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TranscriptomicsExpression profiling of Irgm1-/- (Lrg-47) HSCs
To assess gene expression changes in Irgm1 (Lrg-47) deficient HSCs Keywords: genetic modification, knockout A total of 6 samples were analyzed: 3 experimental replicates of Irgm1 HSCs were compared with 3 control replicates of WT HSCs
ORGANISM(S): Mus musculus 
2011-06-22 | E-GEOD-11591 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of bone marrow derived macophages (BMDMs) and brain tissue isolated from wild type and Irgm1 knockout mice
To understand the molecular mechanism by which Irgm1 controls innate immune homoestasis
ORGANISM(S): Mus musculus 
2020-09-01 | E-MTAB-9164 | biostudies-arrayexpress
ProteomicsTotal Synthesis and Target Identification of Marine Cyclopiane Diterpenes
We report our synthetic and chemical proteomics studies of marine cyclopiane diterpenes which culminate in the asymmetric total synthesis of conidiogenones C, K and 12β-hydroxy conidiogenone C, and identification of Immunity-related GTPase family M protein 1 (IRGM1) as a cellular target using an alk...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD056084 | Pride
Conidiogenone c 
TranscriptomicsIdentifying interferon-stimulated genes enriched in multiple tissues of Irgm1-/- mice
We observed enhanced epithelial proliferation secondary to elevated Type I IFNs in multiple tissues of Irgm1-/- mice. We discovered that Type I IFNs signaled through macrophages to promote this epithelial hyperproliferation. To determine candidate factors that could play a role in this process, we p...
ORGANISM(S): Mus musculus 
2015-01-03 | E-GEOD-59603 | biostudies-arrayexpress
TranscriptomicsExpression profiling of Irgm1-/- (Lrg-47) HSCs
To assess gene expression changes in Irgm1 (Lrg-47) deficient HSCs Keywords: genetic modification, knockout
ORGANISM(S): Mus musculus 
2011-06-23 | GSE11591 | GEO
UnknownIrgm1 regulates metabolism and function in T cell subsets.
Not available
S-EPMC8763923 | biostudies-literature
GenomicsHnRNPA2B1 tunes antimycobacterial immune responses in macrophages through alternative splicing of Irgm1
HnRNPA2B1 tunes antimycobacterial immune responses in macrophages through alternative splicing of Irgm1
PRJNA1379354 | ENA
UnknownIrgm1 protects hematopoietic stem cells by negative regulation of IFN signaling.
Not available
S-EPMC3156044 | biostudies-literature
TranscriptomicsRNA-seq of whole lungs from Irgm1-/- and wildtype littermates mice that were either uninfected or infected with influenza for 3, 6, or 10 days
We found that a dose of influenza (5,000 pfu of recombinant influenza A/WSN/33 (rWSN) H1N1 virus strain) that resulted in 50% mortality in wildtype littermate control mice showed minimal mortality in Irgm1-/- mice, indicating that Irgm1 deficiency was protective during influenza infection. This prot...
ORGANISM(S): Mus musculus 
2017-08-08 | E-MTAB-5337 | biostudies-arrayexpress
UnknownIRGM/Irgm1 facilitates macrophage apoptosis through ROS generation and MAPK signal transduction: Irgm1+/- mice display increases atherosclerotic plaque stability.
Not available
S-EPMC8490524 | biostudies-literature
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