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GenomicsRNA-seq on MHV68 infected GC B cells expressing distinct immunoglobulin light chains
RNA-seq on MHV68 infected GC B cells expressing distinct immunoglobulin light chains
PRJNA588096 | ENA
ProteomicsHelical superstructures between amyloid and collagen VI in heart derived fibrils from a patient with Light Chain Amyloidosis
we investigated the N-glycosylation of the amyloid fibrils extracted from the heart of a patient affected by AL amyloidosis, using a proteomic approach to evaluate indirectly the presence of glycans in immunoglobulin light chains.
ORGANISM(S): Homo sapiens (Human) 
2024-07-02 | PXD049369 | Pride
Immunoglobulin light chains  n-glycosylation  amyloid fibrils 
ProteomicsDe novo sequencing of antibody light chain proteoforms from patients with multiple myeloma
In multiple myeloma diseases, monoclonal immunoglobulin light chains (LCs) are abundantly produced, with as a consequence in some cases the formation of deposits affecting various organs, such as kidney, while in other cases to remain soluble up to concentrations of several g.L-1 in plasma. The exac...
ORGANISM(S): Homo sapiens (Human) 
2021-08-11 | PXD025884 | Pride
Proteoforms Top-down proteomics Antibody Bottom-up proteomics De novo sequencing Light chain disease 
ProteomicsConformational differences in the light chain constant domain of immunoglobulin G and free light chain may influence proteolysis in AL amyloidosis
Immunoglobulin light chain amyloidosis (AL) is a life-threatening disease caused by the deposition of monoclonal light chain (LC) and its fragments containing variable (VL) and portions of constant (CL) domains. AL patients feature either monoclonal free LCs circulating as covalent and noncovalent h...
ORGANISM(S): Homo sapiens (Human) 
2025-12-08 | PXD055570 | Pride
Igg  amyloid light chain hdx-ms  al amyloidosis  hydrogen/deuterium exchange mass spectrometry 
TranscriptomicsRNA-seq on MHV68 infected GC B cells expressing distinct immunoglobulin light chains
We performed RNA-seq to examine the differences in GC B cells that were either infected with MHV68 or uninfected and between B cells that expressed IgL or IgK B cell receptor light chains.
ORGANISM(S): Mus musculus 
2020-03-02 | GSE140056 | GEO
ProteomicsRole of Complementarity-Determining Regions 1 and 3 in Pathologic Amyloid Formation by Human Immunoglobulin κ1 Light Chains
Immunoglobulin light chain (LC) amyloidosis is a life-threatening disease whose understanding and treatment is complicated by vast numbers of patient-specific mutations. To address molecular origins of the disease, we explored 14 patient-derived and engineered proteins related to κ1-family germline ...
ORGANISM(S): Homo sapiens (Human) 
2023-05-23 | PXD039682 | Pride
Light chain amyloidosis  misfolded states  protein stability  protein dynamics  hdx ms  hydrogen deuterium exchange mass spectrometry 
ProteomicsDe novo sequencing of monoclonal immunoglobulin light chains associated with LCPT
This project provides high-resolution LC-MS/MS datasets dedicated to the de novo sequencing of monoclonal immunoglobulin light chains (FLCs) associated with light chain proximal tubulopathy (LCPT). LCPT is a rare renal manifestation of plasma cell dyscrasias, characterized by proximal tubule dysfunc...
ORGANISM(S): Homo Sapiens 
PXD076770 |
ProteomicsNext-generation Serology by Mass Spectrometry:Readout of the SARS-CoV-2 Antibody Repertoire
Methods of antibody detection are used to assess exposure or immunity to a pathogen. Here, we present Ig-MS, a novel serological readout that captures the immunoglobulin (Ig) repertoire at molecular resolution, including entire variable regions in Ig light and heavy chains. Ig-MS uses new advances i...
ORGANISM(S): Homo Sapiens 
2022-09-24 | PXD028627 | panorama
UnknownCytotoxicity of amyloidogenic immunoglobulin light chains in cell culture.
Not available
S-EPMC3032327 | biostudies-literature
GenomicsRNA-based full length immunoglobulin light chain sequencing reveals lambda constant domain mutations with potential implications for thermodynamic stability in light chain amyloidosis
RNA-based full length immunoglobulin light chain sequencing
PRJEB109785 | ENA
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