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TranscriptomicsDUX4 activates germline genes, retroelements and immune-mediators: Implications for facioscapulohumeral dystrophy
Facioscapulohumeral dystrophy (FSHD) is one of the most common inherited muscular dystrophies. The causative gene remains controversial and the mechanism of pathophysiology unknown. Here we identify genes associated with germline and early stem cell development as targets of the DUX4 transcription f...
ORGANISM(S): Homo sapiens 
2012-01-03 | E-GEOD-33799 | biostudies-arrayexpress
ProteomicsShigella infection is facilitated by interaction of human enteric α-defensin 5 with colonic epithelial receptor P2Y11
Human enteric α-defensin 5 (HD5) acts as a “double-edged sword” in host immunity due to its prominent role in promoting pathogen infections, yet the mechanistic basis of its infection-enhancing operation remains unclarified. Here we show that HD5 induces abundant filopodial extensions in epithelial ...
ORGANISM(S): Homo sapiens (Human) 
2024-12-16 | PXD057832 | Pride
Shigella  human defensin 5  filopodia  p2y11  invasion 
UnknownHuman α-Defensin 51-9 and Human β-Defensin 2 Improve Metabolic Parameters and Gut Barrier Function in Mice Fed a Western-Style Diet.
Not available
S-EPMC10531064 | biostudies-literature
UnknownHuman alpha defensin 5 is a candidate biomarker to delineate inflammatory bowel disease.
Not available
S-EPMC5560519 | biostudies-literature
UnknownHuman Enteric Defensin 5 Promotes Shigella Infection of Macrophages.
Not available
S-EPMC6921650 | biostudies-literature
UnknownHuman Defensin-5 Blocks Ethanol and Colitis-Induced Dysbiosis, Tight Junction Disruption and Inflammation in Mouse Intestine.
Not available
S-EPMC6214960 | biostudies-literature
UnknownPaneth cell dysfunction in radiation injury and radio-mitigation by human α-defensin 5.
Not available
S-EPMC10448521 | biostudies-literature
TranscriptomicsDrosophila Sociality Influences Immune Peptide Load and Apoptosis-induced Tumor Suppression independently of the Antitumor Peptide Defensin
Patient’s social environment might influence cancer outcome. This potentially happens in Drosophila, as we previously reported that the social context influences the growth of intestinal tumors. To uncover the underlying social-induced physiological mechanisms, we performed RNA-seq of isogenized beh...
ORGANISM(S): Drosophila melanogaster 
2026-01-01 | E-MTAB-16147 | biostudies-arrayexpress
UnknownCritical determinants of human α-defensin 5 activity against non-enveloped viruses.
Not available
S-EPMC3397880 | biostudies-literature
UnknownReduction of human defensin 5 affords a high-affinity zinc-chelating peptide.
Not available
S-EPMC3783636 | biostudies-literature
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