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MetabolomicsRA-MAP: mapping the molecular immunological landscape in early rheumatoid arthritis with vaccine controls

Rheumatoid arthritis (RA) is a chronic inflammatory disorder with poorly defined aetiology characterised by synovial inflammation with variable disease severity and drug responsiveness. To investigate the peripheral blood immune cell landscape of RA, we performed comprehensive clinical and molecu...

2021-06-16 | MTBLS1497 | MetaboLights
MetabolomicsRegional Immunological and Microbial Characterization of Peyer's Patches in the Small Intestine of Bactrian Camels

Background: Our earlier research showed that Bactrian camels have a unique lymph aggregation structure that is similar to ileal Peyer's patches (PPs) and plays a role in the mucosal immunology of the digestive tract. However, Bactrian camels exhibit PPs not only in the ileum but also in all segme...

2024-11-11 | MTBLS10376 | MetaboLights
TranscriptomicsATF7 mediates lipopolysaccharide-induced epigenetic changes in macrophages involved in innate immunological memory (expression)
Immunological memory is generally thought to be mediated exclusively by lymphocytes such as memory T and B cells. However, enhanced innate immune responses caused by a previous infection increase protection against reinfection suggesting the presence of innate immunological memory. Here, we describe...
ORGANISM(S): Mus musculus 
2015-08-31 | E-GEOD-71111 | biostudies-arrayexpress
TranscriptomicsATF7 mediates lipopolysaccharide-induced epigenetic changes in macrophages involved in innate immunological memory (ChIP)
Immunological memory is generally thought to be mediated exclusively by lymphocytes such as memory T and B cells. However, enhanced innate immune responses caused by a previous infection increase protection against reinfection suggesting the presence of innate immunological memory. Here, we describe...
ORGANISM(S): Mus musculus 
2015-08-31 | E-GEOD-71112 | biostudies-arrayexpress
MetabolomicsFetal Metabolic Stress Disrupts Immune Homeostasis and Induces Proinflammatory Responses in Human Immunodeficiency Virus Type 1- and Combination Antiretroviral Therapy-Exposed Infants
Increased morbidity and fetal growth restriction are reported in uninfected children born to human immunodeficiency virus type 1 (HIV-1)–infected women treated with antiretroviral (ARV) therapy. Viruses and/or pharmacological interventions such as ARVs can induce metabolic stress, skewing the cell’s...
2018-06-06 | MTBLS449 | MetaboLights
TranscriptomicsImmunological Genome Project data Phase 1
Gene-expression microarray datasets generated as part of the Immunological Genome Project (ImmGen). Primary cells from multiple immune lineages are isolated ex-vivo, primarily from young adult B6 male mice, and double-sorted to >99% purity. RNA is extracted from cells in a centralized manner, amplif...
ORGANISM(S): Mus musculus 
2009-05-02 | E-GEOD-15907 | biostudies-arrayexpress
MetabolomicsB cell expression of the enzyme PexRAP, an intermediary in ether lipid biosynthesis, promotes antibody responses and germinal center size.

The qualities of antibody (Ab) responses provided by B lymphocytes and their plasma cell (PC) descendants are crucial facets of responses to vaccines and microbes. Metabolic processes and products regulate aspects of B cell proliferation and differentiation into germinal center (GC) and PC states...

2026-04-13 | MTBLS13880 | MetaboLights
ModelsWodarz2003 - Immunological Memory
This a model from the article: Evolution of immunological memory and the regulation of competition between pathogens. Wodarz D. Curr Biol 2003 Sep 16;13(18):1648-52 13678598 , Abstract: Memory is a centra...
2024-09-02 | BIOMD0000000684 | BioModels
TranscriptomicsATF7 mediates lipopolysaccharide-induced epigenetic changes in macrophages involved in innate immunological memory
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2015-08-31 | E-GEOD-71113 | biostudies-arrayexpress
ModelsCreemers2021 - Tumor-immune dynamics and implications on immunotherapy responses
This ordinary differential equation model simulating the mechanisms that govern cancer-immune dynamics and their role in tumor responses to immunotherapy is described by the publication: Creemers JHA, Lesterhuis WJ, Mehra N, et al. "A tipping point in cancer-immune dynamics leads to divergent immuno...
2024-09-02 | BIOMD0000001022 | BioModels
Immuno-oncology 
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