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ProteomicsOsteomacs promote maintenance of murine hematopoiesis through megakaryocyte-induced upregulation of Embigin and CD166
Maintenance of hematopoietic stem cell (HSC) function in the niche is an orchestrated event. Osteomacs (OM), are key cellular components of the niche. Previously, we documented that osteoblasts, OM, and megakaryocytes interact to promote hematopoiesis. Here, we further characterize OM and identify m...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-01-11 | MSV000093840 | MassIVE
TranscriptomicsDensely interconnected transcriptional circuits control cell states in human hematopoiesis
Tremendous progress has been made in identifying individual transcription factors that regulate hematopoietic differentiation, but many aspects of the global architecture of hematopoiesis remain unknown. Here, we profiled gene expression in 38 distinct purified populations of human hematopoietic cel...
ORGANISM(S): Homo sapiens 
2011-01-21 | E-GEOD-24759 | biostudies-arrayexpress
TranscriptomicsMolecular mechanism behind the hematopoiesis-enhancing effect of SRT3025
We used wild-type 129 mice to understand the mechanism of action behind SRT3025’s hematopoiesis-enhancing effect. Transcriptome analysis of cKit+ Sca1+ Lin- cells (KSL) cells discovered that a list of genes changed their expression levels significantly after SRT3025 administration in wild-type mice....
ORGANISM(S): Mus musculus 
2015-07-04 | E-GEOD-60941 | biostudies-arrayexpress
TranscriptomicsMusashi 2 regulates normal hematopoiesis and accelerates leukemogenesis
This SuperSeries is composed of the following subset Series: GSE16432: MSI2 regulates hematopoiesis and accelerates leukemogenesis GSE22773: Musashi 2 regulates normal hematopoiesis and accelerates leukemogenesis (LK and MS12-inducible) GSE22774: Musashi 2 regulates normal hematopoiesis and accelera...
ORGANISM(S): Homo sapiens 
2010-07-21 | E-GEOD-22778 | biostudies-arrayexpress
TranscriptomicsRUNX1B expression distinguishes megakaryocytic and erythroid lineage fate in adult hematopoiesis
The Core Binding Factor (CBF) protein RUNX1 is a master regulator of definitive hematopoiesis, crucial for hematopoietic stem cell (HSC) emergence during ontogeny, which also plays vital roles in adult mice, in regulating the correct specification of numerous blood lineages. Akin to the other mamma...
ORGANISM(S): Mus musculus 
2016-01-04 | E-GEOD-68958 | biostudies-arrayexpress
GenomicsAutophagy driven by a master regulator of hematopoiesis
Developmental and homeostatic remodeling of cellular organelles is mediated by a complex process termed autophagy. The cohort of proteins that constitute the autophagy machinery function in a multistep biochemical pathway. Though components of the autophagy machinery are broadly expressed, autophagy...
ORGANISM(S): Homo sapiens 
2011-09-30 | E-GEOD-32491 | biostudies-arrayexpress
GenomicsPRR14L mutations are associated with chromosome 22 acquired uniparental disomy, age related clonal hematopoiesis and myeloid neoplasia
Whole exome sequencing of 5 MDS/MPN patients to identify the target of chromosome 22 acquired uniparental disomy (22aUPD). For samples E4051 and E6523, peripheral blood leucocytes (tumour) and cultured T-cells (germline) were prepared for exome sequencing using the Agilent SureSelect kit (Agilent Te...
ORGANISM(S): Homo sapiens 
2019-01-22 | E-MTAB-7491 | biostudies-arrayexpress
GenomicsA Cdx4-Sall4 regulatory module controls the transition from mesoderm formation to embryonic hematopoiesis
Deletion of caudal/cdx genes alters hox gene expression and causes defects in posterior tissues and hematopoiesis. Yet, the defects in hox gene expression only partially explain these phenotypes. To gain deeper insight into Cdx4 function, we performed ChIP-seq combined with gene expression profiling...
ORGANISM(S): Danio rerio 
2013-12-02 | E-GEOD-48254 | biostudies-arrayexpress
TranscriptomicsThe role of Ldb1 in hemangioblast development: genome-wide analysis shows that Ldb1 controls essential hematopoietic genes/pathways in mouse early development and reveals novel players in hematopoiesis (sequencing)
The first site exhibiting hematopoietic activity in mammalian development is the yolk sac blood island, which originates from the hemangioblast. Here we performed differentiation assays, as well as genome-wide molecular and functional studies in BL-CFCs to gain insight into the function of the essen...
ORGANISM(S): Mus musculus 
2013-02-09 | E-GEOD-43041 | biostudies-arrayexpress
TranscriptomicsThe role of Ldb1 in hemangioblast development: genome-wide analysis shows that Ldb1 controls essential hematopoietic genes/pathways in mouse early development and reveals novel players in hematopoiesis (Affymetrix)
The first site exhibiting hematopoietic activity in mammalian development is the yolk sac blood island, which originates from the hemangioblast. Here we performed differentiation assays, as well as genome-wide molecular and functional studies in BL-CFCs to gain insight into the function of the essen...
ORGANISM(S): Mus musculus 
2013-02-09 | E-GEOD-43042 | biostudies-arrayexpress
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