Sort   by:  
 Page size 
ProteomicsWnt signalosome assembly is governed by conformational flexibility of Axin and AP2 clathrin adaptor
Wnt signal transduction relies on the direct inhibition of GSK3 by phosphorylated PPPSPxS motifs within the cytoplasmic tail of the LRP6 co-receptor. How GSK3 is recruited to LRP6 remains unclear. Here, we use nuclear magnetic resonance spectroscopy to identify the membrane-proximal PPPSPxS motif an...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2025-04-30 | PXD061649 | Pride
Gsk3 inhibition  lrp6 co-receptor  axin scaffold protein  ap2 cargo adaptor  clathrin-coated structures  wnt signalosome 
TranscriptomicsTranscriptional profiling of small intestinal crypts from mice treated with Notch blocking antibodies or Notch blocking antibodies in combination with an Lrp6 blocking antibody.
The goal of this study was to identify genes that are differentially expressed during a 24 hour Notch blockade and whether a Wnt antagonist (anti-Lrp6) could block this effect. 3 condition experiment, Control untreated compared to N1N2 treated, and N1N2 treated compared to N1N2_Lrp6 treated. 5 biolo...
ORGANISM(S): Mus musculus 
2015-03-11 | E-GEOD-66751 | biostudies-arrayexpress
UnknownRole of Wnt Co-Receptor LRP6 in Triple Negative Breast Cancer Cell Migration and Invasion.
Not available
S-EPMC10928515 | biostudies-literature
UnknownA Role for the WNT Co-Receptor LRP6 in Pathogenesis and Therapy of Epithelial Cancers.
Not available
S-EPMC6721565 | biostudies-literature
UnknownLoss-of-Function Mutations in the WNT Co-receptor LRP6 Cause Autosomal-Dominant Oligodontia.
Not available
S-EPMC4596913 | biostudies-literature
UnknownWnt signal amplification via activity, cooperativity, and regulation of multiple intracellular PPPSP motifs in the Wnt co-receptor LRP6.
Not available
S-EPMC2414294 | biostudies-literature
UnknownAssociation of a functional variant in the Wnt co-receptor LRP6 with early onset ileal Crohn's disease.
Not available
S-EPMC3285585 | biostudies-literature
UnknownAdiponectin inhibits Wnt co-receptor, Lrp6, phosphorylation and β-catenin signaling.
Not available
S-EPMC4747689 | biostudies-literature
UnknownOxidized phospholipids are ligands for LRP6.
Not available
S-EPMC6050227 | biostudies-literature
UnknownLRP6 downregulation promotes cardiomyocyte proliferation and heart regeneration.
Not available
S-EPMC8114926 | biostudies-literature
Sort   by:  
 Page size