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TranscriptomicsDietary calcium inhibits colitis development in HLA-B27 transgenic rats
Background and Aims: We have shown in several controlled rat and human infection studies that dietary calcium improves intestinal resistance and strengthens the mucosal barrier. Reinforcement of gut barrier function is also relevant for inflammatory bowel disease (IBD). Therefore, we investigated th...
ORGANISM(S): Rattus norvegicus 
2009-07-16 | E-GEOD-11022 | biostudies-arrayexpress
ProteomicsHLA B-27 rats peptidome - The HLA-B27 peptidome in vivo in spondyloarthritis-susceptible HLA-B27 transgenic rats and the effect of ERAP1 deletion
HLA-B27 is a class I major histocompatibility (MHC-I) allele that confers susceptibility to the rheumatic disease ankylosing spondylitis (AS) by an unknown mechanism. ERAP1 is an aminopeptidase that trims peptides in the endoplasmic reticulum for binding to MHC-I molecules. ERAP1 shows genetic epist...
ORGANISM(S): Rattus norvegicus (Rat) 
2017-02-13 | PXD005502 | Pride
Transgenic rats Hla-b27 Peptidome Ankylosing spondylitis Human leukocytes antigen 
ProteomicsHLA-B27 interferes with TGF-/activin signaling in Drosophila and rat transgenic models, resulting in pathogenic consequences relevant for spondyloarthritis.
Background The striking association of HLA-B27 with spondyloarthritis (SpA) has been known for 50 years. However, its pathophysiological significance remains incompletely understood. In the HLA-B27/human-β2 microglobulin (hβ2m) transgenic rat (B27 rat) that spontaneously develops inflammatory pheno...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2024-10-17 | PXD047119 | Pride
Hla peptidome Spondyloarthritis  bmp/tgfβ pathway  hla-b27  cd4+ t cells  rat  drosophila 
GenomicsIntra-ocular dendritic cells characterize HLA-B27-associated acute anterior uveitis
Intra-ocular dendritic cells characterize HLA-B27-associated acute anterior uveitis
PRJNA741216 | ENA
ProteomicsDegradation of misfolded HLA B*2704 (associated with disease) involves UPR, autophagy and aggresomes whereas degradation of HLA B*2709 (non-associated with disease) involves the endosomal-lysosomal pathway
Ankylosing spondylitis (AS) belongs to a group of diseases, called spondyloarthropathies (SpA), which are strongly associated with the genetic marker, HLA-B27. AS is characterized by inflammation of joints, and primarily affects the spine. Over 200 subtypes of HLA B27 are known, owing to high polymo...
ORGANISM(S): Homo sapiens (Human) 
2021-12-23 | PXD027999 | Pride
Hla-b27  disease association  subtypes 
GenomicsGut microbiome in HLA B27 positive humans with anterior uveitis and HLA B27 negative controls
Associations of the Intestinal Microbiome and HLA-B27-associated anterior uveitis
PRJEB55787 | ENA
TranscriptomicsIntra-ocular dendritic cells characterize HLA-B27-associated acute anterior uveitis
Uveitis describes a heterogeneous group of inflammatory eye diseases characterized by infiltration of leukocytes into the uveal tissues. uveitis associated with the HLA haplotype B27 (HLA-B27) is a common subtype of uveitis and a prototypical ocular immune-mediated disease. Local immune mechanisms d...
ORGANISM(S): Homo sapiens 
2021-06-25 | GSE178833 | GEO
TranscriptomicsSingle cell RNAseq of ankylosing spondylitis lymphocytes from peripheral blood and synovial fluid
Single-cell transcriptome of >55,000 cells multiplexed into 4 channels obtained from peripheral blood and synovial fluid of two patients with HLA-B27+ ankylosing spondylitis,.
ORGANISM(S): Homo sapiens 
2021-10-18 | E-MTAB-10948 | biostudies-arrayexpress
TranscriptomicsChronic colitis in Bacteroides Thetaiotaomicron-Monoassociated HLA-B27 Transgenic rats alters expression of receptor and metabolic genes in luminal bacteria.
Background: Inflammatory bowel diseases (IBD) may be caused in part by aberrant immune responses to commensal intestinal microbes including Bacteroides thetaiotaomicron (B.theta). Healthy, germ-free HLA-B27 transgenic (Tg) rats develop chronic colitis when colonized with complex gut commensal bacte...
ORGANISM(S): Bacteroides thetaiotaomicron 
2012-01-11 | E-GEOD-34966 | biostudies-arrayexpress
GenomicsRapamycin treatment ameliorates HLA-B27-mediated gut inflammation and alters the microbiome in experimental spondyloarthritis
Rapamycin treatment ameliorates HLA-B27-mediated gut inflammation and alters the microbiome in experimental spondyloarthritis
PRJNA1330159 | ENA
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