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ProteomicsProteomic characterization of Hsp78-interacting proteins highlights chaperone role during protein aggregation in mitochondria under heat stress - Part B Aggregation
Chaperones of the Hsp100 chaperone family support protein homeostasis, the maintenance of protein activity under stress, by refolding aggregated proteins or targeting them for degradation. Hsp78, the ClpB-type mitochondrial member of the Hsp100 family, can be found in lower eukaryotes like yeast. Al...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-09-20 | PXD030436 | Pride
Hsp78 Yeast Cell biology Mitochondria Chaperone Protein aggregation Proteostasis Heat stress 
ProteomicsProteomic characterization of Hsp78-interacting proteins highlights chaperone role during protein aggregation in mitochondria under heat stress - Part A Protein Interactions
Chaperones of the Hsp100 chaperone family support protein homeostasis, the maintenance of protein activity under stress, by refolding aggregated proteins or targeting them for degradation. Hsp78, the ClpB-type mitochondrial member of the Hsp100 family, can be found in lower eukaryotes like yeast. Al...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-09-20 | PXD030405 | Pride
Yeast  cell biology  mitochondria  heat stress  protein aggregation  proteostasis  chaperone  hsp78 
ProteomicsDistinct types of intramitochondrial protein aggregates protect mitochondria against proteotoxic stress - Data Set1: HSP78 AP-MS
Mitochondria consist of hundreds of proteins, most of which are long-lived and inaccessible to the proteasomal quality control system of the cytosol. How cells stabilize the mitochondrial proteome during challenging conditions is poorly understood. Here we show that mitochondria form spatially defin...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-03-26 | PXD045196 | Pride
Hsp78 aggregates mitochondria 
UnknownElucidation of the interaction proteome of mitochondrial chaperone Hsp78 highlights its role in protein aggregation during heat stress.
Not available
S-EPMC9574514 | biostudies-literature
UnknownHsp78 (78 kDa Heat Shock Protein), a Representative AAA Family Member Found in the Mitochondrial Matrix of Saccharomyces cerevisiae.
Not available
S-EPMC5572323 | biostudies-literature
UnknownA chemical inhibitor of heat shock protein 78 (HSP78) from <i>Leishmania donovani</i> represents a potential antileishmanial drug candidate.
Not available
S-EPMC7380179 | biostudies-literature
ProteomicsDistinct types of intramitochondrial protein aggregates protect mitochondria against proteotoxic stress - Data Set2: PIM1 AP-MS
Mitochondria consist of hundreds of proteins, most of which are long-lived and inaccessible to the proteasomal quality control system of the cytosol. How cells stabilize the mitochondrial proteome during challenging conditions is poorly understood. Here we show that mitochondria form spatially defin...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-03-26 | PXD045286 | Pride
Hsp78 aggregates mitochondria 
UnknownMetabolic and chaperone gene loss marks the origin of animals: evidence for Hsp104 and Hsp78 chaperones sharing mitochondrial enzymes as clients.
Not available
S-EPMC4339202 | biostudies-literature
ProteomicsDistinct types of intramitochondrial protein aggregates protect mitochondria against proteotoxic stress - Data Set3: VAR1 AP-MS
Mitochondria consist of hundreds of proteins, most of which are long-lived and inaccessible to the proteasomal quality control system of the cytosol. How cells stabilize the mitochondrial proteome during challenging conditions is poorly understood. Here we show that mitochondria form spatially defin...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-03-26 | PXD045288 | Pride
Yeast mitochondria aggregates 
ProteomicsDistinct types of intramitochondrial protein aggregates protect mitochondria against proteotoxic stress - Data Set4: Total proteome of NTS-VAR1 expressing yeast cells
Mitochondria consist of hundreds of proteins, most of which are long-lived and inaccessible to the proteasomal quality control system of the cytosol. How cells stabilize the mitochondrial proteome during challenging conditions is poorly understood. Here we show that mitochondria form spatially defin...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-03-26 | PXD045290 | Pride
Yeast mitochondria aggregates 
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