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TranscriptomicsTranscription profiling of sogenic Lrp(+) and Lrp(-) strains in cells growing in steady state in glucose minimal medium, either in the presence or absence of leucine. (Adaptation to famine)
Bacterial adaptation to nutrient limitation and increased population densities is central to survival and virulence. Surprisingly, <3% of Escherichia coli genes are known to play roles specific to the stationary phase. There is evidence that the leucine-responsive regulatory protein (Lrp) may play a...
ORGANISM(S): Escherichia coli 
2005-09-02 | E-SMDB-1726 | biostudies-arrayexpress
TranscriptomicsChIP-chip of E. coli K-12 MG1655 with antibody against ArgR-8myc, Lrp-8myc, and TrpR-8myc under various conditions.
We integrated transcription factor binding regions and mRNA transcript abundance to elucidate the ArgR, Lrp, and TrpR regulon experimentally. To measure transcription factor binding at a genome scale, we employed a ChIP-chip method to derivative strains of E. coli K-12 MG1655 harboring ArgR-8myc, L...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2011-12-01 | E-GEOD-26054 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of wild type, Lrp knock-out and LrpA1 knock-out Halobacterium salinarum
Changes of the transcriptional expression profile by Lrp and LrpA1 gene knock-outs
ORGANISM(S): Halobacterium salinarum 
2010-06-23 | E-MEXP-1447 | biostudies-arrayexpress
ProteomicsInfluence of LRP-1 on MDA-MB-231 secretome
LRP-1 (low-density lipoprotein receptor-related protein-1) receptor is a multifunctional endocytosis receptor that is part of the LDL receptor family. Due to its capacity to control the pericellular level of various growth factors and proteases, LRP-1 plays a crucial role in controlling the dynamics...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD022978 | Pride
Mda-mb-231 Breast cancer Lrp-1 
TranscriptomicsAdaptation to famine
Bacterial adaptation to nutrient limitation and increased population densities is central to survival and virulence. Surprisingly, <3% of Escherichia coli genes are known to play roles specific to the stationary phase. There is evidence that the leucine-responsive regulatory protein (Lrp) may play a...
ORGANISM(S): Escherichia coli 
2005-09-10 | E-GEOD-3283 | biostudies-arrayexpress
GenomicsHigh throughput analysis of binding of E. coli Lrp mutants
High throughput analysis of binding of E. coli Lrp mutants
PRJNA813682 | ENA
GenomicsHigh throughput analysis of binding of E. coli Lrp mutants
Feast-Famine Response Proteins are a widely conserved class of global regulators in prokaryotes, the most highly studied of which is the E. coli leucine-responsive regulatory protein (Lrp). Lrp senses environmental nutrition status and subsequently regulates up to one-third of the genes in E. coli, ...
ORGANISM(S): Escherichia coli 
2023-01-31 | GSE198120 | GEO
GenomicsEscherichia coli Lrp regulates one-third of the genome via direct, cooperative, and indirect paths
Escherichia coli Lrp regulates one-third of the genome via direct, cooperative, and indirect paths
PRJNA438455 | ENA
TranscriptomicsTranscription profiling of mouse decrement in Norrin/Frizzled4/Lrp signaling in retinal endothelial cells
To characterize the long-term effect on the transcriptome of a decrement in Norrin/Fz4/Lrp signaling, microarray hybridization was performed with RNA from acutely dissociated and anti-PECAM immunoaffinity-purified adult WT, Fz4-/-, Lrp5-/-, and Norrin- retinal vascular cells. Experiment Overall Desi...
ORGANISM(S): Mus musculus 
2009-10-10 | E-GEOD-16703 | biostudies-arrayexpress
GenomicsEscherichia coli Lrp regulates one-third of the genome via direct, cooperative, and indirect paths
The global regulator Lrp plays a crucial role in regulating metabolism, virulence and motility in response to environmental conditions.  Lrp has previously been shown to activate or repress approximately 10% of genes in Escherichia coli.  However, the full spectrum of targets, and how Lrp acts to re...
ORGANISM(S): Escherichia coli 
2018-11-28 | GSE111874 | GEO
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