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MetabolomicsMetabolomic profiling reveals the effects of early-life lactoferrin intervention on protein synthesis, energy production and antioxidative capacity in the liver of suckling piglets

The objective of this study was to reveal the effects of early life lactoferrin intervention on the liver metabolism in the suckling piglets. Sixty newborn piglets with an average initial body weight (BW) of 1.51 ± 0.05 kg were assigned to the control (CON) group and the lactoferrin (LF) group. P...

2022-03-01 | MTBLS2279 | MetaboLights
MetabolomicsFirst-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure

Diminished hepatocyte regeneration is a key feature of acute and chronic liver diseases and after extended liver resections, resulting in the inability to maintain or restore a sufficient functional liver mass. Therapies to restore hepatocyte regeneration are lacking, making liver transplantation...

2024-09-23 | MTBLS9434 | MetaboLights
MetabolomicsAntidiabetic and cardiovascular beneficial effects of a liver-localized mitochondrial uncoupler
Inducing mitochondrial uncoupling (mUncoupling) is an attractive therapeutic strategy for treating metabolic diseases because it leads to calorie-wasting by reducing the efficiency of oxidative phosphorylation (OXPHOS) in mitochondria. Here we report a safe mUncoupler, OPC-163493, which has unique p...
2019-05-24 | MTBLS836 | MetaboLights
MetabolomicsZEB1 Maintains Energy Metabolism to Sustain Cardiac Function Through Synergistic Regulation with TEAD1
Metabolic reprogramming plays a critical role in heart failure (HF), but its regulatory mechanisms remain incompletely understood. Zinc finger E-box binding homeobox 1 (ZEB1), a transcription factor initially identified as a regulator of epithelial-mesenchymal transition, has recently been implicate...
2026-09-28 | MTBLS15833 | MetaboLights
MetabolomicsSupplementing RP-Arg during the gestation and lactation periods of grazing sheep reprograms liver metabolism in offspring lambs by increasing IGF-1 in milk

The nutritional status of ewes during gestation and lactation is a key determinant of lamb growth performance. Supplementing rumen-protected arginine (RP-Arg) during these stages induces maternal metabolic adaptation, thereby maintaining fetal developmental homeostasis. However, the sustained eff...

2025-10-30 | MTBLS13239 | MetaboLights
MetabolomicsGlobal 13C tracing and metabolic flux analysis of intact human liver tissue ex vivo
Liver metabolism is central to human physiology and influences the pathogenesis of common metabolic diseases. Yet, our understanding of human liver metabolism remains incomplete, with much of current knowledge based on animal or cell culture models that do not fully recapitulate human physiology. He...
2024-07-23 | MTBLS10481 | MetaboLights
MetabolomicsPenthorum chinense Pursh Ameliorates Metabolic Dysfunction-Associated Alcohol-Related Liver Disease through Gut Microbiota Modulation and Metabolic Remodeling
Metabolic dysfunction-associated alcohol-related liver disease (MetALD) is characterized by hepatic steatosis, oxidative stress, inflammation, and gut microbiota dysbiosis resulting from the coexistence of metabolic dysfunction and alcohol consumption. Penthorum chinense Pursh is a traditional edibl...
2026-06-10 | MTBLS14735 | MetaboLights
MetabolomicsSMN deficiency perturbs monoamine neurotransmitter metabolism in spinal muscular atrophy

Beyond motor neuron degeneration, homozygous mutations in the survival motor neuron 1 (SMN1) gene cause multiorgan and metabolic defects in patients with spinal muscular atrophy (SMA). However, the precise biochemical features of these alterations and the age of onset in the brain and peripheral ...

2023-11-27 | MTBLS8784 | MetaboLights
TranscriptomicsDichlorvos exposure results in large scale disruption of energy metabolism in the liver of the zebrafish, Danio rerio
Background: Exposure to dichlorvos (DDVP), an organophosphorus pesticide, is known to result in neurotoxicity as well as other metabolic perturbations. However, the molecular causes of DDVP toxicity are poorly understood, especially in cells other than neurons and muscle cells. To obtain a better un...
ORGANISM(S): Danio rerio 
2015-11-05 | E-GEOD-66257 | biostudies-arrayexpress
MetabolomicsChanges and correlations of intestinal flora and liver metabolite profiles in mice with gallstones

There is increased appreciation for the roles of the gut-liver axis in liver and gall diseases. Specific gut microbes are associated with susceptibility to gallstone diseases,while the relationship between intestinal flora and liver metabolism in the formation of gallstones remains unclear. C57BL...

2021-08-05 | MTBLS2945 | MetaboLights
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