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TranscriptomicsTranscription profiling of CD146 immunomagnetically enriched circulating endothelial cells (CECs) from healthy donors and patients with metastatic breast, colorectal, prostate, lung and renal cancer
Increased numbers of endothelial cells are observed in peripheral blood of cancer patients. These circulating endothelial cells (CECs) may contribute to the formation of blood vessels in the tumor or reflect vascular damage caused by treatment or tumor growth. Characterization of these cells may a...
ORGANISM(S): Homo sapiens 
2006-11-08 | E-MEXP-476 | biostudies-arrayexpress
ProteomicsProteomics-derived biomarker panel facilitates distinguishing primary lung adenocarcinomas with intestinal or mucinous differentiation (PAIM) from lung metastatic colorectal cancer (lmCRC)
The diagnosis of primary lung adenocarcinomas with intestinal or mucinous differentiation (PAIM) remains challenging due to the overlapping histomorphological, immunohistochemical and genetic characteristics with lung metastatic colorectal cancer (lmCRC). This study aimed to explore the protein biom...
ORGANISM(S): Homo sapiens (Human) 
2024-06-23 | PXD050416 | Pride
Primary lung adenocarcinomas  intestinal or mucinous differentiation  lung metastatic colorectal cancer  proteomics 
TranscriptomicsChromosomal copy number aberrations in colorectal metastases resemble their primary counterparts and differences are typically non-recurrent.
Background & Aims: The metastatic process is complex and remains a major obstacle in the management of colorectal cancer (CRC). To gain a better insight into the biologic events driving the metastatic process we investigated genomic aberrations in a large cohort of matched CRC primaries and distant ...
ORGANISM(S): Homo sapiens 
2014-02-10 | E-GEOD-38479 | biostudies-arrayexpress
ProteomicsSpatial Proteomic Analysis of Isogenic Metastatic Colorectal Cancer Cells Reveals Key Dysregulated Proteins Associated with Lymph Node, Liver and Lung Metastasis
Liver, lung and lymph nodes are the most common metatastic sites of colorectal cancer (CRC) cells. Here, we aimed to analyze by quantitative spatial proteomics the isogenic KM12 cell system (non-metastatic KM12C cells, liver metastatic KM12SM cells and liver and lung metastatic KM12L4a cells), and t...
ORGANISM(S): Homo sapiens (Human) 
2022-02-22 | PXD030671 | Pride
Spatial proteomics Colorectal cancer Tmt 11-plex Cells 
TranscriptomicsExpression profile of lung adenocarcinoma, A549 cells following targeted depletion of non metastatic 2 (NME2/NM23 H2)
Non-metastatic 2 (NME2) is an established metastases suppressor in multiple human cancer types. However, the molecular mechanisms of NME2 action remain insufficiently resolved. We recently validated the transcription regulatory activity of NME2 with respect to control of proto-oncogene c-MYC express...
ORGANISM(S): Homo sapiens 
2011-02-08 | E-GEOD-18182 | biostudies-arrayexpress
TranscriptomicsCNV analysis of human colorectal cancer (CRC) stem-like cells (CCSCs), stem-like circulating tumor cells (cCCSCs) and metastatic colorectal stem cells (mCCSCs).
Here we report that CCSCs themselves can sustain the maintenance of the primary human colorectal tumor and, through the activation of a functional EMT-program, drive the dissemination into the circulation and the colonization of distant organs.
ORGANISM(S): Homo sapiens 
2020-01-31 | E-MTAB-6942 | biostudies-arrayexpress
ProteomicsProteomic analysis of extracellular vesicles from inflammatory fibroblasts in colorectal cancer lung metastasis
Pulmonary metastasis is a major cause of mortality in colorectal cancer (CRC), and the tumor microenvironment plays a critical role in metastatic progression. In particular, inflammatory fibroblasts have been implicated in shaping the metastatic niche; however, the molecular characteristics of their...
ORGANISM(S): Homo Sapiens 
2026-03-20 | PXD075933 |
TranscriptomicsTranscription profiling of human colorectal cancer (CRC) stem-like cells (CCSCs), stem-like circulating tumor cells (cCCSCs) and metastatic colorectal stem cells (mCCSCs).
Here we report that CCSCs themselves can sustain the maintenance of the primary human colorectal tumor and, through the activation of a functional EMT-program, drive the dissemination into the circulation and the colonization of distant organs.
ORGANISM(S): Homo sapiens 
2020-01-31 | E-MTAB-6940 | biostudies-arrayexpress
GenomicsTargeted resequencing of human colorectal cancer (CRC) stem-like cells (CCSCs), stem-like circulating tumor cells (cCCSCs) and metastatic colorectal stem cells (mCCSCs).
Here we report that CCSCs themselves can sustain the maintenance of the primary human colorectal tumor and, through the activation of a functional EMT-program, drive the dissemination into the circulation and the colonization of distant organs.
ORGANISM(S): Homo sapiens 
2020-01-31 | E-MTAB-6944 | biostudies-arrayexpress
TranscriptomicsGene expression signature and the prediction of recurrence in stage III colorectal cancer by DNA microarray
Samples were taken from colorectal cancers in surgically resected specimens in 36 colorectal cancer patients. The expression profiles were determined using Affymetrix Human Genome U133 Plus 2.0 arrays. Comparison between the sample groups allow to identify a set of discriminating genes that can be u...
ORGANISM(S): Homo sapiens 
2010-08-31 | E-GEOD-4526 | biostudies-arrayexpress
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