, UKE1 and SET2) compared to JAK2 wild type cell lines (K562, KU812, THP1 a...
ORGANISM(S): Homo sapiens 
2012-07-16 | E-GEOD-27615 | biostudies-arrayexpress
GenomicsSulfitobacter indolifex HEL-45
Marine bacterium
PRJNA19327 | ENA
TranscriptomicsIntegrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis [HEL cell lines]
We used expression profiling, SNP arrays, and mutational profiling to investigate a well-characterized cohort of MPN patients. MPN patients with homozygous JAK2V617F mutations were characterized by a distinctive transcriptional profile. Notably, a transcriptional signature consistent with activated ...
ORGANISM(S): Homo sapiens 
2014-06-03 | E-GEOD-54645 | biostudies-arrayexpress
GenomicsFGF12-overexpression HEL cell line
FGF12-overexpression HEL cell line
PRJNA1416964 | ENA
Transcriptomicsgene expression data from cep701 treated HEL cells and shPRMT5 knocking down HEL cells
compare the gene expression profile between cep701 treated HEL cells with shPRMT5 knockingdown HEL cells. HEL cells contain homologous alells with mutation Jak2V617F. We found JAK2V617F can inactivate PRMT5 activity by directly phosphorylating PRMT5 through histone methylation.
ORGANISM(S): Homo sapiens 
2011-01-01 | GSE25725 | GEO
GenomicsEffect of TMIGD2 knockdown on gene expression in HEL cell line
Effect of TMIGD2 knockdown on gene expression in HEL cell line
PRJNA885492 | ENA
GenomicsGenome-wide occupancy of LSD1 in HEL human erythroleukemia cell line.
Genome-wide occupancy of LSD1 in HEL human erythroleukemia cell line.
PRJNA607086 | ENA
GenomicsHEL cell line methylation analysis
Whole human genome methylation analysis of the HEL cell line using nanopore sequencing
PRJEB44972 | ENA
GenomicsExpression data of HEL cells with or without LY2784544 and GRN163L
Expression data of HEL cells with or without LY2784544 and GRN163L
PRJNA594024 | ENA
GenomicsEffect of LSD1 knockdown on histone H3K4 methylation in HEL human erythroleukemia cell line.
Effect of LSD1 knockdown on histone H3K4 methylation in HEL human erythroleukemia cell line.
PRJNA607081 | ENA
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