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TranscriptomicsTranscription profiling by array of human HepG2/C3A cells cultured in complete or leucine-devoid medium
HepG2/C3A cells cultured for 42 h in complete or leucine-devoid medium Experiment Overall Design: Total of 6 Samples (Leu vs noLeu)
ORGANISM(S): Homo sapiens 
2008-11-15 | E-GEOD-13142 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of cells starved of leucine in the presence or absence of a dominant negative HSF1 mutant (dnHSF1, HSF379).
Cells were starved for leucine in the presence or absence of a dominant negative HSF1 mutant (dnHSF1, HSF379). Changes in transcriptome relative to cells cultured with leucine were determined. The experiment shows the effect of dnHSF on the amino acid starvation response.
ORGANISM(S): Homo sapiens 
2012-12-11 | E-MEXP-3563 | biostudies-arrayexpress
ProteomicsProteome and Crotonylome of normal and leucine deprivation treated AML12 cells
Leucine, as a branched amino acid, is not only a substrate for protein synthesis, but also a signaling molecule that affects many biological processes. Lysine crotonylation is a novel post-translational modification in both histone and non-histone proteins. What effect amino acids have on crotonylat...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-10 | PXD018118 | Pride
Proteome  crotonylome  leucine deprivation 
TranscriptomicsExpression data from undifferentiated human ES cell line, khES3 grown using complete, leucine or lysine deprived media
In undifferentiated human ES cells, 48hr Leucine deprivation (delta Leu) or Lysine deprivation (delta Lys) led to apoptosis. We used microarrays to detail the mollecular mechanism of cell-death caused by Leu, Lys deprivation in undifferentiated ES cells. Cells were harvested at undifferentiated stag...
ORGANISM(S): Homo sapiens 
2014-04-17 | E-GEOD-55284 | biostudies-arrayexpress
GenomicsExpression data from 1. leucine deprivation and 2. ATF4 overexpression on HepG2 cells
Expression data from 1. leucine deprivation and 2. ATF4 overexpression on HepG2 cells
PRJNA858810 | ENA
GenomicsLiver RNA sequencing data from wildtype and DKO mice during dietary leucine deprivation or control feeding
Liver RNA sequencing data from wildtype and DKO mice during dietary leucine deprivation or control feeding
PRJNA812066 | ENA
GenomicsChemotherapeutic agents and leucine deprivation induce codon-biased aberrant protein production in cancer
Chemotherapeutic agents and leucine deprivation induce codon-biased aberrant protein production in cancer
PRJNA1158720 | ENA
GenomicsExpression data from 1. leucine deprivation and 2. ATF4 overexpression on HepG2 cells
The mechanistic target of rapamycin complex 1 (mTORC1) is involved in nutrient-induced signaling and is a master regulator of cell growth and metabolism. Amino acid-deficient conditions affect mTORC1 activity; however, its upstream regulators warrant further investigation. MicroRNAs are key regulato...
ORGANISM(S): synthetic construct Homo sapiens 
2022-07-15 | GSE208228 | GEO
TranscriptomicsLiver RNA sequencing data from wildtype and DKO mice during dietary leucine deprivation or control feeding
The goal of this project is to perform a systemic analysis of transcriptional responses in the liver of WT and Sestrin DKO mice during dietary leucine deprivation.
ORGANISM(S): Mus musculus 
2022-07-01 | GSE197806 | GEO
UnknownLeucine deprivation results in antidepressant effects via GCN2 in AgRP neurons.
Not available
S-EPMC11748975 | biostudies-literature
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