lysosomal acidification

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Astaburuaga2019 - ODE model of lysosomal ion homeostasis (LIH) including calcium pathways

To investigate the putative differential effect of chloride transport on lysosomal ion homeostasis,we generated an ODE mathematical model for this system. Our mathematical model builds upon a previously published model for lysosomal homeostasis (Grabe et al. 2001 J. Gen. Physiol, Ishida et al. 2013 ...

2019-10-22 | MODEL1910220001 | BioModels

Ubiquilin interactomes from Fly

Mutations in Ubiquilins, UBQLN2, and UBQLN4 cause familial ALS. The role of UBQLNs in proteasomal degradation is well established but their role in autophagy-lysosomal clearance is poorly defined. Here, we performed Ubqn-GFP pull down from fly samples to find Ubqn binding partners.

ORGANISM(S): Drosophila <fruit Fly, Genus> (ncbitaxon:7215)

2018-12-18 | MSV000083259 | MassIVE

Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo.

Not available

S-EPMC6917501 | biostudies-literature

Quantitative Phosphoproteomic Analyses Identify STK11IP as a Lysosome-Specific Substrate of mTORC1 that Regulates Lysosomal Acidification

The evolutionarily conserved serine/threonine kinase mTORC1 is a central regulator of cell growth and proliferation. mTORC1 is activated on the lysosome surface. However, once mTORC1 is activated, it is unclear whether mTORC1 phosphorylates local lysosomal proteins to regulate specific aspects of ly...

ORGANISM(S): Homo sapiens (Human)

2022-05-20 | PXD031543 | Pride

Phosphoproteomics stk11ip

Misrouting of v-ATPase subunit V0a1 dysregulates lysosomal acidification in a neurodegenerative lysosomal storage disease model.

Not available

S-EPMC5344305 | biostudies-literature

RORα Enhances Lysosomal Acidification and Autophagic Flux in the Hepatocytes.

Not available

S-EPMC8631090 | biostudies-literature

Mitochondria-lysosome coupling contributes to lysosome acidification and aging

Nearly all cellular processes are pH dependent. The acidic pH inside the lysosome (vacuole in yeast) is essential for cellular content degradation, signaling, and autophagy. Defect in lysosome/vacuole acidification is a conserved hallmark of aging and age-related diseases. Traditionally, lysosome/va...

ORGANISM(S): Homo sapiens

2026-03-20 | GSE292573 | GEO

Mitochondrial translation deficiency impairs NAD⁺ -mediated lysosomal acidification.

Not available

S-EPMC8047443 | biostudies-literature

Soluble adenylyl cyclase is essential for proper lysosomal acidification.

Not available

S-EPMC5037342 | biostudies-literature

The Effect of Cellular Coenzyme Q10 Deficiency on Lysosomal Acidification.

Not available

S-EPMC7355799 | biostudies-literature