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MetabolomicsStability in metabolic phenotypes and inferred metagenome profiles before the onset of colitis-induced inflammation
Inflammatory bowel disease (IBD) is associated with altered microbiota composition and metabolism, but it is unclear whether these changes precede inflammation or are the result of it since current studies have mainly focused on changes after the onset of disease. We previously showed differences in...
2017-07-14 | MTBLS432 | MetaboLights
MetabolomicsSurvival of the littlest: Navigating sepsis diagnosis beyond inflammation in preterm neonates
Background Sepsis diagnosis in preterm neonates is challenging due to symptom overlap with non-infectious inflammatory conditions, and slow, unreliable diagnostic practices. This study aims to identify metabolic biomarkers to elucidate sepsis pathophysiology, and enable timely, accurate diagnosis, w...
2025-07-07 | MTBLS10665 | MetaboLights
Metabolomics4-Octyl itaconate as a metabolite derivative inhibits inflammation via alkylation of STING

The Krebs cycle-derived metabolite itaconate, whose production is catalyzed by immune response gene 1 (IRG1), has excellent potential to link immunity and metabolism in activated macrophages through alkylation or competitive inhibition of target proteins. In support of this, our previous study de...

2023-01-15 | MTBLS5877 | MetaboLights
MetabolomicsResearch on vaccine immunity based on gut microbiota and metabolomics The impact of pseudorabies virus infection

Pseudorabies virus infection causes intestinal flora disorder in animals, leading to diarrhea. To explore the effect of inactivated pseudorabies vaccine immunization on pseudorabies virus infection, this study sequenced the serum metabolome and intestinal microbiota of Hu sheep, analyzed their di...

2025-09-03 | MTBLS12933 | MetaboLights
MetabolomicsResearch on vaccine immunity based on gut microbiota and metabolomics The impact of pseudorabies virus infection

Pseudorabies virus infection causes intestinal flora disorder in animals, leading to diarrhea. To explore the effect of inactivated pseudorabies vaccine immunization on pseudorabies virus infection, this study sequenced the serum metabolome and intestinal microbiota of Hu sheep, analyzed their di...

2025-09-04 | MTBLS12936 | MetaboLights
MetabolomicsLysosomal Acidity and Cathepsin L Activate Eosinophils via ARG1-Mediated Arginine Metabolism in Allergic Airway Inflammation

Eosinophils are the predominant immune cells implicated in the pathogenesis of asthma, highlighting the need for strategies to mitigate their effects. While previous studies have indicated a potential relationship between lysosomes and eosinophils, the precise role of lysosomes in eosinophil acti...

2025-09-15 | MTBLS13001 | MetaboLights
MetabolomicsSuccinate drives macrophage inflammation by promoting GPR91 mitochondrial signaling in rheumatoid arthritis

Succinate is implicated in rheumatoid arthritis (RA) and other inflammatory diseases via its receptor, G protein-coupled receptor 91 (GPR91). Despite its therapeutic potential, conflicting reports on its inflammatory roles have hindered GPR91-targeted treatm...

2026-02-05 | MTBLS13828 | MetaboLights
MetabolomicsTranscobalamin 2 orchestrates monocyte proliferation and TLR4-driven inflammation in systemic lupus erythematosus via folate one-carbon metabolism

BACKGROUND: SLE is a complex autoimmune disease with deleterious effects on various organs. Accumulating evidence has shown abnormal vitamin B12 and one-carbon flux contribute to immune dysfunction. Transcobalamin II (TCN2) belongs to the vitamin B12-binding protein family respon...

2024-05-28 | MTBLS9136 | MetaboLights
TranscriptomicsHuman keratinocytes have a response to injury that upregulates CCL20 and other genes linking innate and adaptive immunity
In the early stages of wound healing, keratinocytes become “activated” and release inflammatory molecules such as interleukin-1 and interleukin-8 that are linked to innate immune responses and neutrophil recruitment. It is unclear, however, whether keratinocytes release molecules linked to adaptive ...
ORGANISM(S): Homo sapiens 
2011-09-19 | E-GEOD-30355 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis in human kidney to investigate whether fibrosis with inflammation at one year post transplant predicts transplant functional decline
We previously observed reduced graft survival for kidney transplants having interstitial fibrosis with subclinical inflammation, but not fibrosis alone, on 1-year protocol biopsy. The current study aimed to determine whether fibrosis with inflammation at 1 year is associated with renal functional de...
ORGANISM(S): Homo sapiens 
2010-11-01 | E-GEOD-22459 | biostudies-arrayexpress
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