ischemia/reperfusion

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Mus (2)
unidentified (1)
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Organisms

Mus musculus (466)
Rattus norvegicus (128)
Homo sapiens (71)
Sus scrofa (13)
unidentified (7)
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Oryctolagus cuniculus (3)
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Tissue

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Disease

Myocardial ischemia (12)
Cardiovascular system disease (5)
Acute kidney failure (3)
Ischemia (3)
Brain ischemia (3)
Normal (2)
Ischaemia reperfusion injury (1)
Cerebral ischemia (1)
The participants enrolled in this study will all undergo major upper abdominal surgery (i.e. mostly Pylorus Preserving Pancreatico Duodenectomy or whipple procedure) mostly for pancreatic cancer, papillary carcinoma or pancreatitis. However, the indication for which the IMP is administered is intestinal ischemia and reperfusion. (1)
Not Available (1)
Heart injury (1)
Coronary artery disease (1)
End stage renal disease (1)
Acute myocardial infarction (1)
Inflammation (1)
Hypertrophic cardiomyopathy (1)
Chronic kidney disease (1)
Wounds and Injuries (1)

Technology Type

Mass Spectrometry (89)
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Mass spectrometry assay (11)
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NMR spectroscopy (5)
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SWATH MS (3)
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EI (1)
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Instrument Platform

Liquid Chromatography MS - positive - reverse phase (12)
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NextSeq 550 (3)
Illumina NovaSeq 6000 (3)
NextSeq 2000 (2)
LTQ Orbitrap Elite (2)
TripleTOF 6600 (2)
Orbitrap Fusion (2)
Agilent 2100 Bioanalyzer, Applied Biosystems 7900HT Sequence Detection System, Illumina TruSeq Small RNA Sample Preparation Kit (1)
RNeasy mini Kit, Ribo-Zero Human/Mouse/Rat kit (1)
Agilent G2565BA Microarray Scanner System (Agilent Technologies) (1)
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428 [Affymetrix] (1)
ScanArray Express HT [PerkinElmer] (1)
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Illumina HiSeq 2500 (1)
Illumina HiSeq 2000 (1)
Illumina HiSeq 3000 (1)
Illumina HiSeq 4000 (1)
6495C Triple Quadrupole LC/MS (1)
Instrument (1)
ZenoTOF 7600 (1)
LTQ Orbitrap Velos (1)
Bruker timsTOF Pro (1)
TripleTOF 5600 (1)
Q Exactive (1)
Q Exactive Plus (1)
Q Exactive HF-X (1)

Publication Date

2025 (129)
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2023 (89)
2022 (67)
2021 (56)
2019 (51)
2020 (41)
2016 (39)
2010 (38)
2014 (28)
2015 (27)
2013 (25)
2011 (20)
2018 (17)
2017 (16)
2008 (16)
2012 (12)
2007 (12)
2009 (11)
2005 (4)
2006 (3)
2004 (1)
2002 (1)

UNIPROT ID/AC

Q9Y6Z7 (1)
Q9Y5C1 (1)
Q9UEW3 (1)
Q9UBT3 (1)
Q9P232 (1)
Q9NZK5 (1)
Q9NT22 (1)
Q9NQ38-3 (1)
Q9NQ38 (1)
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Q9BXJ4-3 (1)
Q9BXJ4 (1)
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Q96S96 (1)
Q96NZ9 (1)
Q96MK3 (1)
Q96H15 (1)
Q96BZ4 (1)
Q92832 (1)
Q8WWZ8 (1)
Q8WVN6 (1)
Q8NI99 (1)
Q8N6C8 (1)
Q8N3T6 (1)
Q8N149-2 (1)
Q8N149 (1)
Q8IZF2 (1)
Q8IYS5 (1)
Q8IXL6 (1)

ENSEMBL ID

ENSG00000229353 (1)
ENSG00000170477 (1)

CHEBI ID

CHEBI:16919 (9)
CHEBI:16704 (8)
CHEBI:17596 (8)
CHEBI:17368 (8)
CHEBI:16708 (7)
CHEBI:17154 (7)
CHEBI:16335 (7)
CHEBI:17568 (7)
CHEBI:7916 (7)
CHEBI:15891 (7)
CHEBI:16737 (7)
CHEBI:15354 (7)
CHEBI:18257 (6)
CHEBI:17562 (6)
CHEBI:16750 (6)
CHEBI:15741 (6)
CHEBI:17821 (6)
CHEBI:16235 (6)
CHEBI:18019 (6)
CHEBI:17203 (6)
CHEBI:18211 (6)
CHEBI:32816 (6)
CHEBI:16027 (6)
CHEBI:78320 (6)
CHEBI:16414 (6)
CHEBI:17191 (6)
CHEBI:15603 (6)
CHEBI:15756 (6)
CHEBI:30769 (6)
CHEBI:15682 (5)

Metabolite Name

Creatinine (13)
Creatine (10)
Thymine (9)
Adenosine (9)
Betaine (8)
L-Lysine (8)
Choline (8)
Taurine (8)
Adenine (8)
Uridine (8)
L-Valine (8)
Inosine (8)
Hypoxanthine (8)
Uracil (7)
Pyroglutamic acid (7)
L-Proline (7)
Ornithine (7)
Pantothenic acid (7)
Cytosine (7)
Palmitic acid (7)
Niacinamide (6)
Kynurenic acid (6)
L-Histidine (6)
Guanine (6)
L-Tryptophan (6)
Glycerophosphocholine (6)
L-Isoleucine (6)
L-Tyrosine (6)
Betaine aldehyde (5)
Beta-Alanine (5)

First Public Date

2024 (169)
2025 (163)
2026 (150)
2023 (99)
2022 (79)
2014 (73)
2021 (54)
2020 (49)
2019 (44)
2018 (15)
2017 (15)
2015 (13)
2016 (12)
2013 (4)

Modelling Approach

Mathematical model (1)
Ordinary differential equation model (1)

Study status

Ongoing (1)

Lab affiliation

Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain (3)
Department of Ophthalmology, Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third Hospital, Beijing, China (2)
Division of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology (2)
King's College London - Cardiovascular Division (2)
Proteomics Core Facility, Sahlgrenska Academy, University of Gothenburg, Sweden (2)
College of Biology, Hunan University, China (2)
Hubei University of Medicine, Taihe Hospital (2)
Anesthesiology & Perioperative Medicine Oregon Health & Science University 3181 SW Sam Jackson Park Road Portland, Oregon 97239, USA (1)
Department of Burns and Reconstructive Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China. (1)
Proteomic lab., Fondazione Ri.MED (1)
Departments of Medicine (Division of Cardiology), Virginia Commonwealth University, Richmond, VA, 23298 (1)
State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China (1)
Laboratoire de Spectrométrie de Masse BioOrganique (LSMBO), IPHC, UMR 7178, Université de Strasbourg, CNRS, 67087 Strasbourg, France; Infrastructure Nationale de Protéomique ProFI − FR2048 CNRS, 67087 Strasbourg, France (1)
Charles Perkins Centre, University of Sydney (1)
PROBE Dept of Biomedicine (1)
Instituto de Investigacion Biomediaca de A Coruna (INIBIC) - Complexo Hospitalario Universitario de A Coruna, A Coruna, SPAIN (1)
Wayne State University Chemistry Department, Ahn Lab, United States of America (Lab head) (1)
1) Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany 2) CECAD, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany (1)
National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University (1)
Target Discovery Institute, NDMRB, University of Oxford (1)
The First Affiliated Hospital of Zhengzhou University (1)
University Medical Center Groningen and University of Groningen (1)
Department of Integration of Chinese and Western Medicine, School of Basic Medical Sciences, Peking University (1)
Institute of Model Animal of Wuhan University, Wuhan, China. (1)
The Second Affiliated Hospital of Jiaxing University (1)
Tianjin Univerisity of Traditional Chinese Medicine (1)
Department of Liver Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, China (1)
Chengdu University of Traditional Chinese Medicine (1)
Department of Surgery, Maastricht University, Maastricht (1)
Multi-Organ Transplant, and Division of Nephrology, Department of Medicine. University Health Network, Toronto, Ontario, Canada. (1)

Keyword

Tranexmic acid (1)
Doxycycline (1)

IsPrivate

False (2)

Classification

bacteria (1)

Modification

144.105918 (1)
45.987721 (1)
-18.010565 (1)
-17.026549 (1)
42.010565 (1)
15.994915 (1)
2x(15)N labeled L-lysine (1)
4x(15)N labeled L-arginine (1)

Study type

Transcription profiling by array (110)
RNA-seq of coding RNA (9)
Unknown experiment type (7)
Transcription profiling by RT-PCR (4)
Animal - High-throughput sequencing (2)
Spatial transcriptomics by high-throughput sequencing (2)
ChIP-seq (2)
RNA-seq of coding RNA from single cells (2)
Animal - One-color microarray (1)
High-throughput sequencing (1)
MicroRNA profiling by high throughput sequencing (1)
Proteomic profiling by array (1)
RNA-seq of total RNA (1)
RNA-seq of non coding RNA (1)
Interventional (1)

Release Date

2022 (776)
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2023 (723)
2025 (716)
2024 (569)
2020 (545)
2019 (395)
2018 (362)
2017 (348)
2016 (299)
2015 (253)
2014 (219)
2013 (149)
2026 (120)
2012 (119)
2011 (110)
2010 (101)
2009 (60)
2008 (49)
2007 (27)
2005 (18)
2006 (17)
2004 (6)
2002 (4)
2003 (3)
1999 (2)
1997 (2)
2001 (1)
2000 (1)

Location

Netherlands (1)

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Time-Dependent Gene Profiling Indicates the Presence of Different Phases for Ischemia/Reperfusion Injury in Retina

The purpose of the present study was to investigate time-dependent changes in gene expression, following induction of IR in the rat retina, and to characterize the affected pathways, networks and processes. 6 biological replicates with two treatments (Sham control and Ischemia reperfusion) and 3 tim...

ORGANISM(S): Rattus norvegicus

2013-01-24 | E-GEOD-43671 | biostudies-arrayexpress

Pentose phosphate pathway-derived NADPH facilitates physiological hypertrophy and alleviates ischemia/reperfusion injury in the heart

Exercise promotes physiological cardiomyocyte growth and protects against ischemia/reperfusion (I/R) injury in the heart. The molecular mechanism by which exercise benefits cardiac metabolism and function remains largely unknown. Using a genetically encoded fluorescent indicator, we found that ex...

2026-03-22 | MTBLS14090 | MetaboLights

RNA-seq of rat myocardial tissue to investigate the cardioprotective mechanism of baicalin in myocardial ischemia-reperfusion injury

This study aimed to investigate the cardioprotective mechanism of baicalin (BAI) against myocardial ischemia-reperfusion injury (MIRI) in rats. We performed RNA-seq on left ventricular myocardial tissue from three groups: Sham (vehicle control), I/R (ischemia-reperfusion injury model), and I/R+BAI (...

ORGANISM(S): Rattus norvegicus

2026-07-31 | E-MTAB-17471 | biostudies-arrayexpress

CaM Kinase II mediates maladaptive post-infarct remodeling but not acute myocardial ischemia/reperfusion injury

Calcium/calmodulin-dependent protein kinase II (CaMKII) was suggested to mediate ischemic myocardial injury and adverse cardiac remodeling. However, the specific functions of the CaMKII isoforms and splice variants in ischemia/reperfusion (I/R) injury have not been investigated yet. Thus, we studied...

ORGANISM(S): Mus musculus

2014-09-08 | E-GEOD-58486 | biostudies-arrayexpress

small RNA-Seq of rat kidney in a model of ischemic preconditioning/ischemia-reperfusion injury

Ischemic preconditioning is effective in limiting subsequent ischemic acute kidney injury in experimental models. microRNAs are an important class of post-transcriptional regulator and show promise as biomarkers of kidney injury. An evaluation was performed of the time- and dose-dependent effects o...

ORGANISM(S): Rattus norvegicus

2021-12-31 | E-MTAB-9896 | biostudies-arrayexpress

Pentose phosphate pathway-derived NADPH facilitates physiological hypertrophy and alleviates ischemia/reperfusion injury in the heart

2026-04-13 | MTBLS14264 | MetaboLights

Exiqon miRCURY microRNA array of rat kidney in a model of ischemic preconditioning/ischemia-reperfusion injury

ORGANISM(S): Rattus norvegicus

2021-12-31 | E-MTAB-9900 | biostudies-arrayexpress

Global transcriptomic profiling of ischemic/reperfusion injury in an in vivo wild-type mouse model.

Ischemic stroke triggers severe focal hypoperfusion accompanied with deprivation of oxygen and glucose to the cerebral tissue, together with loss of ATP, depolorization of neurons, elevated extracellular potassium concentration, and subsequently leads to excitotoxicity as well as increased oxidative...

ORGANISM(S): Mus musculus

2011-01-10 | E-GEOD-23160 | biostudies-arrayexpress

TRIM47 promotes cardiac ischemia/reperfusion injury

This study shows that TRIM47 is upregulated in cardiomyocytes during cardiac I/R injury in an EGR1-dependent manner, correlating with injury severity. Cardiomyocyte-specific TRIM47 overexpression worsens, while TRIM47 knockout alleviates, I/R-induced cardiac injury and dysfunction. Mechanistically, ...

2026-08-28 | MTBLS14676 | MetaboLights

RNA microarray of rat kidney treated with or without silicon nano-particles against ischemia reperfusion injury

RNA microarray was performed to evaluate the efficacy of silicon nano-particles on renal transcriptomes of rats against ischemia reperfusion injury. We compared the transcriptomes of ischemia reperfusion injury model rats with or without oral administration of silicon nano-particles. We also tried t...

ORGANISM(S): Rattus norvegicus

2020-02-04 | E-MTAB-8687 | biostudies-arrayexpress

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