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Transcriptomicsp63+/Krt5+ Distal Airway Stem Cells are Essential for Lung Regeneration (Dtox treatment)
The possibility of lung regeneration has been long discounted due to the irreversible nature of chronic lung diseases. However, patients who sustain massive loss of lung tissue during acute infections often recover full pulmonary function. Correspondingly, we previously demonstrated lung regenerat...
ORGANISM(S): Mus musculus 
2014-11-20 | E-GEOD-60829 | biostudies-arrayexpress
Transcriptomicsp63+/Krt5+ Distal Airway Stem Cells are Essential for Lung Regeneration (transplanted and damaged)
The possibility of lung regeneration has been long discounted due to the irreversible nature of chronic lung diseases. However, patients who sustain massive loss of lung tissue during acute infections often recover full pulmonary function. Correspondingly, we previously demonstrated lung regenerat...
ORGANISM(S): Mus musculus 
2014-11-20 | E-GEOD-60830 | biostudies-arrayexpress
Transcriptomicsp63+/Krt5+ Distal Airway Stem Cells are Essential for Lung Regeneration (tracheal epithelium and alveoli)
The possibility of lung regeneration has been long discounted due to the irreversible nature of chronic lung diseases. However, patients who sustain massive loss of lung tissue during acute infections often recover full pulmonary function. Correspondingly, we previously demonstrated lung regenerat...
ORGANISM(S): Mus musculus 
2014-11-20 | E-GEOD-61091 | biostudies-arrayexpress
Transcriptomicsp63+/Krt5+ Distal Airway Stem Cells are Essential for Lung Regeneration (before and after in vitro differentiation)
The possibility of lung regeneration has been long discounted due to the irreversible nature of chronic lung diseases. However, patients who sustain massive loss of lung tissue during acute infections often recover full pulmonary function. Correspondingly, we previously demonstrated lung regenerat...
ORGANISM(S): Mus musculus 
2014-11-20 | E-GEOD-60828 | biostudies-arrayexpress
GenomicsMus musculus strain:Krt5-CreERT2
Mus musculus strain:Krt5-CreERT2 Raw sequence reads
PRJNA1248671 | ENA
GenomicsMus musculus strain:Krt5-CreERT2
Mus musculus strain:Krt5-CreERT2 Raw sequence reads
PRJNA1249066 | ENA
ProteomicsLung extracellular matrix modulates KRT5+ basal cell activity in pulmonary fibrosis
Aberrant expansion of KRT5+ basal cells in the distal lung accompanies progressive alveolar epithelial cell loss and tissue remodelling during fibrogenesis in idiopathic pulmonary fibrosis (IPF). The mechanisms determining activity of KRT5+ cells in IPF have not been delineated. Here, we show an ass...
ORGANISM(S): Homo sapiens (Human) 
2023-09-28 | PXD037236 | Pride
Human Ecm Lung Fibrosis 
UnknownCAV1 and KRT5 are potential targets for prostate cancer.
Not available
S-EPMC10713156 | biostudies-literature
TranscriptomicsTranscription profiling of mouse tracheal basal cells
Epithelial basal cells (BCs) are an important stem cell population of the airways. We purified BCs from a KRT5-GFP transgenic mouse line and used Affymetrix arrays to compare there gene expression to that of non-BC epithelium. Experiment Overall Design: Three populations of cells were obtained by F...
ORGANISM(S): Mus musculus 
2009-07-11 | E-GEOD-15724 | biostudies-arrayexpress
UnknownLung extracellular matrix modulates KRT5+ basal cell activity in pulmonary fibrosis.
Not available
S-EPMC10533905 | biostudies-literature
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