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MetabolomicsMetabolic profilings of rat INS-1 β-cells under changing levels of essential amino acids

Application of mass spectrometry enables the detection of metabolic differences between organisms with different nutritional settings. Divergence in the metabolic fingerprints of rat pancreatic INS-1 β-cells were systematically captured with regard to 10 individual essential amino acid (EAA) avai...

2022-05-24 | MTBLS3963 | MetaboLights
MetabolomicsMetabolomic Profiles of Pancreatic β-Cells and Islets Exposed to Arsenic, part I β-Cells
Not available
ORGANISM(S): Mus musculus 
ST001266 | MetabolomicsWorkbench
MetabolomicsIAPP toxicity activates HIF1α/PFKFB3 signaling delaying β-cell loss at the expense of β-cell function
The islet in type 2 diabetes (T2D) is characterized by amyloid deposits derived from islet amyloid polypeptide (IAPP), a protein co-expressed with insulin by β-cells. In common with amyloidogenic proteins implicated in neurodegeneration, human IAPP (hIAPP) forms membrane permeant toxic oligomers imp...
2020-04-17 | MTBLS951 | MetaboLights
TranscriptomicsTranscription profiling of rat insulinoma-beta (INS-1E) cells exposed to the cytokines IL-1-beta and IFN-gamma for six different lengths of time and with or without the inducible NO synthase blocker NMA
Locally released cytokines contribute to beta cell dysfunction and apoptosis in Type 1 diabetes. In vitro exposure of insulin producing INS-1E cells to the cytokines interleukin (IL)-1beta + interferon (IFN) gamma leads to a significant increase in apoptosis. To characterize the genetic networks im...
ORGANISM(S): Rattus norvegicus 
2006-06-14 | E-CBIL-10 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of clonal INS-1 832/13 beta-cells
This experiment aimed to measure gene expression in glucose-responsive beta-cells. RNA was extracted using RNeasy Mini kit. Quantity and quality of extracted RNA were assessed by the NanoDrop spectrophotometer ND-1000 and Experion RNA StdSens Analysis Kit, respectively. Background correction, normal...
ORGANISM(S): Rattus norvegicus 
2015-01-30 | E-MTAB-3232 | biostudies-arrayexpress
TranscriptomicsDetailed transcriptome atlas of the pancreatic beta cell
The aim of the present study was to explore the transcriptome of pancreatic islets and, based on this information, to prepare a comprehensive and open access inventory of insulin-producing ?-cell gene expression, the beta-Cell Gene Atlas (BCGA). INS-1 cells, primary rat beta-cells (>87% beta-cells) ...
ORGANISM(S): Rattus norvegicus 
2008-12-31 | E-GEOD-13381 | biostudies-arrayexpress
ProteomicsQuantitaQuantitative proteomic analysis of β-cells response to thapsigargin and rotenone uncovers key pathways of rat β-cell dysfunction tive proteomic analysis of β-cells response to thapsigargin and rotenone uncovers key pathways of rat β-cell dysfunction
We designed a TMT peptide labeling-based quantitative proteomics strategy to achieve a high-accuracy analysis of proteomic changes in response to ER stress and mitochondria stress on INS-1 cells under three different culture conditions: control (Cont), rotenone (Rot), and thapsigargin (Tpg), each wi...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-07-20 | PXD030711 | Pride
Endoplasmic reticulum (er) stress  mitochondria stress  quantitative proteomics  tmtpro  ins-1 beta cells Cells  metascape 
TranscriptomicsCOUP-TFII Controls Mouse Postnatal Pancreatic β-Cell Mass through GLP-1 β-Catenin
Pancreatic β-cells have the key homeostatic function of releasing insulin to keep blood glucose in the normal range. It is not fully understood how β-cell mass is determined. Ablation of a nuclear receptor, chicken ovalbumin upstream promoter transcription factor II (COUP-TFII), in mouse pancreat...
ORGANISM(S): Rattus norvegicus 
2011-10-06 | E-GEOD-30526 | biostudies-arrayexpress
TranscriptomicsInsulin Receptor-Overexpressing beta-Cells Ameliorate Hyperglycemia in Diabetic Rats through Wnt Signaling Activation
To investigate the therapeutic efficacy of beta-cells with IR manipulation, a plasmid containing human IR was stably introduced into rat beta-cell line INS-1 cells (namely, INS-IR cells). In the INS-IR cells, the role of cross-talk between insulin and Wnt signaling pathways in improving the function...
ORGANISM(S): Rattus norvegicus 
2013-06-11 | E-MEXP-3836 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Rattus norvegicus pancreatic beta cell line expressing HNF1b, HNF4a2 or HNF6
This SuperSeries is composed of the following subset Series:; GSE1589: Targets of HNF1b, HNF4a2 and HNF6 in INS-1 cells; GSE1590: Targets of HNF1b mutants in INS-1; GSE1591: INS-1 cell lines (FLP-In T-REx) Experiment Overall Design: Refer to individual Series
ORGANISM(S): Rattus norvegicus 
2007-11-29 | E-GEOD-6428 | biostudies-arrayexpress
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