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MetabolomicsA blood-based metabolic signature for earlier detection of lung cancer

Metabolomic profiling was applied to 1,259 sera collected within five years of a lung cancer diagnosis and 8,470 non-case sera from ever-smoker participants in the Prostate Lung Colorectal and Ovarian (PLCO) Study to identify metabolic signatures for the earlier detection of lung cancer. We devel...

2026-08-20 | MTBLS15406 | MetaboLights
Transcriptomicsp63+/Krt5+ Distal Airway Stem Cells are Essential for Lung Regeneration (transplanted and damaged)
The possibility of lung regeneration has been long discounted due to the irreversible nature of chronic lung diseases. However, patients who sustain massive loss of lung tissue during acute infections often recover full pulmonary function. Correspondingly, we previously demonstrated lung regenerat...
ORGANISM(S): Mus musculus 
2014-11-20 | E-GEOD-60830 | biostudies-arrayexpress
Transcriptomicsp63+/Krt5+ Distal Airway Stem Cells are Essential for Lung Regeneration (Dtox treatment)
The possibility of lung regeneration has been long discounted due to the irreversible nature of chronic lung diseases. However, patients who sustain massive loss of lung tissue during acute infections often recover full pulmonary function. Correspondingly, we previously demonstrated lung regenerat...
ORGANISM(S): Mus musculus 
2014-11-20 | E-GEOD-60829 | biostudies-arrayexpress
Transcriptomicsp63+/Krt5+ Distal Airway Stem Cells are Essential for Lung Regeneration (before and after in vitro differentiation)
The possibility of lung regeneration has been long discounted due to the irreversible nature of chronic lung diseases. However, patients who sustain massive loss of lung tissue during acute infections often recover full pulmonary function. Correspondingly, we previously demonstrated lung regenerat...
ORGANISM(S): Mus musculus 
2014-11-20 | E-GEOD-60828 | biostudies-arrayexpress
Transcriptomicsp63+/Krt5+ Distal Airway Stem Cells are Essential for Lung Regeneration (tracheal epithelium and alveoli)
The possibility of lung regeneration has been long discounted due to the irreversible nature of chronic lung diseases. However, patients who sustain massive loss of lung tissue during acute infections often recover full pulmonary function. Correspondingly, we previously demonstrated lung regenerat...
ORGANISM(S): Mus musculus 
2014-11-20 | E-GEOD-61091 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of pulmonary alveoli from calorie-restricted mice at different timepoints to study the molecular mechanism of alveoli loss.
Pulmonary alveoli are complex architectural units thought to undergo endogenous or pharmacologically induced programs of regeneration and degeneration. To study the molecular mechanism of alveoli loss mice were calorie restricted at different timepoints. Lungs were harvested and processed for RNA ex...
ORGANISM(S): Mus musculus 
2007-11-06 | E-GEOD-478 | biostudies-arrayexpress
Transcriptomicsp63+/Krt5+ Distal Airway Stem Cells are Essential for Lung Regeneration
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-11-20 | E-GEOD-60849 | biostudies-arrayexpress
TranscriptomicsAge-dependent decline in lung regeneration with loss of clonogenicity and myofibroblastic differentiation of lung fibroblasts
While aging leads to a reduction in the capacity for regeneration after pneumonectomy (PNX) in most mammals, this biological phenomenon has not been characterized over the lifetime of mice. We measured the age-specific (3, 9, 24 month) effects of PNX on physiology, morphometry, cell proliferation an...
ORGANISM(S): Mus musculus 
2011-03-16 | E-GEOD-27964 | biostudies-arrayexpress
TranscriptomicsGenomic differences distinguish the myofibroblast phenotype of distal lung from airway fibroblasts
ABSTRACT Primary human distal lung/parenchymal fibroblasts (DLF) exhibit a different phenotype from airway fibroblasts (AF), including the expression of high levels of a-smooth muscle actin (a-SMA). The scope of the differences and the mechanisms driving them are unknown. To determine whether disti...
ORGANISM(S): Homo sapiens 
2011-07-21 | E-GEOD-27335 | biostudies-arrayexpress
TranscriptomicsFunctional Roles of Hdac1/2 in lung development
Hdac1/2 are important epigenetic factors, yet their functional roles in specific tissues inluding lung is not determined. We used the conditional knockout model of Hdac1/2 to determine their roles in lung development. To explore the genes that are regulated by Hdac1/2 during lung development, we per...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-39946 | biostudies-arrayexpress
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