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ProteomicsDepletion of the RNA binding protein HNRNPD impairs homologous recombination by inhibiting DNA-end resection and inducing R-loop accumulation
DNA double strand break (DSB) repair through homologous recombination (HR) is crucial to maintain genome stability. DSB resection generates a single strand DNA intermediate, which is crucial for the HR process. We used a synthetic DNA structure, mimicking a resection intermediate, as a bait to ident...
ORGANISM(S): Homo sapiens (Human) 
2019-02-26 | PXD012045 | Pride
Rna binding proteins  hnrnpd  dna damage  dna end resection  rna binding proteins  r-loop 
GenomicsHigh-throughput sequencing in HNRNPD knock-out SW839 cell lines
High-throughput sequencing in HNRNPD knock-out SW839 cell lines
PRJNA1005919 | ENA
TranscriptomicsHigh-throughput sequencing in HNRNPD knock-out SW839 cell lines
As HNRNPD regulates the alternative splicing of hundreds of genes, we sought to investigate whether HNRNPD could regulate the biogenesis of circRNAs. To identify the effect of HNRNPD on circRNAs, we performed circRNA sequencing in HNRNPD knockout and wild-type SW839 cells. In addition, to evaluate t...
ORGANISM(S): Homo sapiens 
2024-01-01 | GSE240942 | GEO
GenomicsHigh-throughput sequencing in HNRNPD knock-out and knock-in HEK293T cell lines
High-throughput sequencing in HNRNPD knock-out and knock-in HEK293T cell lines
PRJNA877215 | ENA
TranscriptomicsHigh-throughput sequencing in HNRNPD knock-out and knock-in HEK293T cell lines
As HNRNPD regulates the alternative splicing of hundreds of genes, we sought to investigate whether HNRNPD could regulate the biogenesis of circRNAs. To identify the effect of HNRNPD on circRNAs and linear RNAs, we performed circRNA and linear RNAs (ployA enrichment RNA and lncRNA) sequencing in HNR...
ORGANISM(S): Homo sapiens 
2023-09-30 | GSE212767 | GEO
UnknownAuf1/Hnrnpd-deficient mice develop pruritic inflammatory skin disease.
Not available
S-EPMC4074411 | biostudies-literature
UnknownNFκB (RelA) mediates transactivation of hnRNPD in oral cancer cells.
Not available
S-EPMC8993925 | biostudies-literature
UnknownRNA-binding protein HNRNPD promotes chondrocyte senescence and osteoarthritis progression through upregulating FOXM1.
Not available
S-EPMC11668876 | biostudies-literature
UnknownHNRNPD regulates the biogenesis of circRNAs and the ratio of mRNAs to circRNAs for a set of genes.
Not available
S-EPMC11346550 | biostudies-literature
UnknownDepletion of the RNA binding protein HNRNPD impairs homologous recombination by inhibiting DNA-end resection and inducing R-loop accumulation.
Not available
S-EPMC6486545 | biostudies-literature
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