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MetabolomicsA microfluidic chip recapitulating the human neurovascular unit with a functional blood-brain barrier for modeling gut-brain interactions

The blood-brain barrier (BBB) is essential for central nervous system homeostasis, but most current in vitro models lack structural and functional fidelity. We developed a physiologically relevant human neurovascular unit microfluidic chip (hNVU-on-a-chip) incorporating brain microvascular endoth...

2025-10-28 | MTBLS13230 | MetaboLights
ProteomicsBrain microvascular endothelial cells: INSR KD
The insulin receptor (INSR) mediates insulin signaling to modulate cellular functions. Although INSR is expressed at the blood-brain barrier (BBB), its role in the modulation of BBB function is poorly understood. Therefore, in this study, we aimed to analyze the effect of INSR knockdown on the expre...
ORGANISM(S): Homo Sapiens (human) 
2021-12-25 | PXD027326 | JPOST Repository
TranscriptomicsCytotoxic and anti-Toxoplasma gondii activities of monensin on human brain microvascular endothelial cells
The aim of the present work was to investigate the effect of monensin on the in vitro growth of T. gondii tachyzoites and on the host cells (human brain microvascular endothelial cells - hBMECs). The hypotheses were that (1) inhibition of the WNT signalling pathway by monensin can reduce the growth ...
ORGANISM(S): Homo sapiens 
2020-07-06 | E-MTAB-8817 | biostudies-arrayexpress
TranscriptomicsmiRNA analysis of HBMVECs exposed or unexposed to U87 glioma cells
A key step in angiogenesis is the upregulation of growth factor receptors on endothelial cells. Here we demonstrate that a small regulatory microRNA, miR-296 has a major role in this process. Glioma cells and angiogenic growth factors elevate the level of miR-296 in primary human brain microvascular...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-13091 | biostudies-arrayexpress
ProteomicsBrain microvascular endothelial cells: PODXL KD
The purpose of the present study was, therefore, to explore the effect of PODXL-knockdown on the protein expression and transport function in the immortalized human BMECs (hCMEC/D3) as a human BBB model. We established PODXL-knockdown hCMEC/D3 cells, and protein expressions were comprehensively anal...
ORGANISM(S): Homo Sapiens (human) 
2022-03-11 | PXD030652 | JPOST Repository
TranscriptomicsRNA sequencing of human iPSC-derived brain microvascular endothelial cells.
Induced pluripotent stem cells were differentiated to brain microvascular endothelial cells (BMECs) using previously published protocols with minor changes. RNA was collected from purified BMECs after barrier induction and submitted for sequencing.
ORGANISM(S): Homo sapiens 
2020-12-31 | E-MTAB-8802 | biostudies-arrayexpress
TranscriptomicsComparative genomic profile of human brain microvascular endothelial cells upon TWEAK or TNFα stimulation at 3h, 12h, and 24h
The molecular mechanisms playing a role in TWEAK versus TNFɑ signaling on cerebral microvascular endothelial cells are not well defined. Therefore, we aimed to identify gene expression changes in cultures of human brain microvascular endothelial cells (hCMEC/D3) to address changes initiated by TWEAK...
ORGANISM(S): Homo sapiens 
2022-10-20 | E-MTAB-12222 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of human brain microvascular endothelial cells response to Borrelia burgdorferi and its antigen Erp23 using RNA-seq
Using RNA sequencing to map differentially expressed genes in human brain microvascular endothelial cells challenged with Borrelia burgdorferi or its ligand Erp23.
ORGANISM(S): Homo sapiens 
2019-06-21 | E-MTAB-8053 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of human brain microvascular endothelial cells response to Neisseria meningitidis and its antigen MafA using RNA-seq
Using RNA sequencing to map differentially expressed genes in human brain microvascular endothelial cells challenged with Neisseria meningitidis or its ligand MafA .
ORGANISM(S): Homo sapiens 
2019-06-15 | E-MTAB-8008 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of human brain microvascular endothelial cells response to Streptococcus pneumoniae and its antigen Adhesion lipoprotein using RNA-seq
Using RNA sequencing to map differentially expressed genes in human brain microvascular endothelial cells challenged with Streptococcus pneumoniae or its ligand Adhesion lipoprotein.
ORGANISM(S): Homo sapiens 
2019-06-22 | E-MTAB-8054 | biostudies-arrayexpress
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