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MetabolomicsLactate-driven lysine lactylation mediates high-level colistin resistance in Salmonella
Intracellular pathogens are particularly refractory to antibiotic eradication, leading to persistent and relapsing infections. However, how intracellular metabolic microenvironments shape antibiotic resistance phenotypes remains poorly understood. Here we delineate a metabolic-regulatory axis wherei...
2026-06-17 | MTBLS14781 | MetaboLights
MetabolomicsProtein lactylation of citrate synthase promotes the AKI–CKD transition by activating the NLRP3 inflammasome.

Interstitial renal inflammation contributes to the transition from acute kidney injury (AKI) to chronic kidney disease (CKD). Recently, protein lactylation modification has emerged as a novel mechanism for mediating chronic organ damage. We investigated lactylated protein profiles and the role of...

2025-06-17 | MTBLS12606 | MetaboLights
ProteomicsGlobal Lactylation Profiling Reveals Lactate-Driven Regulatory Mechanisms Promoting Tumor Progression in Oral Carcinoma
Cancer cells often rely on aerobic glycolysis for metabolism, and lactylation, a newly discovered post-translational modification, significantly impacts molecular processes. This study comprehensively analyzes lactylation's role in oral squamous cell carcinoma (OSCC), providing initial insights into...
ORGANISM(S): Homo sapiens (Human) 
2024-08-23 | PXD047673 | Pride
Human Proteome Oral cancer 
ProteomicsLactylation of Tau in Human Alzheimers Disease Brain
Aggregation of phosphorylated tau is associated with cognitive impairment in Alzheimers disease patients. In AD a metabolic shift due to the Warburg effect results in increased lactate production. Lactate can induce a post-translational modification on proteins that conjugates lactyl groups to lysin...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000095881 | MassIVE
ProteomicsGlobal Profiling of Protein Lactylation Across Subcellular Fractionation Methods in HCT-116
Protein lactylation is a novel post-translational modification (PTM) involved in many important physiological processes such as macrophage polarization, immune regulation and tumour cell growth. However, most studies to date have focused on the function of lactylation on histones, and little is know...
ORGANISM(S): Homo sapiens (Human) 
2024-12-15 | PXD053474 | Pride
Post-translation modification Subcellular fractionation method Lactylation 
ProteomicsToxoplasma gondii; protein posttranslational modification; lactylation; metabolism; function
Toxoplasma gondii, a single-celled protozoan parasite (phylum Apicomplexa) and remains the causative pathogen of one of the most wide-spread infectious diseases, toxoplasmosis. To continuously proliferate in warm-blooded animals, this parasite undergoes repeated cycles of invasion, division and indu...
ORGANISM(S): Toxoplasma gondii 
2024-04-07 | PXD022700 | Pride
Toxoplasma gondii 
ProteomicsProtein Lactylation modification and Proteomics Features in Cirrhosis Patients after MSCs Treatment.
Mesenchymal stem cell (MSC) therapy improves liver function in patients with liver cirrhosis. However, the therapeutic mechanism underlying MSC therapy remains unclear. Therefore, this study aimed to elucidate the therapeutic mechanism underlying MSC therapy by analyzing changes in the modification ...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD037530 | Pride
Liver cirrhosis  mesenchymal stem cell  cell therapy  lactylation modification  proteomics analysis. 
ProteomicsGlobal Lactylation Profiling Reveals Lactate-Driven Regulatory Mechanisms Promoting Tumor Progression in Oral Squamous Cell Carcinoma
Cancer cells often rely on aerobic glycolysis for metabolism, and lactylation, a newly discovered post-translational modification, significantly impacts molecular processes. This study comprehensively analyzes lactylation's role in oral squamous cell carcinoma (OSCC), providing initial insights into...
ORGANISM(S): Homo sapiens (Human) 
2024-08-23 | PXD047535 | Pride
Human Proteome Oral cancer 
ProteomicsSystematic profiling of lysine lactylation proteome reveals distinct changes in lactylation between the parental AGS cells and cisplatin-resistant AGS cells
Lactate enable to cause a novel post-translational modification, lactylation of proteins. We are interested in exploring whether lactate modulates DNA-damaging agents resistance in the form of lactylation. To gain a global view of DNA-damaging agents resistance-related lactylation, especially Kla of...
ORGANISM(S): Homo sapiens (Human) 
2024-05-09 | PXD050906 | Pride
Lysine lactylation 
ProteomicsA Bioorthogonal Chemical Reporter for the Detection and Identification of Protein Lactylation
L-Lactylation is a recently discovered post-translational modification occurring on histone lysine residues to regulate gene expression. However, the substrate scope of lactylation, especially that in non-histone proteins, remains unknown, largely due to the limitations of current methods for analyz...
ORGANISM(S): Homo sapiens (Human) 
2022-06-23 | PXD033454 | Pride
Chemical reporter Chemical proteomics Lactylation 
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