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MetabolomicsDietary leucine restriction remodels the gut microbiota and serum glycerophospholipids to combat obesity

Abstract

Background The gut microbiota mediates dietary impacts on host metabolism, but the roles of specific amino acids remain elusive. We investigated the mechanism by which dietary leucine restriction combats obesity.

Methods Combining Mendelian randomization in humans with interv...

2025-11-07 | MTBLS13281 | MetaboLights
MetabolomicsLeucine degradation metabolite ratio as a measure of meropenem susceptibility in carbapenem-resistant Klebsiella pneumoniae

Rapid detection of carbapenem-resistant Klebsiella pneumoniae (CRKP) is essential for effective clinical management and surveillance. This study investigated volatile organic compounds (VOCs) as phenotypic biomarkers of carbapenem resistance, with the goal of developing a translationally...

2026-06-09 | MTBLS13539 | MetaboLights
MetabolomicsMetabolome and proteome changes in skeletal muscle and blood of pre-weaning calves fed leucine and threonine supplemented diets

In pre-weaning calves, both leucine and threonine play important roles in growth and muscle metabolism. In this study, metabolomics, proteomics and clinical chemistry were used to assess the effects of leucine and threonine supplementation added to milk replacer on 14 newborn Holstein male calves...

2020-02-20 | MTBLS1045 | MetaboLights
MetabolomicsL-leucine increases the sensitivity of drug-resistant Salmonella to sarafloxacin by stimulating central carbon metabolism and increasing intracellular reactive oxygen species level (LC-MS positive mode)

The overuse of antibiotics has made public health and safety face a serious crisis. It is urgent to develop new clinical treatment methods to combat drug-resistant bacteria to alleviate the health crisis. The efficiency of antibiotics is closely related to the metabolic state of bacteria. However...

2023-05-02 | MTBLS7711 | MetaboLights
MetabolomicsL-leucine increases the sensitivity of drug-resistant Salmonella to sarafloxacin by stimulating central carbon metabolism and increasing intracellular reactive oxygen species level (LC-MS negative mode)

The overuse of antibiotics has made public health and safety face a serious crisis. It is urgent to develop new clinical treatment methods to combat drug-resistant bacteria to alleviate the health crisis. The efficiency of antibiotics is closely related to the metabolic state of bacteria. However...

2023-05-02 | MTBLS7713 | MetaboLights
MetabolomicsCatabolism of branched-chain amino acids (BCAAs) in renal cells HK2 and 786-O
Not available
ORGANISM(S): Homo sapiens 
ST002220 | MetabolomicsWorkbench
TranscriptomicsGenome-wide analysis of muscle gene expression in response to an intense cycling exercise. Effect of two protein-leucine enriched diets
Protein-leucine supplement ingestion following strenuous endurance exercise accentuates skeletal-muscle protein synthesis and adaptive molecular responses, but the underlying transcriptome is uncharacterized. In a randomized single-blind triple-crossover design, 12 trained men completed 100 min of h...
ORGANISM(S): Homo sapiens 
2015-11-23 | E-GEOD-44818 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human HepG2/C3A cells cultured in complete or leucine-devoid medium
HepG2/C3A cells cultured for 42 h in complete or leucine-devoid medium Experiment Overall Design: Total of 6 Samples (Leu vs noLeu)
ORGANISM(S): Homo sapiens 
2008-11-15 | E-GEOD-13142 | biostudies-arrayexpress
MetabolomicsTime sensitive contribution of the BCAA catabolism to the TCA cycle carbons in HK2, 786-O, OS-RC-2 and RFX-631
Not available
ORGANISM(S): Homo sapiens 
ST002225 | MetabolomicsWorkbench
MetabolomicsChemoresistant Cancer Cell Lines are Characterized by Migratory, Amino Acid Metabolism, Protein Catabolism and IFN1 Signalling Perturbations
Not available
ORGANISM(S): Homo sapiens 
ST002104 | MetabolomicsWorkbench
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