mechanism of actions

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1Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA 2Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA 5Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA 8Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA (1)
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Deciphering mechanism of actions of novel compounds by bioactive thermal proteome profiling

Exploring the therapeutic effects of bioactive compounds has been traditionally approaching by phenotypic screenings followed by functional validation by in vitro assays. The thermal proteome profiling (TPP) has been successfully applied to study drug targets and off-target. We applied a modified pr...

ORGANISM(S): Homo sapiens (Human)

2019-06-28 | PXD013227 | Pride

Mechanism and cellular actions of the potent AMPK inhibitor BAY-3827

PRJNA1225752 | ENA

Computational mechanism underlying switching of motor actions.

Not available

S-EPMC11875378 | biostudies-literature

Transcription profiling of rat pooled untreated cultured ovaries vs. pooled cultured ovaries treated with anti-Mullerian hormone

The oocytes found within the primordial follicles of mammalian ovaries remain quiescent for months to years until they receive the appropriate signals to undergo the primordial to primary follicle transition and initiate folliculogenesis. The molecular mechanisms and extracellular signaling factors ...

ORGANISM(S): Rattus norvegicus

2008-04-07 | E-GEOD-10557 | biostudies-arrayexpress

Mechanism for differential recruitment of orbitostriatal transmission during actions and outcomes following chronic alcohol exposure.

Not available

S-EPMC8016477 | biostudies-literature

Adaptive actions as a mechanism of change in transdiagnostic internet-delivered cognitive behavioral therapy: Comparison with homework engagement.

Not available

S-EPMC12720989 | biostudies-literature

Do good actions inspire good actions in others?

Not available

S-EPMC4264010 | biostudies-literature

Presynaptic mechanism for anti-analgesic and anti-hyperalgesic actions of kappa-opioid receptors.

Not available

S-EPMC6740440 | biostudies-literature

Transcription profiling of human activated T lymphocytes to determine the effects of TX527, a hypocalcemic vitamin D analog

Hypocalcemic vitamin D analogs are appealing molecules to exploit the immunomodulatory actions of active vitamin D in vivo. The functional modulation of dendritic cells is regarded as the key mechanism underlying their ability to regulate T cell responses. In contrast, the direct actions of vitamin ...

ORGANISM(S): Homo sapiens

2010-11-15 | E-GEOD-23984 | biostudies-arrayexpress

Stable peptide-assembled nanozyme mimicking dual antifungal actions.

Not available

S-EPMC11224359 | biostudies-literature

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