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TranscriptomicsGenome-wide identification of Ago2 binding sites from mouse embryonic stem cells with and without mature microRNAs
MicroRNAs (miRNAs) are a large family of 19-22nt non-coding RNAs that post-transcriptionally regulate their mRNA targets. Computational algorithms predict that over half of all genes are regulated by miRNAs, yet approaches for experimental identification of miRNA binding sites are now emerging. To ...
ORGANISM(S): Mus musculus 
2011-01-10 | E-GEOD-25310 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling by array of Klf2 wild-type and Klf2-Null mESCs cultured under 2i
The self-renewing pluripotent state was first captured in mouse embryonic stem cells (mESCs) over two decades ago. The standard condition requires the presence of serum and LIF, which provide growth promoting signals for cell expansion. However, there are pro-differentiation signals which destabiliz...
ORGANISM(S): Mus musculus 
2014-06-04 | E-MTAB-2366 | biostudies-arrayexpress
GenomicsMus musculus strain:mESCs 129/SVEV
Dispensed mESCs gene expression
PRJDB9392 | ENA
ProteomicsFLAG-BMAL1 Immunoprecipitation followed by LC MS/MS in mESCs
Immunoprecipitation with anti-FLAG antibody in nuclear extracts of FLAG-BMAL1 expressing mESCs. LC MS/MS was used to analyze the interactome of BMAL1 in mESCs.
ORGANISM(S): Mus musculus (Mouse) 
2025-08-16 | PXD050769 | Pride
Bmal1  mescs 
TranscriptomicsQuantitative Analysis of Wild Type(wt) and Setd2 knockout(ko) mESCs Transcriptomes [RNA-Seq]
Purpose: This study aimed at exploring the deregulated genes in setd2 knockout mESCs compared with wt, more particularly to find the mechanism controlled by setd2,which was required for endoderm differentiation. Methods: Setd2 wt and ko mESCs were generated by deep sequencing, using Illumina GAIIx. ...
ORGANISM(S): Mus musculus 
2014-10-14 | E-GEOD-54932 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression pattern between Wild-type and Setd2 knockout mESCs [Affymetrix]
SETD2/HYPB has been known as a histone H3K36 specific methyltransferase. However, its roles in physiology such as development and cellular function remain unclear. In this study, using mESCs as cellular model, we show that Setd2 mainly regulates differentiation of murine embryonic stem cells (mESCs)...
ORGANISM(S): Mus musculus 
2014-10-14 | E-GEOD-54931 | biostudies-arrayexpress
GenomicsAcute depletion of Tet1-dependent 5-hydroxymethylcytosine levels impairs LIF/Stat3 signaling and results in loss of embryonic stem cell identity [MRE-seq]
The TET family of FE(II) and 2-oxoglutarate-dependent enzymes (Tet1/2/3) promote DNA demethylation by converting 5-methylcytosine to 5-hydroxymethylcytosine (5hmC), which they further oxidize into 5-formylcytosine and 5-carboxylcytosine. Tet1 is robustly expressed in mouse embryonic stem cells (mESC...
ORGANISM(S): Mus musculus 
2012-01-06 | E-GEOD-34887 | biostudies-arrayexpress
GenomicsGenome-wide characterization of menin-dependent H3K4me3 reveals a specific role for menin in the regulation of genes implicated in MEN1-like tumors (ChIP-Seq)
Inactivating mutations in the MEN1 gene predisposing to the multiple endocrine neoplasia type 1 (MEN1) syndrome can also cause sporadic pancreatic endocrine tumors. MEN1 encodes menin, a subunit of MLL1/MLL2-containing histone methyltransferase complexes that trimethylate histone H3 at lysine 4 (H3K...
ORGANISM(S): Mus musculus 
2012-06-01 | E-GEOD-37774 | biostudies-arrayexpress
GenomicsTranscriptome of Ago1_KO mESCs
Transcriptome of Ago1_KO mESCs
PRJNA741499 | ENA
TranscriptomicsIdentifying PD0325901-regulated genes in the J1 mESCs
It has been demonstrated that PD0325901 promotes self-renewal of mouse embryonic stem cells, however, the target genes of PD0325901 are not fully understood. To better understand the downstream target genes of PD0325901, we performed Microarray analyses to identify their downstream targets. The data...
ORGANISM(S): Mus musculus 
2016-05-17 | E-GEOD-67534 | biostudies-arrayexpress
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