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MetabolomicsLKB1 inactivation elicits a NNMT-mediated methyl sink and confers dependence on PRMT5 in lung cancer
The protein arginine methyl transferase 5 (PRMT5) emerges as a therapeutic target in S-methyl-5'-thioadenosine phosphorylase (MTAP)-deleted cancers, where MTA accumulation partially inhibits its activity. However, It remains unclear whether other genetic alterations can dictate PRMT5 activity in can...
2026-04-30 | MTBLS14411 | MetaboLights
TranscriptomicsLKB1 modulates lung cancer differentiation and metastasis
Inherited mutation in LKB1 results in the Peutz-Jeghers syndrome (PJS), characterized by intestinal hamartomas and a modestly increased frequency of gastrointestinal and breast cancer1. Somatic inactivation of LKB1 occurs in human lung adenocarcinoma2-4, but its tumor suppressor role in this tissue ...
ORGANISM(S): Homo sapiens 
2007-08-28 | E-GEOD-6135 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of Lkb1 WT and KO hematopoietic stem cells (HSCs)
LKB1 encodes a Ser/Thr kinase and acts as an evolutionarily conserved sensor of cellular energy status in eukaryotic cells. LKB1 functions as the major upstream kinase to phosphorylate AMPK and 12 other AMPK-related kinases, which is required for their activation in many cellular contexts. Once acti...
ORGANISM(S): Mus musculus 
2010-12-01 | E-GEOD-24765 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Mus musculus gastric Lkb1 polyps vs unaffected gastric Lkb1 mucosa
Gene expression in wildtype mouse stomach wall (n=6), Lkb1+/- mouse stomach wall (n=6) and Lkb1+/- mouse gastric polyps
ORGANISM(S): Mus musculus 
2010-10-06 | E-MEXP-2444 | biostudies-arrayexpress
TranscriptomicsLKB1/STK11 Inactivation Leads to Expansion of Pro-Metastatic Tumor Sub-Population in Melanoma
Germline mutations in LKB1 (STK11) are associated with the Peutz–Jeghers syndrome (PJS), which includes aberrant mucocutaneous pigmentation, and somatic LKB1 mutations occur in 10% of cutaneous melanoma. By somatically inactivating Lkb1 with K-Ras activation (+/- p53 loss) in murine melanocytes, we ...
ORGANISM(S): Mus musculus 
2012-06-24 | E-GEOD-34866 | biostudies-arrayexpress
TranscriptomicsExpression profile of A459 cells upon LKB1 expression
The purpose of the experiment is to study the expression profiles variations upon the expression of the wild type isoform of LKB1 (STK11) in human lung carcinoma A459 cells. These cells are KRAS mutated and null for STK11. Cells were previously infected with the lentiviral construct pLenti-rtTA2-IRE...
ORGANISM(S): Homo sapiens 
2020-06-11 | E-MTAB-8863 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by high throughput sequencing of pancreatic islets from LKB1 and AMPK knockout mice
RNA-Seq was performed on pancreatic islets from four transgenic mouse strains affecting LKB1 and AMPK. A conditional LKB1 knockout strain was generated. Double conditional knockouts for AMPK alpha1 and AMPK alpha2 were also generated. These conditional strains were crossed with RIP-Cre (driven by ra...
ORGANISM(S): Mus musculus 
2014-10-25 | E-MTAB-2791 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse mammary tumors from animals which have exons 4-7 of the Lkb1 gene deleted
Heterozygous germ-line mutations in the LKB1 (STK11) gene cause Peutz-Jeghers syndrome (PJS), an autosomal dominant disorder characterized by hamartomatous polyposis of the gastrointestinal tract and an increased risk of colorectal, breast, ovarian, testicular and cervical cancer. To model the effec...
ORGANISM(S): Mus musculus 
2009-09-21 | E-TABM-643 | biostudies-arrayexpress
TranscriptomicsRNA-seq of mouse Lgr5+ intestinal stem cells and progenitors following Lkb1 deletion against controls
Perturbed intestinal epithelial homeostasis demonstrated as decreased Lgr5+ intestinal stem cells (Lgr5 ISCs) and increased secretory lineages were observed in our study where Lkb1 was specfically deleted in Lgr5 ISCs using Lgr5-EGFP-creERT2 (Tamoxifen) deletor. To gain mechanistic insight how Lkb1 ...
ORGANISM(S): Mus musculus 
2020-02-29 | E-MTAB-6501 | biostudies-arrayexpress
TranscriptomicsLoss of Lkb1 and Pten Leads to Lung Squamous Cell Carcinoma with Elevated Pdl1 Expression: Epithelial Cells
Lung squamous cell carcinoma (SCC) is a deadly disease for which current treatments are inadequate. We demonstrate that bi-allelic inactivation of Lkb1 and Pten in the mouse lung led to SCC that recapitulated the histology, gene expression and microenvironment found in human disease. Lkb1/Pten-null ...
ORGANISM(S): Mus musculus 
2014-01-24 | E-GEOD-54351 | biostudies-arrayexpress
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