immune-mediated disease

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Unknown (10969)
Transcriptomics (2410)
Genomics (1475)
Proteomics (315)
Metabolomics (105)
Other (49)
Methylation profiling (21)
Models (18)
Genomic (8)
Multiomics (5)
Clinical (5)

Organisms

Homo sapiens (1335)
Mus musculus (1041)
Rattus norvegicus (62)
Arabidopsis thaliana (55)
Drosophila melanogaster (30)
Bos taurus (28)
Caenorhabditis elegans (19)
Danio rerio (15)
Macaca mulatta (15)
Saccharomyces cerevisiae (11)
Sus scrofa (11)
Oryza sativa (11)
Carassius auratus (8)
Canis lupus familiaris (8)
Streptococcus agalactiae (7)
Salmo salar (7)
Hordeum vulgare (6)
Gallus gallus (6)
Campylobacter jejuni (5)
Solanum lycopersicum (5)
Glycine max (5)
Macaca nemestrina (4)
Scophthalmus maximus (3)
Mycobacterium avium subsp. paratuberculosis (3)
Schmidtea mediterranea (3)
Apis mellifera (3)
Anopheles gambiae (3)
Mycobacterium tuberculosis (3)
Oryza sativa Japonica Group (3)
Mustela putorius furo (2)

Organisms

Mus musculus (480)
Homo sapiens (421)
Arabidopsis thaliana (14)
Rattus norvegicus (12)
Oryza sativa (8)
Canis lupus familiaris (6)
Macaca mulatta (6)
Bos taurus (5)
Sus scrofa (4)
Danio rerio (4)
Salmo salar (3)
mouse gut metagenome (3)
Plasmodium falciparum (2)
Staphylococcus aureus (2)
Mesocricetus auratus (2)
Macaca fascicularis (2)
human metagenome (2)
Scophthalmus maximus (2)
Gallus gallus (2)
Glycine max (2)
human gut metagenome (2)
Cronobacter turicensis (1)
Enterovirus A71 (1)
Salmonella enterica subsp. enterica serovar Typhi (1)
Candida albicans (1)
Campylobacter jejuni (1)
Cryptococcus neoformans (1)
Streptococcus pneumoniae (1)
Mycobacterium tuberculosis (1)
Clostridioides difficile (1)

Repository

biostudies-arrayexpress (1681)
ENA (1247)
geo (926)
pride (141)
EGA (118)
MetaboLights (104)
MassIVE (94)
iProX (40)
BioModels (16)
jPOST (15)
PanoramaPublic (9)
dbGaP (8)
Cell Collective (2)
GPMDB (2)
EVA (1)
GNPS (1)

Tissue

Cell culture (25)
Epithelial cell (15)
Macrophage (14)
T cell (14)
Blood (12)
Brain (8)
Liver (6)
JURKAT cell (5)
Plant cell (5)
Hepatocyte (5)
B cell (5)
Blood serum (4)
Blood plasma (4)
Kidney (4)
Bone marrow (3)
Fibroblast (3)
Primary cell (3)
Glomerular cell (2)
T-lymphocyte cell line (2)
Renal glomerulus (2)
Peripheral blood mononuclear cell (2)
Microglial cell (2)
Skin (2)
Leukocyte (2)
Feces (2)
Heart (2)
Dendritic cell (2)
Spleen (2)
Leaf (2)
Lung (2)

Disease

Crohn's disease (8)
Inflammatory bowel disease (3)
Normal (3)
Alzheimer's disease (2)
Asthma (2)
Rheumatoid arthritis (2)
Tumor bearing (1)
Aviremic HIV (1)
Active ITP (1)
Polycystic Lipomembranous Osteodysplasia with Sclerosing Leukoencephalopathy (1)
SMARD1 (1)
Insulitis and diabetes (1)
Primary effusion lymphoma (PEL) (1)
LPS-induced acute lung injury (1)
Aggressive insulitis (1)
Psoriasis vulgaris (1)
Liver cancer (1)
Sham infected (1)
Burkitt's lymphoma (1)
Mild hyperglycemia, liver dysfunction, and renal glycosuria (1)
Sjogren's syndrome (1)
Immuno-osseus dysplasiaspondyloenchondrodysplasia (SPENCD) (1)
Apparently healthy (1)
AIDS-KS, HIV+, nodular (late) stage (1)
Controled disease patient (1)
Chronic infection with geohelminth ascaris lumbricoides (1)
Mesothelioma (1)
Lung large cell carcinoma (1)
IRAK-4 Q293X mutation (1)
Gestational diabetes mellitus (1)

Technology Type

Mass Spectrometry (141)
Shotgun proteomics (73)
Mass spectrometry (66)
Bottom-up proteomics (35)
Mass spectrometry assay (27)
Data-independent acquisition (17)
Data-dependent acquisition (16)
NMR spectroscopy (8)
Gel-based experiment (8)
Top-down proteomics (6)
Affinity purification coupled with mass spectrometry proteomics (6)
Affymetrix 500K, unknown (3)
NMR spectroscopy assay (3)
SWATH MS (3)
ILLUMINA, Illumina HiSeq 2500 (2)
Illumina HiSeq 2000 (2)
All-ion fragmentation (2)
Illumina HiSeq 4000, Illumina HiSeq4000, ILLUMINA (1)
Illumina 450K, Bisulfite-Seq (1)
Illumina Infinium HumanMethylation450 BeadChips (1)
Unknown, Affymetrix 500K (1)
Illumina Genome Analyzer II (1)
MSE (1)
DiaPASEF (1)

Instrument Platform

Illumina NovaSeq 6000 (40)
Illumina HiSeq 2500 (28)
NextSeq 500 (22)
Illumina HiSeq 2000 (21)
Illumina HiSeq 4000 (16)
Agilent High resolution C scanner (4)
Illumina MiSeq (4)
NextSeq 550 (4)
Illumina HiSeq 3000 (4)
NextSeq 2000 (3)
Illumina HiSeq 1000 (3)
Illumina HiSeq 1500 (3)
Not applicable (2)
Bioanalyser (2)
Illumina NovaSeq X (2)
- (2)
N/A (2)
DNBSEQ-T7 (2)
Illumina HiSeq 2000 platform (1)
N/C (1)
10X Genomics Single Cell, V3.1 (1)
Performed by Novogene; Illumina library preparation instrumentation (provider standard) (1)
Chromatin IP kit (1)
Immunomagnetic separation system (e.g., Miltenyi MACS separator), Tissue culture facilities (biosafety cabinet, CO₂ incubator) , Bench centrifuge (1)
FastPrep-24 5G bead beater, Qubit Fluorometer (1)
12 well TC-treated plate, LETs buffer, dry ice (1)
Affymetrix GeneTitan™ System (1)
Affymetrix GeneTitan™ Instrument (1)
Affymetrix WT PLUS Reagent Kit (1)
Genolab M (1)

Publication Date

2025 (273)
2026 (247)
2014 (230)
2013 (227)
2024 (209)
2010 (209)
2012 (200)
2015 (170)
2011 (162)
2023 (129)
2016 (120)
2008 (120)
2022 (117)
2021 (107)
2020 (102)
2009 (94)
2019 (74)
2018 (70)
2017 (51)
2007 (51)
2005 (21)
2006 (12)
2004 (5)
2003 (1)

UNIPROT ID/AC

P05231 (5)
P02741 (4)
P08887 (4)
C4NUM1 (1)
A2RSY7 (1)
Q9ES17 (1)
Q9HBE4 (1)
P01579 (1)
P22301 (1)
P05112 (1)
P01375 (1)
P61812 (1)
P60568 (1)

CHEBI ID

CHEBI:16737 (15)
CHEBI:16919 (15)
CHEBI:15428 (14)
CHEBI:17368 (13)
CHEBI:30769 (13)
CHEBI:17568 (12)
CHEBI:16414 (12)
CHEBI:15354 (12)
CHEBI:27266 (11)
CHEBI:15741 (11)
CHEBI:17203 (11)
CHEBI:37084 (10)
CHEBI:24898 (10)
CHEBI:16449 (10)
CHEBI:28044 (10)
CHEBI:18183 (10)
CHEBI:16704 (10)
CHEBI:16857 (10)
CHEBI:18050 (10)
CHEBI:16467 (10)
CHEBI:17895 (10)
CHEBI:17596 (10)
CHEBI:28842 (10)
CHEBI:1148 (9)
CHEBI:15366 (9)
CHEBI:16870 (9)
CHEBI:78320 (9)
CHEBI:32816 (9)
CHEBI:18012 (9)
CHEBI:52217 (2)

Metabolite Name

Choline (18)
Creatinine (18)
Hypoxanthine (18)
Adenine (18)
Taurine (17)
Creatine (17)
L-Proline (16)
L-Phenylalanine (16)
L-Histidine (15)
Xanthine (15)
Uracil (14)
L-Tyrosine (14)
Adenosine (14)
L-Valine (13)
Inosine (13)
Uridine (13)
L-Alanine (12)
Glycine (12)
L-Tryptophan (12)
Guanosine (12)
Valine (11)
Guanine (11)
Betaine (11)
L-Lysine (11)
L-Arginine (11)
L-Threonine (11)
L-Methionine (11)
Phenylalanine (11)
L-Glutamine (11)
Caffeine (11)

First Public Date

2025 (242)
2026 (221)
2024 (201)
2023 (109)
2014 (89)
2021 (82)
2022 (78)
2020 (74)
2019 (52)
2018 (37)
2017 (29)
2016 (15)
2015 (11)
2013 (6)
2012 (1)

Modelling Approach

Ordinary differential equation model (12)
Constraint-based model (4)

Study status

Not provided (2)
Completed (2)
Recruiting (1)

Lab affiliation

Department of Fundamental Neurosciences, Rue du Bugnon 9, 1005, Lausanne (3)
Centre for Ocular Regeneration (CORE), Prof. Brien Holden Eye Research Centre (BHERC), L V Prasad Eye Institute, Hyderabad, Telangana, India (2)
State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou 510060, China (2)
First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China (2)
III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (2)
Immunology Research Center, National Health Research Institutes, Zhunan, Taiwan. (2)
State Key Laboratory of Oncology in South China (2)
Principal Investigator | The Ernst and Kaethe Ascher Career Development Chair | The Department of Immunology and Regenerative Biology | Weizmann-UK Building, Room 17 | Weizmann Institute of Science | Rehovot 76100, ISRAEL | Tel: +972-8-934-4937 (1)
Associate Professor of Medicine: Rheumatology Chair, Gene Therapy and Vaccines Graduate Program Director, RVCL Research Center University of Pennsylvania Perelman School of Medicine (1)
PI The Wistar Institute, Philadelphia, PA, USA; (1)
Experimental Systems Immunology, Max Planck Institute of Biochemistry, Martinsried, Germany. (1)
Department of Pediatric Hematology, Immunology & Infectious Disease, Emma Children’s Hospital, Academic Medical Center (AMC), University of Amsterdam, Amsterdam, The Netherlands (1)
Technical University of Denmark (lab head) (1)
Department of Chemistry, University of California, Riverside, CA 92502, USA (1)
Mayo Clinic, Rochester, MN (1)
Laboratory of Experimental Hematology, Vaccine and Infectious Disease Institute (Vaxinfectio), University of Antwerp, 2610 Wilrijk, Belgium (1)
Institute of Bioinformatics, International Technology Park, Bangalore 560066 (1)
MRC Centre for Drug Safety Science, Dept Molecular and Clinical Pharmacology, University of Liverpool (1)
State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian, China. (1)
Institute for Research in Biomedicine (IRB), Barcelona Institute of Science and Technology (BIST), Barcelona 08028, Spain; Catalan Institution for Research and Advanced Studies (ICREA), Barcelona 08010, Spain (1)
Department of Fundamental Neurosciences University of Lausanne Rue du Bugnon 9 1005 Lausanne (1)
Unité d’Immunobiologie de l’Infection, Institut Pasteur, Paris, France (1)
Aalborg University, Denmark (1)
Department of Molecular Pathology and Biology, Faculty of Military Health Sciences (1)
State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, PR China (1)
The Provincial Key Lab of Plant Pathology of Hubei Province, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, 430070, China (1)
The First Affiliated Hospital of Southern University of Science and Technology, the Second Clinical Medical College of Jinan University, Shenzhen People’s Hospital, Shenzhen 518020, China (1)
Department of Laboratory Medicine and Advanced Biotechnologies, Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (IRCCS - ISMETT) Via Ernesto Tricomi, 5 - 90127 Palermo (1)
Laboratory of Immunology, Division of Biotechnology Review and Research III, Office of Biotechnology Products,Center for Drugs Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA (1)
Radiation Oncology Department Weill Cornell Medicine College 1300 York Avenue, NY, NY 10065 (1)

Keyword

Pfizer SARS-CoV-2 Vaccine BNT162b2, Moderna SARS-CoV-2 Vaccine, Novavax COVID-19 Vaccine NVX-CoV2373 (1)
Oncolytic Vaccinia Virus (1)
Tumor Cell Death (1)
Viral Therapy (1)
Anti-Tumor Immunity (1)
Tremelimumab (1)
Atezolizumab (1)
Durvalumab (1)
Antibodies (1)

IsPrivate

False (16)

Submitter Keywords

FROG (4)
Immuno-oncology (3)

Classification

bacteria (8)
fungi (2)
protozoa (2)
viruses (1)

Modification

4-tetrahydrothiazine-3-carboxylic acid (1)

Study type

Transcription profiling by array (1203)
RNA-seq of coding RNA (169)
ChIP-seq (34)
RNA-seq of non coding RNA (32)
RNA-seq of coding RNA from single cells (31)
Unknown experiment type (29)
ChIP-chip by tiling array (23)
Methylation profiling by array (23)
Transcription profiling by RT-PCR (21)
Other (18)
Proteomic profiling by array (10)
RNA-seq of total RNA (9)
ChIP-chip by array (8)
Comparative genomic hybridization by array (7)
MicroRNA profiling by array (7)
Animal - One-color microarray (6)
Animal - High-throughput sequencing (6)
MicroRNA profiling by high throughput sequencing (5)
RNAi profiling by array (4)
Human - Single-cell sequencing (3)
Cell line - High-throughput sequencing (3)
Bisulfite-seq (3)
Methylation profiling by high throughput sequencing (3)
Transcription profiling by SAGE (2)
ATAC-seq (2)
Single nucleus RNA sequencing (2)
DNA-seq (2)
Cell line - Single-cell sequencing (1)
Human - Methylation microarray (1)
Animal - Single-cell sequencing (1)

Release Date

2022 (1421)
2025 (1398)
2023 (1246)
2021 (1219)
2024 (1010)
2020 (890)
2019 (646)
2018 (605)
2015 (532)
2016 (528)
2014 (493)
2017 (492)
2013 (419)
2012 (374)
2010 (309)
2011 (297)
2026 (236)
2008 (171)
2009 (157)
2007 (92)
2005 (35)
2006 (32)
2004 (16)
2002 (9)
2000 (6)
2003 (5)
2001 (4)
1998 (4)
1999 (2)
1997 (1)

Location

France (2)
Spain (1)
United States (1)
United Kingdom (1)
Switzerland (1)

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Enterobacter ludwigii protects DSS-induced colitis through choline-mediated immune tolerance

Commensal intestinal bacteria play key roles in regulating cells mediating immune tolerance; however, bacterial strains and related metabolites directly involved in this regulation are largely unknown. Here, using a mouse model of dextran sulfate sodium (DSS)-induced colitis combined with different ...

2024-08-05 | MTBLS5585 | MetaboLights

Biochemical Profiling of the Brain and Blood Metabolome in a Mouse Model of Prodromal Parkinson’s Disease Reveals Distinct Metabolic Profiles (NMR assay)

Parkinson’s disease is the second most common neurodegenerative disease. In the vast majority of cases the origin is not genetic and the cause is not well understood, although progressive accumulation of α-synuclein aggregates appears central to the pathogenesis. Currently, treatments that slow dise...

2019-02-07 | MTBLS640 | MetaboLights

Integrative Metabolomics-GWAS Mendelian Randomization Reveals Causal Metabolic and Inflammatory Drivers of Parkinson's Disease

Parkinson's disease (PD) is the second most common neurodegenerative disorder, characterized by a complex pathogenesis involving the interplay of multiple molecular and cellular pathways. In recent years, metabolic dysregulation and neuroinflammation have been recognized as key contributors to PD...

2025-11-05 | MTBLS13269 | MetaboLights

Bach2 represses effector programmes to stabilize Treg-mediated immune homeostasis

Through their functional diversification, CD4+ T cells play key roles in both driving and constraining immune-mediated pathology. Transcription factors are critical in the generation and maintenance of cellular diversity and negative regulators antagonistic to alternate fates often act in conjunctio...

ORGANISM(S): Mus musculus

2013-06-27 | E-GEOD-45975 | biostudies-arrayexpress

Persistent Alterations in Plasma Lipid Profiles Before Introduction of Gluten in the Diet Associated With Progression to Celiac Disease

OBJECTIVES: Celiac disease (CD) is a chronic enteropathy characterized by an autoimmune reaction in the small intestine of genetically susceptible individuals. The underlying causes of autoimmune reaction and its effect on host metabolism remain largely unknown. Herein, we apply ...

2020-01-22 | MTBLS729 | MetaboLights

Biochemical Profiling of the Brain and Blood Metabolome in a Mouse Model of Prodromal Parkinson’s Disease Reveals Distinct Metabolic Profiles (MS assays)

2019-02-07 | MTBLS674 | MetaboLights

Immune Mediated Disorders after Allo-HCG

Allogeneic hematopoietic cell transplantation (HCT) is the only known curative option for many hematologic disorders. After transplantation, many patients develop immune mediated disorders that may be life-threatening. Post-HCT immune mediated disorders are rare relative to other diseases but the...

phs001331 | dbGaP

Dwivedi2014 - Crohns IL6 Disease model - sgp130 activity

Dwivedi2014 - Crohns IL6 Disease model - sgp130 activity This model is comprised of four models: [BIOMD0000000534] Healthy Volunteer model [BIOMD0000000535] Crohn's Disease - IL-6 Antibody [BIOMD0000000536] Crohn's Disease - sgp130FC [BIOMD0000000537] Crohn's Dise...

2024-09-02 | BIOMD0000000536 | BioModels

Dwivedi2014 - Crohns IL6 Disease model - Anti-IL6 Antibody

Dwivedi2014 - Crohns IL6 Disease model - Anti-IL6 Antibody This model is comprised of four models: [BIOMD0000000534] Healthy Volunteer model [BIOMD0000000535] Crohn's Disease - IL-6 Antibody [BIOMD0000000536] Crohn's Disease - sgp130FC [BIOMD0000000537] Crohn's Di...

2024-09-02 | BIOMD0000000535 | BioModels

Dwivedi2014 - Crohns IL6 Disease model - Anti-IL6R Antibody

Dwivedi2014 - Crohns IL6 Disease model - Anti-IL6R Antibody This model is comprised of four models: [BIOMD0000000534] Healthy Volunteer model [BIOMD0000000535] Crohn's Disease - IL-6 Antibody [BIOMD0000000536] Crohn's Disease - sgp130FC [BIOMD0000000537] Crohn's D...

2024-09-02 | BIOMD0000000537 | BioModels

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