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ProteomicsDistinct protein signature of hypertension-induced damage in the renal proteome of the two-kidney, one-clip ratmodel
Background: Hypertensive nephrosclerosis is one of the most frequent causes of chronic kidney failure. Proteome analysis potentially improves the pathophysiological understanding and diagnostic precision of this disorder. In the present exploratory study, we investigated experimental nephrosclerosis...
ORGANISM(S): Rattus norvegicus (Rat) 
2019-02-28 | PXD012889 | Pride
Hypertension 2k1c Juxtamedullary cortex Kidney 
TranscriptomicsInteraction between diabetes and hypertension in a rat model of diabetic nephropathy
Fisher male Cyp1a1mRen2 rats were allocated into four groups of four biological replicates each: control; streptozotocin-induced diabetes alone; indole-3-carbinol induced hypertension alone; combined induced diabetes and hypertension.
Kidneys were harvested for microarray analysis.analysis.
ORGANISM(S): Rattus norvegicus 
2011-12-31 | E-MEXP-3165 | biostudies-arrayexpress
GenomicsCalcitriol ameliorates damage in high-salt diet-induced hypertension: evidence of communication with the gut–kidney axis
Calcitriol ameliorates damage in high-salt diet-induced hypertension: evidence of communication with the gut–kidney axis
PRJNA766639 | ENA
ProteomicsL-Lysine treated rats' kidney shotgun proteome
Hypertension and kidney disease, two related, common, and severe disease entities have been repeatedly associated with genomic variants and metabolic alterations of lysine metabolism. Here, we developed a stable isotope labeling strategy compatible with untargeted metabolomics acquisition to investi...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-06-01 | PXD029232 | Pride
Hypertension Rat Kidney L-lysine 
ProteomicsTengdan Capsule Prevents Hypertensive Kidney Damage in SHR by Inhibiting Periostin-mediated Renal Fibrosis
In order to reveal the potential molecular mechanism of TDC in renal protection of rats with essential hypertension, TMT-based quantitative proteomics analysis method was used to conduct quantitative analysis of proteins extracted from kidney of SHR of model and TDC treatment groups after 4 weeks of...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-09-10 | PXD024102 | Pride
Teng dan capsule  hypertension-induced kidney damage  periostin  tgfβ/smad signaling pathway  inflammatory response  human kidney hek293 cells 
GenomicsLongitudinal multi-organ transcriptomic atlas of salt-induced hypertension
Longitudinal multi-organ transcriptomic atlas of salt-induced hypertension
PRJNA1303696 | ENA
TranscriptomicsCalcitriol ameliorates damage in high-salt diet-induced hypertension: evidence of communication with the gut–kidney axis
Several studies have established a link between high-salt diet, inflammation, and hypertension. Vitamin D supplementation has shown anti-inflammatory effects in many diseases; gut microbiota is also associated with a wide variety of cardiovascular diseases, but potential role of vitamin D and gut mi...
ORGANISM(S): Rattus norvegicus 
2021-10-12 | GSE184844 | GEO
TranscriptomicsLongitudinal multi-organ transcriptomic atlas of salt-induced hypertension
Salt-sensitive hypertension is a common form of hypertension characterized by an exaggerated blood pressure response to dietary salt intake. The molecular mechanisms linking salt-induced hypertension to multi-organ damage remain poorly defined. To address this issue, we generated a longitudinal mult...
ORGANISM(S): Rattus norvegicus 
2026-04-11 | GSE305010 | GEO
UnknownDifferential effects of cyclo-oxygenase 1 and 2 inhibition on angiogenesis inhibitor-induced hypertension and kidney damage.
Not available
S-EPMC9093150 | biostudies-literature
TranscriptomicsTranscription profiling of rat fetal kidney samples from offspring of hyperinsulinemic mothers
Inrauterine growth restriction was induced by chronic hyper insulinemia in pregnant rats and differential gene expression was studied using affymetrix rat genome RAE230A.Data was analysed using SAM. Experiment Overall Design: rna was isolated from 5 kidneys of growth restricted fetus and compared wi...
ORGANISM(S): Rattus norvegicus 
2007-11-06 | E-GEOD-3215 | biostudies-arrayexpress
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