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MetabolomicsThe putative ceramide-conjugation protein Cwh43 regulates G0 quiescence, nutrient metabolism and lipid homeostasis in fission yeast (Metabolome assay)
Cellular nutrient states control whether cells proliferate, or whether they enter or exit quiescence. Here, we report characterizations of fission yeast temperature-sensitive (ts) mutants of the evolutionarily conserved transmembrane protein, Cwh43, and explore its relevance to utilization of glucos...
2018-08-17 | MTBLS577 | MetaboLights
MetabolomicsThe putative ceramide-conjugation protein Cwh43 regulates G0 quiescence, nutrient metabolism and lipid homeostasis in fission yeast (Lipidome assay)
Cellular nutrient states control whether cells proliferate, or whether they enter or exit quiescence. Here, we report characterizations of fission yeast temperature-sensitive (ts) mutants of the evolutionarily conserved transmembrane protein, Cwh43, and explore its relevance to utilization of glucos...
2018-08-21 | MTBLS578 | MetaboLights
ProteomicsVAP-mediated membrane tethering mechanisms implicate ER-PM contact function in pH homeostasis
MS analyses of interactome of full-length (i.e., Scs2 and Scs22) and TM-truncated (i.e., Scs2N and Scs22N) fission yeast VAPs.
ORGANISM(S): Schizosaccharomyces Pombe (fission Yeast) 
2024-08-09 | PXD053887 | JPOST Repository
TranscriptomicsHairpin RNA induces secondary small interfering RNA synthesis and silencing in trans in fission yeast
We provide evidence of the generation of Rdp1-mediated secondary siRNAs in vivo in fission yeast. Secondly, we show that the presence of Ago1-associated siRNAs does not guarantee robust silencing. We obtained sequences from gel purified small RNAs of wt and rdp1delta fission yeast cells and FLAG-ago...
ORGANISM(S): Schizosaccharomyces pombe 
2010-02-15 | E-GEOD-20330 | biostudies-arrayexpress
GenomicsMediator promotes CENP-A incorporation at fission yeast centromeres
This SuperSeries is composed of the following subset Series: GSE32310: Transcriptome analysis of mediator Med20 mutant and dcr1 mutant in S.pombe GSE35524: Mediator promotes CENP-A incorporation at fission yeast centromeres [ChIP-seq] Refer to individual Series
ORGANISM(S): Schizosaccharomyces pombe 
2012-11-06 | E-GEOD-35527 | biostudies-arrayexpress
TranscriptomicsCell-cycle regulation of cohesin stability along fission yeast chromosomes
Sister chromatid cohesion is mediated by cohesin but the process of cohesion establishment during S phase is still enigmatic. Recent data indicate that in mammalian cells, cohesin binding to chromatin is dynamic in G1 but becomes stabilized during S phase. Whether the regulation of chromosomal cohes...
ORGANISM(S): Schizosaccharomyces pombe 
2007-11-30 | E-GEOD-8450 | biostudies-arrayexpress
GenomicsMediator promotes CENP-A incorporation at fission yeast centromeres [ChIP-seq]
At Schizosaccharomyces pombe centromeres, heterochromatin formation is required for de novo incorporation of the histone H3 variant CENP-A/Cnp1, which in turn directs kinetochore assembly and ultimately chromosome segregation during mitosis. Noncoding RNAs (ncRNAs) transcribed by RNA polymerase II (...
ORGANISM(S): Schizosaccharomyces pombe 
2012-11-06 | E-GEOD-35524 | biostudies-arrayexpress
TranscriptomicsThe unfolded protein response in fission yeast modulates stability of select mRNAs to maintain protein homeostasis
Homeostatic control mechanisms are essentil to life. One such mechanism, the unfolded protein response (UPR) operates in all eukarytic cells to adjust protein folding capacity of the endoplasmic reticulum (ER) according to need. UPR induction in all eurkarytic cells to date involves Ire1 (kinase/end...
ORGANISM(S): Schizosaccharomyces pombe 
2012-11-21 | E-GEOD-40298 | biostudies-arrayexpress
TranscriptomicsTranscriptional profile of an eca39∆ mutant fission yeast
An branched-chain amino acids auxotroph eca39∆ mutant fission yeast exhibits an unusual adaptive growth phenotype on solid minimal media containing Ile, Leu and Val when other strains are growing nearby. The transcriptional profiles of an eca39∆ mutant before and after the adaptation were determined...
ORGANISM(S): Schizosaccharomyces pombe 
2012-09-21 | E-GEOD-29355 | biostudies-arrayexpress
ProteomicsA conserved membrane curvature-generating protein is crucial for autophagosome formation in fission yeast
Organelles are shaped by curvature-generating proteins, which include the reticulons and REEPs that are involved in forming the endoplasmic reticulum (ER). A conserved REEP subfamily differs from the ER-shaping REEPs in abundance and membrane topology and has unidentified functions. Here, we show th...
ORGANISM(S): Schizosaccharomyces pombe 927 
2023-08-06 | PXD043260 | Pride
Reep1 Autophagy Fission yeast 
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