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ProteomicsIdentification of RNF187 binding proteins by LC-MS/MS
To explore the regulatory network involving RNF187 binding proteins, immunocoprecipitation (IP) experiments were performed in human spermatogonial stem cells (SSCs) via LC-MS/MS analysis and Label-free quantification.
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD060599 | Pride
Rnf187  immunocoprecipitation  lc-ms/ms  human sscs 
TranscriptomicsTranscription profiling of XX and XY sorted mouse somatic support cells and XX and XY mouse whole gonads to identify potential new mammalian gonadal sex determining genes.
Gonadal sex determining (GSD) genes that initiate fetal ovarian and testicular development and differentiation are expressed in the cells of the urogenital ridge that differentiate as somatic support cells (SSCs), i.e., granulosa cells of the ovary and Sertoli cells of the testis. To identify potent...
ORGANISM(S): Mus musculus 
2007-11-30 | E-GEOD-4928 | biostudies-arrayexpress
UnknownLong-term Culture of Human SSEA-4 Positive Spermatogonial Stem Cells (SSCs).
Not available
S-EPMC3898576 | biostudies-literature
TranscriptomicsDynamics of DNA methylation patterning during in vitro propagation of human spermatogonial stem cells
Autotransplantation of in vitro proliferated spermatogonial stem cells (SSCs) has been advocated as a way to restore fertility in childhood cancer survivors. In this study we determined the effects of cell culture on DNA methylation patterning in human SSCs, to evaluate the safety of future clinical...
ORGANISM(S): Homo sapiens 
2016-02-27 | E-GEOD-72444 | biostudies-arrayexpress
TranscriptomicsFGF2-regulated gene expression in cultured mouse spermatogonial stem cells
Transcriptional profiling of mouse spermatogonial stem cells (SSCs) comparing control untreated SSCs with SSCs with exogenous FGF2 withdrawn and FGFR inhibitor SU5402 supplemented (-F+S). Results provide insight into the mechanisms of FGF2-supported in vitro self-renewal of SSCs. Two-condition exper...
ORGANISM(S): Mus musculus 
2010-08-01 | E-GEOD-21294 | biostudies-arrayexpress
TranscriptomicsDistinct gene expression patterns of ‘multipotent' versus ‘unipotent' single colony-derived strains (SCDSs) of human bone marrow stromal cells (BMSCs)
Dyskeratosis congenita (DC) is an inherited multi-system disorder, characterized by oral leukoplakia, nail dystrophy, and abnormal skin pigmentation, as well as high rates of bone marrow failure, solid tumors, and other medical problems such as osteopenia. DC and telomere biology disorders (collect...
ORGANISM(S): Homo sapiens 
2015-05-11 | E-GEOD-64789 | biostudies-arrayexpress
UnknownResveratrol changes spermatogonial stem cells (SSCs) activity and ameliorates their loss in busulfan-induced infertile mouse.
Not available
S-EPMC5347676 | biostudies-literature
TranscriptomicsEGF and LIF enhanced the spontaneous reprogramming of Spermatogonial Stem Cells into Pluripotent State
Germline stem cells are unipotent stem cells dedicated to differentiate into gemmates throughout of life. However, spontaneous reprogramming of spermatogonial stem cells (SSCs) in long-term culture indicates the acquirement of pluripotency of germ cells affected by microenvironment.epidermal growth ...
ORGANISM(S): Mus musculus 
2024-10-28 | E-MTAB-12342 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of induced multipotent germline stem cells and other pluripotent stem cells
Spermatogonial stem cells (SSCs) have pluripotent potential. However, frequency of pluripotent cell derivation is low and the mechanism of culture-induced reprogramming remains unknown. Here we report that epigenetic instability of germline stem (GS) cells, cultured SSCs, induces pluripotent cell de...
ORGANISM(S): Mus musculus 
2013-10-21 | E-GEOD-43850 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse spermatogonial stem cells (SSCs) reveals PU.1 a pleiotropic regulator expressed in the first embryonic stages with a crucial function in germinal progenitors
In the adult mammalian testis, spermatogenic differentiation starts from a minute population of spermatogonial stem cells (SSCs). SSCs are generated after birth from the fetal gonocytes, themselves derived from the primordial germ cells (PGCs), which are specified during the first days after implant...
ORGANISM(S): Mus musculus 
2008-06-18 | E-GEOD-11631 | biostudies-arrayexpress
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