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TranscriptomicsLysophosphatidic acid receptor expression identifies a pure population of adult hippocampal stem cells with an immune cell-related transcriptional profile
Lysophosphatidic acid receptor 1 (LPA1) is a phospholipid which has been linked to adult hippocampal neurogenesis and learning deficits. Here we investigated whether LPA acts directly on the hippocampal stem cells and whether LPA1 could be a functional marker for their prospective isolation. Our res...
ORGANISM(S): Mus musculus 
2016-07-03 | E-GEOD-68270 | biostudies-arrayexpress
TranscriptomicsAutotaxin and its product lysophosphatidic acid suppress brown adipose differentiation and promote diet-induced obesity in mice
Brown adipose tissue (BAT) is a thermogenic organ that dissipates stored energy as heat to maintain body temperature in infants and small mammals. This process may also provide protection from development of diet-induced obesity. We found that the bioactive lipid mediator lysophosphatidic acid (LP...
ORGANISM(S): Mus musculus 
2011-06-01 | E-GEOD-26442 | biostudies-arrayexpress
ProteomicsIdentification of phosphorylation sites regulated by lysophosphatidic acid (LPA) in OCMI91s ovarian cancer cells
Elevated levels of lysophosphatidic acid (LPA) species accumulate in the ascites of ovarian high grade serous cancer (HGSC) and are associated with a short relapse-free survival. LPA is known to support the metastatic spread of cancer cells by activating a multitude of signaling pathways through G-p...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-01-25 | MSV000091146 | MassIVE
ProteomicsIdentification of phosphorylation sites regulated by lysophosphatidic acid (LPA) in OVCAR8 ovarian cancer cells
Elevated levels of lysophosphatidic acid (LPA) species accumulate in the ascites of ovarian high grade serous cancer (HGSC) and are associated with a short relapse-free survival. LPA is known to support the metastatic spread of cancer cells by activating a multitude of signaling pathways through G-p...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-01-26 | MSV000091158 | MassIVE
ProteomicsHepatic AKAP1 Deficiency Exacerbates Diet-Induced MASLD by Enhancing GPAT1-mediated Lysophosphatidic Acid Synthesis
Metabolic dysfunction-associated steatotic liver disease (MASLD), closely associated with obesity, can progress to metabolic dysfunction-associated steatohepatitis when the liver undergoes overt inflammatory damage. A-kinase anchoring protein 1 (AKAP1) has been shown to control lipid accumulation in...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-26 | PXD062388 | Pride
Akap1  masld  lysophosphatidic acid  gpat1  triglyceride synthesis. 
TranscriptomicsTranscriptomic analysis of human breast and prostate cancer cell lines on lysophosphatidic acid (LPA) stimulation
LPA is a natural bioactive lipid with growth factor-like functions due to activation of series of six G protein-coupled receptors (LPA1-6). In this study we determine the LPA induced early-gene expression profile in three unrelated human cancer cell lines (MDA-MB-231, MCF7, PC3) with an objective to...
ORGANISM(S): Homo sapiens 
2014-05-16 | E-GEOD-56265 | biostudies-arrayexpress
TranscriptomicsMonocyte derived macrophages treated with lysophosphatidic acid
Peripheral blood monocytes were differentiated into macrophages, starved for 24h hours, and treated for 3h with LPA 18:0, 20:4 or a mix of LPAs similar to the composition in ascites (1 µM 16:0 + 0.25 µm 18:0 + 0.5 µM 18:1 + 1.625 µM 18:2 + 1.625 µM 20:4). RNA expression was measured via QuantSeq.
ORGANISM(S): Homo sapiens 
2024-12-31 | E-MTAB-13993 | biostudies-arrayexpress
TranscriptomicsSpleen vs Lysophosphatidic Acid Treated B cell
total RNA from mouse (male c57BL/6) spleen labeled with Cy3 vs total RNA from mouse (male c57BL/6) B cells treated with Lysophosphatidic Acid labeled with Cy5- time course with repeats Keywords: ordered
ORGANISM(S): Mus musculus 
2003-04-14 | GSE388 | GEO
GenomicsTumor-derived Lysophosphatidic Acid Blunts Protective Type-I Interferon Responses in Ovarian Cancer
Tumor-derived Lysophosphatidic Acid Blunts Protective Type-I Interferon Responses in Ovarian Cancer
PRJNA754392 | ENA
Unknown2-Carba-lysophosphatidic acid is a novel β-lysophosphatidic acid analogue with high potential for lysophosphatidic acid receptor activation and autotaxin inhibition.
Not available
S-EPMC8405639 | biostudies-literature
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