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MetabolomicsDistinct lipid signatures are identified in the plasma of rats with chronic inflammation induced by estradiol benzoate and sex hormones

INTRODUCTION: Prostatitis is likely to occur in younger or middle-aged men, while prostate cancer is likely to occur in older men. Although amino acids and lipids as biomarkers of prostate cancer have been examined using prostate cancer cell lines/tissues, no previous studies hav...

2020-11-04 | MTBLS2028 | MetaboLights
TranscriptomicsTranscription profiling of human umbilical vein endothelial cells after pulsed or continuous estradiol exposure
The experiment aims to investigate differences in the transcriptional response of human umbilical vein endothelial cells to estradiol treatment associated with the mode of administration. Human umbilical vein endothelial cells were treated for 5 days with a 1h pulse of 2.4 x 10-8 M 7β-estradiol (E2...
ORGANISM(S): Homo sapiens 
2008-08-29 | E-MEXP-1227 | biostudies-arrayexpress
TranscriptomicsInfluence of 17M-NM-2-estradiol on Gene Expression of Paracoccidioides During Mycelia-to-Yeast Transition
Background: Paracoccidioides is the causative agent of paracoccidioidomycosis, a systemic mycosis endemic to Latin America. Infection is initiated by inhalation of conidia (C) or mycelial (M) fragments, which subsequently differentiate into yeast (Y). Epidemiological studies show a striking predomin...
ORGANISM(S): Paracoccidioides brasiliensis Pb01 
2011-12-14 | E-GEOD-30466 | biostudies-arrayexpress
TranscriptomicsGENE EXPRESSION PROFILE REGULATED BY THE HPV16-E7 ONCOPROTEIN AND ESTRADIOL IN CERVICAL TISSUE
The HPV16-E7 oncoprotein and 17β-estradiol are import factors for the induction of premalignant lesions and cervical cancer. The study of these factors is crucial for a better understanding of cervical tumorigenesis. In this study, we performed a microarray analysis to obtain a global gene expressi...
ORGANISM(S): Mus musculus 
2013-07-01 | E-GEOD-46890 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human breast epithelia cells after 17-beta-estradiol induced malignant cell transformation
The estrogen-dependence of breast cancer has long been recognized, however, the role of 17β-estradiol (E2) in cancer initiation was not known until we demonstrated that it induces complete neoplastic transformation of the human breast epithelial cells MCF-10F. E2-treatment of MCF-10F cells progress...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-5116 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human MDA-MB-231 cells response to adenovirus expressed estradiol-ERalpha, estradiol-Erbeta, and ERE Binding defective mutants
This SuperSeries is composed of the following subset Series:; GSE9757: Response to estradiol-ERalpha; GSE9758: Response to estradiol-ERalpha ERE Binding defective mutant; GSE9759: Response to estradiol-Erbeta and estradiol-ERbeta ERE binding defective mutant Experiment Overall Design: Refer to indiv...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-9761 | biostudies-arrayexpress
TranscriptomicsSpecific transcriptional response of four blockers of estrogen receptors on estradiol-modulated genes in the mouse mammary gland
The efficacy and exceptionally good tolerance of estrogen blockade in the treatment of breast cancer is well recognized but novel agents are required, especially to take advantage of the multiple consecutive responses obtained in breast cancer progressing following previous hormone therapy, thus del...
ORGANISM(S): Mus musculus 
2012-12-05 | E-GEOD-35206 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation profiling of human breast cancer cell lines and tissues to identify novel estrogen receptor-{alpha} binding sites and estradiol target genes
Estrogen receptor-{alpha} (ER{alpha}) and its ligand estradiol play critical roles in breast cancer growth and are important therapeutic targets for this disease. Using chromatin immunoprecipitation (ChIP)-on-chip, ligand-bound ER{alpha} was recently found to function as a master transcriptional reg...
ORGANISM(S): Homo sapiens 
2008-06-20 | E-GEOD-11506 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human estrogen-responsive breast cancer cell lines treated with 17beta-estradiol for 1 to 32 hours
Human estrogen-responsive breast cancer cell lines ZR-75-1 and MCF-7 were treated with 10nM of 17beta-estradiol. Gene expression was analyzed on total RNA extracted before or after 1, 2, 4, 6, 8, 12, 16, 20, 24, 28 and 32 hours hormonal stimulation. For each condition 2 technical replicates were per...
ORGANISM(S): Homo sapiens 
2010-01-11 | E-TABM-742 | biostudies-arrayexpress
TranscriptomicsOpposing effects of estrogen and Runx2 on breast cancer cell proliferation: identification of a reciprocally-regulated gene signature with clinical prognostic value.
Analysis of reciprocal modulation of Runx2 and E2 signaling in BCA. Our objective was to investigate whether the interaction between estrogen and Runx2 signaling in breast cancer (BCa) could help refine an estrogen-responsive gene signature with improved prognostic value. MCF7/Rx2dox BCa cells condi...
ORGANISM(S): Homo sapiens 
2012-03-06 | E-GEOD-30597 | biostudies-arrayexpress
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