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ProteomicsKu80 interaction proteins under enhanced mitophagy
We reported Ku80 as a critical mitophagy protein and closely related to chemotherapy efficacy in liver cancer. The project detects the Ku80-interacted proteins under the condition of mitophagy activator or exogenously overexpression of Ku80 gene. After immunoprecipitation pulldown via anti-Ku80 or ...
ORGANISM(S): Homo sapiens (Human) 
2026-05-14 | PXD062704 | Pride
Ku80 Mitophagy activator Liver cancer 
TranscriptomicsHost gene expression response to Toxoplasma gondii infection is not different between RH?ku80 and RH?ku80?rop5 parasites.
The normally virulent type-I RH parasite is rendered avirulent when lacking ROP5. The avirulent phenotype is a consequence of interaction with the host innate immune system. We sought to understand if ROP5 alters host gene expression in order to escape host defenses. We saw no gene expression differ...
ORGANISM(S): Homo sapiens 
2012-09-13 | E-GEOD-32104 | biostudies-arrayexpress
GenomicsAspergillus fumigatus strain:KU80
Aspergillus fumigatus strain:KU80 Transcriptome or Gene expression
PRJNA245546 | ENA
GenomicsKu80/Ku70 complex associated RNA in HEK293T cells
Ku80/Ku70 complex associated RNA in HEK293T cells
PRJNA907753 | ENA
GenomicsComplementation of KU80
Functional diversification of Paramecium Ku80 paralogs allows coupling between cleavage and repair during programmed DNA elimination
PRJEB34438 | ENA
ProteomicsKu80 lysine crotonylation conversion to SUMOylation facilitates DNA non-homologous end joining and cellular resistance to radiation
A DNA double-strand break (DSB) is the most serious DNA damage and is also the principal molecular basis of radiotherapy. Upon DNA damage, the Ku80 is recruited and forms a critical DNA-PK complex at the DSB sites with Ku70 and the catalytic subunit (DNA-PKcs) to initiate DNA repair. How DNA-PK is a...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD061039 | Pride
Dna double-strand break repair  ku80  crotonylation  sumoylation  dna-pk holoenzyme assembly  radioresistance 
TranscriptomicsHost gene expression response to Toxoplasma gondii infection is not different between RH∆ku80 and RH∆ku80∆rop5 parasites
The normally virulent type-I RH parasite is rendered avirulent when lacking ROP5. The avirulent phenotype is a consequence of interaction with the host innate immune system. We sought to understand if ROP5 alters host gene expression in order to escape host defenses. We saw no gene expression differ...
ORGANISM(S): Homo sapiens 
2012-09-13 | GSE32104 | GEO
TranscriptomicsKu80/Ku70 complex associated RNA in HEK293T cells
We report the Ku80/Ku70 complex associated RNA in HEK293T cells using RNA-seq following PAR-Clip.
ORGANISM(S): Homo sapiens 
2024-04-09 | GSE219220 | GEO
UnknownCalcium influx-mediated translocation of m-calpain induces Ku80 cleavage and enhances the Ku80-related DNA repair pathway.
Not available
S-EPMC5058721 | biostudies-literature
UnknownBy downregulating Ku80, hsa-miR-526b suppresses non-small cell lung cancer.
Not available
S-EPMC4359307 | biostudies-literature
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