Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity

ABSTRACT: Circular RNAs (circRNAs), formed by the atypical head-to-tail splicing of exons, have re-emerged as a potentially interesting RNA species given recent reports of a surprising diversity and abundance of circRNA in organisms ranging from worm to human. Here, using deep RNA sequencing, we profiled different RNA species in mouse and observed that circRNAs are significantly enriched in neural tissue, relative to other tissues. Using PacBio sequencing, we determined, for the first time, the circular structure of this population of circRNAs as well as their full-length sequences. We discovered that a disproportionate fraction of the brain circRNA population is derived from host genes that code for synaptic proteins. Moreover, based on the separate profiling of the RNAs localized in neuronal cell

ORGANISM(S): Mus musculus

SUBMITTER: Xintian YOU 

PROVIDER: E-GEOD-61991 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress