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MetabolomicsGut Microbiome and Metabolome Signatures in Calcium Oxalate Stone Recurrence: A Multi-Omics Study

Background: The incidence and recurrence rate of nephrolithiasis have been increasing annually. Recent evidence highlights a close association between the composition and function of the gut microbiome and the occurrence and recurrence of kidney stones. We performed a multi-omic study to investig...

2026-03-03 | MTBLS13960 | MetaboLights
TranscriptomicsKidney Stone Induces Developmental Stage-specific Alterations in Gene Expression
OBJECTIVES: Kidney stone diseases are common in premature infants, but the underlying molecular and cellular mechanisms are not fully defined. We carried out a prospective observational study using microarray analysis to identify factors that may be crucial for the initiation and progression of ston...
ORGANISM(S): Mus musculus 
2010-01-13 | E-GEOD-18160 | biostudies-arrayexpress
ProteomicsCharacterizations of HSP90-interacting complex in renal cells using tandem affinity purification and its potential role in kidney stone formation
Heat shock protein 90 (HSP90) is a highly abundant molecular chaperone that interacts with many other intracellular proteins to regulate various cellular processes. However, compositions of the HSP90-interacting complex remain underinvestigated. This study thus aimed to characterize such complex in ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-12-17 | MSV000083252 | MassIVE
ProteomicsProteomic analysis of urine and stone matrix of patients with kidney calculi
Proteins have been extracted from kidney calculi with SDS buffer. Proteins were seperated by 1D-SDS-PAGE and stained with coomassie. Each gel lane was cut into 5 (or 6) pieces. Proteins were digested in gel with trypsin. Tryptic peptides were analysed by nanoLC-MS/MS on an ion trap instrument (6340 ...
ORGANISM(S): Homo sapiens (Human) 
2016-07-11 | PXD000302 | Pride
Inflammation Kidney stone Fibrosis Biomarker 
ProteomicsProtective cellular mechanism of estrogen against kidney stone formation: A proteomics approach and functional validation
Kidney stone disease is influenced by multiple factors, including but not limited to age, gender, genetic background, hydration status, diet and drug. Regarding the gender, epidemiologic data across the world has shown that females at the reproductive age (15-49 years) have lower incidence/prevalenc...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2019-09-09 | PXD014768 | Pride
Female Kidney stone Nephrolithiasis Gender  hormone Estradiol 
ProteomicsIntegrated proteomics and transcriptomics profiling reveals distinct aspects of kidney stone related genes in calculi rats
We conducted a calculi rat model, applied for an integrated proteomic and transcriptomic analysis to characterize the distinct gene expression profiles in calculi oxalate stone formation and its related kidney injury. Six distinct gene clusters were identified according to the consistency of transcr...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-05-10 | PXD039169 | Pride
Calcium oxalate  kidney stone  proteomics  transcriptomics  urolithiasis 
ProteomicsUrinary proteins from stone formers promote calcium oxalate crystallization, growth and aggregation via oxidative modifications
Various urinary parameters have been used to determine kidney stone risk. However, almost all of the widely used lithogenic indices rely on urinary concentrations of small molecules/ions and pH. We hypothesized that urinary macromolecules (especially proteins) also play a critical role in determinin...
ORGANISM(S): Homo sapiens (Human) 
2026-03-09 | PXD050609 | Pride
Nephrolithiasis  oxidized protein  risk factor  stone modulator  urinary protein  urolithiasis 
ProteomicsCharacterizations of HSP90-interacting complex in renal cells using tandem affinity purification and its potential role in kidney stone formation
Heat shock protein 90 (HSP90) is a highly abundant molecular chaperone that interacts with many other intracellular proteins to regulate various cellular processes. However, compositions of the HSP90-interacting complex remain underinvestigated. This study thus aimed to characterize such complex in ...
ORGANISM(S): Homo sapiens (Human) 
2018-12-17 | PXD011432 | Pride
Chaperone  heat shock protein 90  hek293t  kidney stone  sirna  tap tag 
ProteomicsOxidative modifications of urinary proteins increase kidney stone risk
Clinical and animal studies have demonstrated the increasing evidence of oxidative stress in kidney stone disease. Recent findings have shown that the interactions between calcium oxalate (CaOx) crystals and renal tubular cells can promote many cellular events such as cell proliferation, cell death,...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD019360 | Pride
Calcium oxalate  kidney stone  oxidative stress  post-translation modification  uromodulin 
GenomicsAssessment of Health-Related Quality of Life in Rare Kidney Stone Formers in the Rare Kidney Stone Consortium - RKSC 6408
Assessment of Health-Related Quality of Life in Rare Kidney Stone Formers in the Rare Kidney Stone Consortium - RKSC 6408
PRJNA514816 | ENA
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