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ProteomicsChanges in the serum proteome profile of patients with neuroborreliosis, foresters, and patients after ILADS therapy
Objectives: The aim of study was to evaluate the changes in proteomic profile of human serum induced by the development of tick-borne neuroborreliosis (NB), before/after therapy, patients treated with prolonged multidrug therapy according to ILADS (International Lyme and Associated Diseases Society)...
ORGANISM(S): Homo sapiens (Human) 
2025-01-18 | PXD052529 | Pride
Neuroborreliosis Foresters  ilads  proteome 
OtherCoordinated control of genome-nuclear lamina interactions by Topoisomerase 2B and Lamin B receptor (bTMP-seq)
Lamina-associated domains (LADs) are megabase-sized portions of the genome anchored to the nuclear lamina (NL). Factors controlling the tethering of the genome to the NL have remained elusive. Here, we identified DNA Topoisomerase 2 beta (TOP2B) as a prominent regulator of genome-NL interactions. TO...
ORGANISM(S): Homo sapiens 
2025-09-15 | GSE277502 | GEO
TranscriptomicsCoordinated control of genome-nuclear lamina interactions by Topoisomerase 2B and Lamin B receptor (RNA-Seq)
Lamina-associated domains (LADs) are megabase-sized portions of the genome anchored to the nuclear lamina (NL). Factors controlling the tethering of the genome to the NL have remained elusive. Here, we identified DNA Topoisomerase 2 beta (TOP2B) as a prominent regulator of genome-NL interactions. TO...
ORGANISM(S): Homo sapiens 
2025-09-15 | GSE277501 | GEO
OtherCoordinated control of genome-nuclear lamina interactions by Topoisomerase 2B and Lamin B receptor (pA-DamID)
Lamina-associated domains (LADs) are megabase-sized genomic regions anchored to the nuclear lamina (NL). Factors controlling the interactions of the genome with the NL have largely remained elusive. Here, we identified DNA topoisomerase 2 beta (TOP2B) as a regulator of these interactions. TOP2B bind...
ORGANISM(S): Homo sapiens 
2025-09-15 | GSE277500 | GEO
UnknownEvidence assessments and guideline recommendations in Lyme disease: the clinical management of known tick bites, erythema migrans rashes and persistent disease.
Not available
S-EPMC4196523 | biostudies-literature
OtherBeyond A and B Compartments: how major nuclear locales define nuclear genome organization and function.
Models of nuclear genome organization often propose a binary division into active versus inactive compartments yet typically overlook nuclear bodies. Here we integrated analysis of sequencing and image-based data to compare genome organization in four human cell types relative to three different nuc...
ORGANISM(S): Homo sapiens 
2025-05-14 | GSE296389 | GEO
UnknownCoordinated control of genome-nuclear lamina interactions by topoisomerase 2B and lamin B receptor.
Not available
S-EPMC12464825 | biostudies-literature
UnknownMajor nuclear locales define nuclear genome organization and function beyond A and B compartments.
Not available
S-EPMC12029212 | biostudies-literature
GenomicsCoordinated control of genome-nuclear lamina interactions by Topoisomerase 2B and Lamin B receptor (RNA-Seq)
Coordinated control of genome-nuclear lamina interactions by Topoisomerase 2B and Lamin B receptor (RNA-Seq)
PRJNA1162537 | ENA
GenomicsCoordinated control of genome-nuclear lamina interactions by Topoisomerase 2B and Lamin B receptor (pA-DamID)
Coordinated control of genome-nuclear lamina interactions by Topoisomerase 2B and Lamin B receptor (pA-DamID)
PRJNA1162536 | ENA
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