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TranscriptomicsT cell acute leukaemia development and chemo-resistance are mediated by dynamic interactions with heterogeneous bone marrow microenvironments.
It is widely accepted that complex interactions between cancer cells and their surrounding microenvironment contribute to disease development, chemo-resistance and disease relapse. In light of this observed interdependency, novel therapeutic interventions that target specific cancer stroma cell line...
ORGANISM(S): Homo sapiens 
2016-07-01 | E-MTAB-4889 | biostudies-arrayexpress
UnknownTherapeutic Targeting of the Leukaemia Microenvironment.
Not available
S-EPMC8267786 | biostudies-literature
TranscriptomicsTranscription profiling by array of human bone marrow and peripheral blood CD34+ myeloblasts in acute myeloid leukaemia
To examine the differences between bone marrow (BM) and peripheral blood (PB) myeloblasts in acute myeloid leukaemia (AML), we compared CD34+ myeloblasts of paired BM and peripheral blood (PB) samples from AML patients using microarray. Experiment Overall Design: 5 paired BM and PB leukaemic samples...
ORGANISM(S): Homo sapiens 
2008-10-26 | E-GEOD-12326 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of acute lymphoblastic leukaemia patient samples that represent six different subgroups defined by cytogenetic features and immunophenotype
We examined published microarray data from 104 acute lymphoblastic leukaemia patient specimens, that represent six different subgroups defined by cytogenetic features and immunophenotypes. Using the decision-tree based supervised learning algorithm Random Forest (RF), we determined a small set of ge...
ORGANISM(S): Homo sapiens 
2007-05-11 | E-TABM-125 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human T cell leukaemia cell line Jurkat that were retrovirally transduced with constitutievely active forms of Notch to identify novel transcriptional targets of Notch signalling
In this study we aimed to identify novel transcriptional targets of Notch signalling in the T cell leukaemia cell line, Jurkat. RNA was prepared from Jurkat cells retrovirally transduced with an empty vector (Mock) or vectors containing constitutively active forms of Notch (N1deltaE or N3deltaE), an...
ORGANISM(S): Homo sapiens 
2009-07-15 | E-MEXP-1744 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human indolent and aggressive forms of Chronic Myeloid Leukaemia (CML)
Title: Gene expression analysis of indolent and aggressive forms of Chronic Myeloid Leukaemia (CML). Description: Chronic Myeloid Leukaemia presents in chronic phase (CP) and terminates in 'blast crisis'. Despite a common abnormality, the duration of CP is variable. The aim is to compare the gene...
ORGANISM(S): Homo sapiens 
2013-01-30 | E-MIMR-17 | biostudies-arrayexpress
UnknownMutational cooperativity of RUNX1::RUNX1T1 isoform 9a and oncogenic NRAS in zebrafish myeloid leukaemia.
Not available
S-EPMC11381922 | biostudies-literature
UnknownIdarubicin, cytarabine, and nivolumab in patients with newly diagnosed acute myeloid leukaemia or high-risk myelodysplastic syndrome: a single-arm, phase 2 study.
Not available
S-EPMC6778960 | biostudies-literature
TranscriptomicsGenomic profiling of Imatinib resistance in CD34+ cell populations from chronic myeloid leukaemia patients using Agilent-014698 Whole Human Genome 105K microarrays.
To ascertain genomic alterations associated with Imatinib resistance in chronic myeloid leukaemia, we performed high resolution genomic analysis of CD34+ cells from 25 Imatinib (IM) resistant and 11 responders CML patients. Using patients' T-cells as reference, we found significant association betwe...
ORGANISM(S): Homo sapiens 
2010-11-15 | E-GEOD-21986 | biostudies-arrayexpress
TranscriptomicsDiscovery of novel recurrent mutations and rearrangements in early T-cell precursor acute lymphoblastic leukemia by whole genome sequencing
Early T-cell precursor acute lymphoblastic leukaemia (ETP ALL) is an aggressive malignancy of unknown genetic basis. We performed whole genome sequencing of tumour and normal DNA from 12 children with ETP ALL and assessed the frequency of somatic alterations in 52 ETP and 42 non-ETP T-ALL samples by...
ORGANISM(S): Homo sapiens 
2011-11-23 | E-GEOD-28703 | biostudies-arrayexpress
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