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TranscriptomicsComparing Control and Schizophrenic hiPSC-derived Neurons
Schizophrenia is a debilitating neurological disorder for which no cure exists. Few defining characteristics of schizophrenic neurons have been identified and the molecular mechanisms responsible for schizophrenia are not well understood, in part due to the lack of patient material for study. Human ...
ORGANISM(S): Homo sapiens 
2011-05-01 | E-GEOD-25673 | biostudies-arrayexpress
TranscriptomicsNext Generation Sequencing Facilitates Comparisons of Control and Schizophrenia-Patient derived hiPSC-derived NPCs
Cell-based models of many neurological and psychiatric diseases, established by reprogramming patient somatic cells into human induced pluripotent stem cells (hiPSCs), have now been reported. While numerous reports have demonstrated that neuronal cells differentiated from hiPSCs are electrophysiolo...
ORGANISM(S): Homo sapiens 
2016-03-14 | E-GEOD-63738 | biostudies-arrayexpress
TranscriptomicsComparing Control and Schizophrenic hiPSC-derived NPCs
Cell-based models of many neurological and psychiatric diseases, established by reprogramming patient somatic cells into human induced pluripotent stem cells (hiPSCs), have now been reported. While numerous reports have demonstrated that neuronal cells differentiated from hiPSCs are electrophysiolo...
ORGANISM(S): Homo sapiens 
2014-04-01 | E-GEOD-40102 | biostudies-arrayexpress
TranscriptomicshiPSC-derived motor neurons: sporadic ALS patients vs. controls
Differentiated motor neurons from hiPSC derived from peripheral nerve fibroblasts of sporadic ALS patients and evaluated the gene expression profile by means microarray-linked to specific analysis tools. Two-condition experiment, ALS patients motor neurons vs. controls. Biological replicates: 3 ALS ...
ORGANISM(S): Homo sapiens 
2015-04-25 | E-GEOD-68240 | biostudies-arrayexpress
TranscriptomicsSNP array analysis of single cell genomes
This study (McConnell, et al. Science 2012) used both SNP array and sequencing data to examine copy number variation in neuronal genomes. Encolsed here are the SNP Array data from the 42 fibroblasts, 19 human induced pluripotent stem cell (hiPSC)-derived neural progenitor cells (NPCs), and 40 hiPSC-...
ORGANISM(S): Homo sapiens 
2013-12-04 | E-GEOD-51538 | biostudies-arrayexpress
GenomicsChromatin accessibility changes in hiPSC-derived neurons after BDNF and KCl stimulations
Brain-Derived Neurotrophic Factor (BDNF) is crucial for neuronal survival, differentiation, synaptic plasticity, memory formation, and neurocognitive health. Molecular mechanisms of BDNF promoting cellular survival and synaptic plasticity have been intensely studied, yet its role in genome regulatio...
EGAS00001006394 | EGA
ProteomicsProteomics profile of rabies virus-infected hiPSC-derived neurons
Whole cell lysates from hiPSC-derived neurons infected with Thai strain rabies virus were obtained and proteins were analyzed by Nano-liquid chromatography and tandem mass-spectrometry (Nano LC-MS/MS). A comprehensive analysis of proteomic data provided remarkable cellular perturbations and signific...
ORGANISM(S): Homo Sapiens (human) 
2021-09-13 | PXD028449 | JPOST Repository
ProteomicsLiver Steatosis and Mitochondrial Dysfunction in Spinal Muscular Atrophy is Survival Motor Neuron-Dependent and Hepatocyte-Intrinsic
Spinal Muscular Atrophy (SMA) is typically characterized as a motor neuron disease, but extra-neuronal phenotypes are present in almost every organ in severely affected patients and animal models. Extra-neuronal phenotypes were previously underappreciated as patients with severe SMA phenotypes usual...
ORGANISM(S): Homo Sapiens (human) 
2024-05-09 | PXD045401 | JPOST Repository
TranscriptomicsGlobal gene expression profile and splicing events of iPS-derived motorneurons from SMA patient, unaffected father and TGC-treated cells
Spinal Muscular Atrophy (SMA) is an autosomal recessive motor neuron disease and is the second most common genetic disorder leading to death in childhood. Motoneurons derived from induced pluripotent stem cells (iPSC) obtained by reprogramming SMA patient and his healthy father fibroblasts, and gene...
ORGANISM(S): Homo sapiens 
2013-01-04 | E-GEOD-27205 | biostudies-arrayexpress
GenomicsExamining serotonergic neuron differentiation from human iPSCs
Examining serotonergic neuron differentiation from human iPSCs
PRJNA483556 | ENA
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