Transcriptomics

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High-throughput sequencing in HNRNPD knock-out SW839 cell lines


ABSTRACT: As HNRNPD regulates the alternative splicing of hundreds of genes, we sought to investigate whether HNRNPD could regulate the biogenesis of circRNAs. To identify the effect of HNRNPD on circRNAs, we performed circRNA sequencing in HNRNPD knockout and wild-type SW839 cells. In addition, to evaluate the impacts of HNRNPD deficiency on circRNA formation, we captured nascent RNA in SW839 and HNRNPD knock-out SW839 cells by immunoprecipitation of 5-ethyluridine (EU) labeling. Comparative analysis of these data, we found the higher expression level of circRNAs in HNRNPD KO SW839 cells.The HNRNPD could influence the circRNA biogenesis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE240942 | GEO | 2024/01/01

REPOSITORIES: GEO

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