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MetabolomicsLipidomic analysis reveals altered lipid profiles of clinically healthy and periodontitis-affected gingival biopsies

AIM: The role of lipids in periodontitis has not been well studied. Thus, this study aimed to explore periodontitis-associated lipid profile changes and identify differentially expressed lipid metabolites in gingival tissues.

MATERIALS AND METHODS: Gingival...

2022-08-19 | MTBLS4684 | MetaboLights
ProteomicsMicrovesicle Proteomic profiling of Uterine Liquid Biopsy for Ovarian Cancer Early Detection
High-grade ovarian cancer (HGOC) is the leading cause of mortality from gynecological malignancies, due to diagnosis at a metastatic stage. Current screening options fail to improve mortality due to the absence of early-stage-specific biomarkers. We postulated that a liquid biopsy, such as utero-tub...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-09-19 | MSV000084345 | MassIVE
GenomicsEvaluating Liquid Biopsies for Methylomic Profiling of Prostate Cancer
Evaluating Liquid Biopsies for Methylomic Profiling of Prostate Cancer
PRJNA488624 | ENA
ProteomicsHuman colon biopsies (healthy and Ulcerative Colitis) LC-MS/MS
The etiology of the inflammatory bowel diseases, including ulcerative colitis, remains incomplete, but recent findings points to the involvement of complex host-microbial interactions. We hypothesized that an analysis of the proteins on the host-microbial interacting surface, the intestinal mucosa, ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080833 | MassIVE
TranscriptomicsLiquid Biopsy-Based Single-Cell Transcriptome Profiling Characterizes Heterogeneity of Disseminated Tumor Cells from Lung Adenocarcinoma
To decipher the heterogeneity and distinct molecular signatures of disseminated tumor cells, we profiled the transcriptomes single cells from malignant pleural effusion. RNA-seq was done using the standard 10x chromium v3 chemistry.
ORGANISM(S): Homo sapiens 
2020-09-01 | E-MTAB-8530 | biostudies-arrayexpress
GenomicsWhole transcriptome profiling of liquid biopsies from tumour xenografted mouse models: validation cohort
While cell-free DNA (cfDNA) in liquid biopsies is widely being used and investigated, free circulating RNA (extracellular RNA, exRNA) has the potential to improve therapy response monitoring and cancer detection due to its dynamic nature. A fundamental open question hampering the initiation of large...
EGAS00001006582 | EGA
ProteomicsAscending colon biopsies from pediatric patients
We sought to identify proteins that enable differentiation between CD and UC in children with new onset IBD. Mucosal biopsies were obtained from children undergoing baseline diagnostic endoscopy prior to therapeutic interventions. Using a super-stable isotope labeling with amino acids in cell cultur...
ORGANISM(S): Homo sapiens (Human) 
2018-11-06 | PXD005086 | Pride
Colon Lcmsms 
Methylation profilingEvaluating Liquid Biopsies for Methylomic Profiling of Prostate Cancer
Liquid biopsies offer significant potential for informing on cancer progression and therapeutic resistance via minimally invasive serial monitoring of genetic alterations. Although the cancer epigenome is a central driving force in most neoplasia, how well the tumour methylome can be monitored via l...
ORGANISM(S): Homo sapiens 
2020-04-22 | GSE119260 | GEO
UnknownThe Polemic Diagnostic Role of TP53 Mutations in Liquid Biopsies from Breast, Colon and Lung Cancers.
Not available
S-EPMC7696715 | biostudies-literature
ProteomicsPre-Analytical Framework for Routine Clinical Use of Liquid Biopsies: Combining EVs and cfDNA
Liquid biopsies hold significant potential for the non-invasive diagnostics of tumors and other diseases. While the clinical application of cell-free DNA (cfDNA) methodologies is emerging, the implementation of tumor-derived extracellular vesicles (EVs) as validated biomarkers is hindered by substan...
ORGANISM(S): Homo sapiens (Human) 
2026-01-23 | PXD062837 | Pride
Extracellular vesicles Liquid biopsy Cfdna Human plasma Tube preservation Isolation protocol Pre-analytics Translation 
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