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Long non-coding RNAs (lncRNAs) exert regulatory functions in a wide spectrum of biological contexts, and certain regulatory functions involve the formation of RNA-protein complexes. Discovering the structure/function of these complexes may unveil important functional insights. The DDX41 gene encodin...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-17 | PXD062695 | Pride
Long non-coding RNAs (lncRNAs) exert regulatory functions in a wide spectrum of biological contexts, and certain regulatory functions involve the formation of RNA-protein complexes. Discovering the structure/function of these complexes may unveil important functional insights. The DDX41 gene encodin...
ORGANISM(S): Mus musculus (Mouse) 
2025-01-13 | PXD055956 | Pride
We previously identified the stimuli-responsive lncRNA CALA to impact endothelial cell function and identified G3BP1 as a main interaction partner of CALA in the cytoplasm of human umblical vein endothelial cells (HUVECs). To uncover the role of the lncRNA CALA in G3BP1-RNPs in the cytoplasm, we pur...
ORGANISM(S): Homo sapiens (Human) 
2022-07-04 | PXD033517 | Pride
PCAT19 is an endothelial-enriched lncRNA that contributes to the proliferation-quiescence switch in a cell density-dependent manner. Here we performed an antisense-oligonucleotide pulldown of the PCAT19 lncRNA followed by mass spectrometry to identify protein interaction partners of PCAT19. Interact...
ORGANISM(S): Homo sapiens (Human) 
2022-09-29 | PXD032669 | Pride
Palmitic acid induced lncRNA PARAIL regulates inflammation via interaction with RNA-binding protein HuR in monocytes and macrophages
This project utilized CRISPR-assisted RNA-protein interaction detection (CARPID) combined with mass spectrometry to identify proteins interacting with the long non-coding RNA (lncRNA) TUG1 in HEK293T cells. TUG1 preferentially interacts with known R-loop-associated proteins, particularly under Campt...
ORGANISM(S): Homo Sapiens (human) 
The stimuli-responsive lncRNA CALA impacts endothelial cell function as silencing impairs angiogenic capacity in vitro. To uncover the molecular mechanism of CALA, we here combined antisense affinity selection of CALA-RNPs with mass spectrometry to identify the protein interactome of CALA. We theref...
ORGANISM(S): Homo sapiens (Human) 
2022-07-04 | PXD033516 | Pride
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